Bioinformatics for Geneticists
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Bioinformatics for Geneticists

Bioinformatics for Geneticists


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About the Book

This timely book illustrates the value of bioinformatics, not simply as a set of tools but rather as a science increasingly essential to navigate and manage the host of information generated by genomics and the availability of completely sequenced genomes. Bioinformatics can be used at all stages of genetics research: to improve study design, to assist in candidate gene identification, to aid data interpretation and management and to shed light on the molecular pathology of disease-causing mutations. Written specifically for geneticists, this book explains the relevance of bioinformatics showing how it may be used to enhance genetic data mining and markedly improve genetic analysis.

Table of Contents:
List of Contributors. Foreword. SECTION I: AN INTRODUCTION TO BIOINFORMATICS FOR THE GENETICIST. Introduction: The Role of Genetic Bioinformatics (Michael R. Barnes and Ian C. Gray). Internet Resources for the Geneticist (Michael R. Barnes and Christopher Southan). Human Genetic Variation: Databases and Concepts (Michael R. Barnes). Finding, Delineating and Analysing Genes (Christopher Southan). SECTION II: THE IMPACT OF COMPLETE GENOME SEQUENCES ON GENETICS. Assembling a View of the Human Genome (Colin A. Semple). Mouse and Rat Genome Informatics (Judith A. Blake, Janan Eppig and Carol J. Bult). Genetic and Physical Map Resources -- An Integrated View (Michael R. Barnes). SECTION III: BIOINFORMATICS FOR GENETIC STUDY DESIGN. From Linkage Peak to Culprit Gene: Following Up Linkage Analysis of Complex Phenotypes with Population--based Association Studies (Ian C. Gray). Genetic Studies from Genomic Sequence (Michael R. Barnes). SNP Discovery and PCR--based Assay Design: From In Silico Data to the Laboratory Experiment (Ellen Vieux, Gabor Marth and Pui Kwok). Tools for Statistical Analysis of Genetic Data (Aruna Bansal, Peter R. Boyd and Ralph McGinnis). SECTION IV: BIOLOGICAL SEQUENCE ANALYSIS AND CHARACTERIZATION. Predictive Functional Analysis of Polymorphisms: An Overview (Michael R. Barnes). Functional In Silico Analysis of Non--coding SNPs (Thomas Werner). Amino Acid Properties and Consequences of Substitutions (Matthew J. Betts and Robert B. Russell). SECTION V: GENETICS/GENOMICS INTERFACES. Gene Expression Informatics and Analysis (Antoine H. C. van Kampen, Jan M. Ruijter, Barbera D. C. van Schaik, Huib N. Caron and Rogier Versteeg). Proteomic Informatics (Jerome Wojcik and Alexandre Hamburger). Concluding Remarks: Final Thoughts and Future Trends (Michael R. Barnes and Ian C. Gray). Appendix I. Appendix II. Glossary. Index.

Review :
"...a very valuable and important resource for bringing bioinformatics into the work practice of geneticists." (Clinical Chemistry, December 2004) "..valuable in this newly emerging discipline called 'Bioinformatics'." (Journal of Statistical Computation & Simulation, September 2004) "Although this book is aimed primarily at professional geneticists, the numerous worked examples would be useful to anyone putting a course together on this topic." (Biochemistry and Molecular Education, May/ June 2004) "...This book is essential reading for all those engaged in genetic research and should prove indispensable ..." (CAB Abstracts) "...a useful addition to the library of a seasoned scientist...a useful resource in itself, cataloguing the 'how' and 'why' ..." (Briefings in Bioinformatics, June 2004) "...a very valuable and important resource for bringing bioinformatics into the work practice of geneticists...we strongly recommend this book..." (Clinical Chemistry, 2004)


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Product Details
  • ISBN-13: 9780470843949
  • Publisher: John Wiley and Sons Ltd
  • Publisher Imprint: John Wiley & Sons Ltd
  • Height: 229 mm
  • Returnable: N
  • Width: 152 mm
  • ISBN-10: 0470843942
  • Publisher Date: 21 Feb 2003
  • Binding: Paperback
  • Language: English
  • Weight: 622 gr


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