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Najnowsze postępy w bioanalitycznych metodach wykrywania biomarkerów

Najnowsze postępy w bioanalitycznych metodach wykrywania biomarkerów


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Zakażenia schistosomami mają poważne konsekwencje dla rozwoju spoleczno-gospodarczego wielu krajów tropikalnych. Te wyniszczające i przewlekle choroby występują endemicznie w ponad 70 krajach, ale narzędzia diagnostyczne są ograniczone i konieczne są nowe testy, aby ograniczyc zachorowalnośc i śmiertelnośc. Opracowanie takich testów może zostac ulatwione dzięki identyfikacji biomarkerów specyficznych dla danej choroby, które są dodatnie we wczesnej fazie zakażenia, pozwalają odróżnic zakażenie ostre od przewleklego i mogą slużyc do potwierdzenia wyleczenia. Niniejsza praca ma dwa glówne cele: (a) identyfikację wzorców proteomicznych specyficznych dla poszczególnych stadiów wczesnego (3 tygodnie), ostrego (6 tygodni) i przewleklego (12 tygodni) zakażenia Schistosoma mansoni w modelu mysim; (b) profilowanie surowicy osób zakażonych S. mansoni lub S. haematobium i porównanie tych wzorców z profilem bialkowym surowicy zdrowych osób. Aby osiągnąc te cele, przeprowadzono analizy proteomiczne surowicy myszy i ludzi przy użyciu kilku różnych metod spektrometrii masowej (MS).


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Product Details
  • ISBN-13: 9786200749178
  • Publisher: Wydawnictwo Nasza Wiedza
  • Publisher Imprint: Wydawnictwo Nasza Wiedza
  • Height: 229 mm
  • No of Pages: 92
  • Returnable: N
  • Weight: 186 gr
  • ISBN-10: 6200749175
  • Publisher Date: 23 Jul 2025
  • Binding: Paperback
  • Language: Polish
  • Returnable: N
  • Spine Width: 6 mm
  • Width: 152 mm


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