Infrared and Raman Spectroscopic Imaging

A comparison of the strengths and weaknesses of near-infrared, infrared and Raman imaging, focusing on current as well as conceivable applications for chemical analysis in delicate natural and synthetic samples. This handbook and ready reference covers instrumentation for vibrational spectroscopic imaging, chemometric evaluation of spectroscopic images, and vibrational spectroscopic imaging in biology and medicine, as well as the chemical, pharmaceutical and food industries.

Table of Contents:
PART I: Basic Methodology INFRARED AND RAMAN INSTRUMENTATION FOR MAPPING AND IMAGING Introduction to Mapping and Imaging Mid-Infrared Microspectroscopy and Mapping Raman Microspectroscopy and Mapping Near-Infrared Hyperspectral Imaging Raman Hyperspectral Imaging Mid-Infrared Hyperspectral Imaging Mapping with Pulsed Terahertz Radiation CHEMOMETRIC TOOLS FOR IMAGE ANALYSIS Introduction Hyperspectral Images: The Measurement Image Preprocessing Exploratory Image Analysis Quantitative Image Information : Multivariat Image Regression (MIR) Image Segmentation Image Resolution PART II: Biomedical Applications VIBRATIONAL SPECTROSCOPIC IMAGING OF SOFT TISSUE Introduction Preparation of Soft Tissue for Vibrational Spectroscopic Imaging Applications to Soft Tissues VIBRATIONAL SPECTROSCOPIC IMAGING OF HARD TISSUE Infrared and Raman Spectroscopy of Bone Infrared and Raman Imaging of Bone Infrared and Raman Spectroscopy of Cartilage Infrared and Raman Imaging of Cartilage INFRARED AND RAMAN SPECTROSCOPY AND SPECTRAL IMAGING OF INDIVIDUAL CELLS Introduction Methods Results and Discussion 3-D IMAGING OF BIOMEDICAL SAMPLES Introduction Methodologies Resultant 3-D Images PART III: Agricultural Applications FT-IR MICROSPECTROSCOPIC IMAGING OF PLANT MATERIAL Introduction, Background and Perspective Application of IMS to Kernels and Seeds of Plants Leaves Application of IMS to Stems and Cellulose Polymers Algae NEAR-INFRARED HYPERSPECTRAL IMAGING IN FOOD AND AGRICULTURAL SCIENCE Introduction At the Laboratory Scale At the Industrial Scale PART IV: Polymers and Pharmaceuticals FT-IR AND NIR SPECTROSCOPIC IMAGING: PRINCIPLES, PRACTICAL ASPECTS AND APPLICATIONS IN MATERIAL AND PHARMACEUTICAL SCIENCES Introduction Instrumentation for FT-IR and NIR Imaging Applications of FT-IR Imaging for Polymer Research and Quality Control NIR Imaging Spectroscopy for Quality Control of Pharmaceutical Drug Formulations ATR-FT-IR IMAGING FOR PHARMACEUTICAL AND POLYMERIC MATERIALS: FROM MICRO TO MACRO APPROACHES Introduction The Versatility of ATR-FT-IR Imaging Applications of ATR-FT-IR Imaging in the Materials Sciences Applications of ATR-FT-IR Imaging in the Pharmaceutical Sciences ATR-FT-IR Imaging for Forensic Applications RAMAN SPECTRAL IMAGING ON PHARMACEUTICAL PRODUCTS Overview Hyperspectral Imaging Empirical Approach to Successful Raman Hyperspectral Imaging Raman in Multimodal Hyperspectral Imaging PART V: Developments in Methodology DEEP, NONINVASIVE RAMAN SPECTROSCOPY OF DIFFUSELY SCATTERING MEDIA Introduction Techniques for Deep, Noninvasive Raman Spectroscopy Examples of Application Areas Outlook on Raman Tomography PLANAR ARRAY INFRARED SPECTROSCOPY AND 1-D IMAGING Introduction Concept and Instrumentation PA-IR Spectroscopy Applications BIOMEDICAL APPLICATIONS OF INFRARED MICROSPECTROSCOPY USING SYNCHROTRON RADIATION Introduction Spatial Resolution Considerations Advantages of a Synchrotron IR Source Instrumentation Biological Sample Preparation and Modes of Data Collection Biological and Medical Applications on Synchrotron IR Microspectroscopy Future Directions for Synchrotron IR Microspectroscopy SPECTROSCOPIC IMAGING WITH NANOMETER RESOLUTION USING NEAR-FIELD METHODS Introduction Methods Applications Current Challenges

About the Author :
Reiner Salzer retired as Professor of Analytical Chemistry at the Technische Universität Dresden, Germany. He obtained his academic degrees from the University of Leipzig, before taking up his appointment at the TU Dresden. He has authored over 250 books and scientific publications and was elected onto various national and international boards. Professor Salzer is a member of the Norwegian Academy of Science and, a recipient of the Emich Plaque of the Austrian Society of Analytical Chemistry. He is a long-time advisory board member for analytical and spectroscopic journals. Professor Salzer served as President of the Division Analytical Chemistry of the German Chemical Society and is National Delegate to the Division Analytical Chemistry of EuCheMS, where he is Head of the Study Group Education. He was elected as a member of the ECTNA Label Committee for the Chemistry Eurobachelor and Chemistry Euromaster. Heinz W. Siesler has been a professor of Physical Chemistry at the University of Duisburg-Essen, Germany, since 1987. After receiving his PhD in chemistry in 1970 from the University of Vienna, Austria, he worked as a post-doc at the University of Cologne, Germany, and at the Witwatersrand University, Johannesburg, South Africa. Prior to his present position he gained industrial experience as section head in molecular spectroscopy and thermal analysis in the Corporate R&D Department of Bayer AG, Germany. Between 1992 and 2008 he held guest professorships in France, Japan, and Austria. Professor Siesler is a recipient of the EAS Award, the Tomas Hirschfeld Award and the Buechi Award in near-infrared spectroscopy. His main research focuses on the application of vibrational spectroscopy to chemical and polymer research, analysis and quality control, and he has written over 190 publications in this field.

Review :
"The book provides a full overview of the potential of vibrational spectroscopy in biology, food, and pharmaceutical fields. The instrumentation, data processing, applications, and recent developments are presented. The book is clearly written in a comprehensive manner. It represents a valuable resource for everyone working in IR and/or Raman microimaging." (Anal Bioanal Chem, 2010) "An especially positive aspect of the book is the strong emphasis on practical relevance in the chapters. ... Recommended both to method developers and to applications practitioners in academic and industrial laboratories." (Angewandte Chemie International Edition, February 2010)