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Bioinformatics: A Modern Approach

Bioinformatics: A Modern Approach


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About the Book

Being an interdisciplinary subject, Bioinformatics is today covering a range of interest both among the students and teaching communities. Taking this increasing interest into account, this book gives a comprehensive introduction to the subject. The text not only deals with the basic concepts but it also emphasizes the technical and practical aspects of the subject. The book covers the computational tools in bioinformatics, algorithmic aspects as well as technological aspects. Besides it gives a clear exposition of Viterbi algorithm, Hidden Markov models, UPGMA, FM algorithm, heuristic, developing and using substitution matrices, HMMs and derivation of a number of standard formulae in information theory and statistics. Finally the text focuses on the technological aspects of bioinformatics such as sequencing through shot gun methods, microarrays, with a variety of unsupervised methods in data analysis with examples, as well as interdisciplinary research in systems biology. The book is primarily intended as a text for the students of Computer Science, Information Technology, undergraduate students of Bioinformatics, PGDCA and biological sciences and biotechnology. The book should also be of considerable interest for research scientist in Chemistry and Pharmacy.

Table of Contents:
List of Figures. List of Tables. Preface. Acknowledgements. Prologue. Introduction. Part I: Introduction to Bioinformatics -; 1. Getting Started with Linux. Part II: Programming, Database Management and Information Theory -; 2. World Wide Web.; 3. Perl and Java.; 4. Information Theory. Part III: Sequence Databases and Sequence Analysis -; 5. National Center for Biotechnology Information (NCBI).; 6. Blast and Fasta: A Search for Similarity. Part IV: Multiple Sequence Alignment, Phylogenetic Analysis and Gene Prediction -; 7. Pairwise Sequence Alignment and Dynamic Programming.; 8. Phylogeny.; 9. Gene Prediction. Part V: Protein Databases, Protein Domain Searching, and Structure Prediction -; 10. Protein Data Bank (PDB).; 11. Domain Assignment and Searching.; 12. Native Structure Prediction and Protein Folding Prediction. Part VI: Sequencing & Genome Mapping -; 13. Genome Sequencing.; 14. Maps. Part VII: Microarrays & Systems Biology -; 15. Why the Buzz About Microarrays?; 16. Microarray Design, Data Acquisition and Analysis.; 17. Proteomics.; 18. Systems Biology - The Holy Grail of Integration.; 19. Public Domain Databases and Analysis Tools: A Compendium. Model Questions. Appendix: Fundamentals of Probability. Epilogue. Bibliography. Index.

About the Author :
VITTAL R. SRINIVAS (M.S., M.Engg., Rensselaer Polytechnic Institute, New York, USA), was a Project Officer in the Department of Biotechnology, Indian Institute of Technology Madras. He completed dual masters level education from Rensselaer Polytechnic Institute, New York, USA and has done training in biological applications on problems related to medicine mainly using computational approaches. Currently he is pursuing research towards his doctoral degree at Rice University, Houston, Texas. An interdisciplinary scientist, with varied background that range, from engineering to cell biology and bioinformatics. Mr. Vittal Srinivas prefers to be called an engineer-biologist. He is interested in solving problems that impinges on molecular medicine and etiology of diseases using a multidisciplinary approach.


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Product Details
  • ISBN-13: 9788120328587
  • Publisher: PHI Learning
  • Publisher Imprint: Prentice-Hall of India Pvt.Ltd
  • Height: 235 mm
  • No of Pages: 280
  • Width: 178 mm
  • ISBN-10: 8120328582
  • Publisher Date: 01 Dec 2005
  • Binding: Paperback
  • Language: English
  • Sub Title: A Modern Approach


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