Amiloride and Analogs
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Book 1
Book 2
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Book 1
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Book 1
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Home > Medicine & Health Science textbooks > Medical specialties, branches of medicine > Pharmacology > Amiloride and Analogs: Unique Cation Transport Inhibitors
Amiloride and Analogs: Unique Cation Transport Inhibitors

Amiloride and Analogs: Unique Cation Transport Inhibitors


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About the Book

The rapidly growing interest in cation transport phenomena has captured the attention of chemists, biologists and medical scientists. Amiloride and certain of its analogs possess unique Na+-channel, Na+/H+-antiport, Na+/Ca2+-exchange and/or voltage-dependent Ca2+-channel inhibitory activity. This book reviews the extensive literature on the subject, puts the concepts in perspective, reveals the applications, and regards the future of cation regulating agents in biological sciences and medicine.

Table of Contents:
Part 1 Introduction: historical perspective; an overview of the structure-activity relationships in the amiloride series; the synthesis of amiloride and its analogues. Part 2 Transport systems affected by amiloride analogues: amiloride-sensitive sodium channels; Na+/H+ exchange in epithelia; Na+/H+ exchange in blood cells; Na+/H+ exchange in an excitable tissue; Na+/Ca+ exchange; voltage-dependent Ca2+ channels; inhibition of sodium-dependent solute cotransport in renal brush border membrane vesicles by amiloride; cellular systems - enzymes, receptors, and metabolic pathways. Part 3 Biological applications and immunological approaches: radiolabelled analogues; photoreactive amiloride analogues; generation, characterization, and utilization of anti-amiloride antibodies; generation of antibiodies directed against the amiloride binding site on specific transport proteins by an anti-idiotypic approach. Part 4 Molecular biology: molecular organization of the human amiloride-sensitive Na+/H+ antiporter gene; molecular biology of the Na+/H+ exchanger amiloride binding site. Part 5 Clinical applications: K+ sparing diuretics; antihypertensive agents; amiloride in cystic fibrosis - safety, pharmacokinetics, and efficacy in the treatment of pulmonary disease; the use of Na+/H+ antiporter inhibitors as a novel approach to cancer treatment; other pontential medical uses and summary.


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Product Details
  • ISBN-13: 9783527281466
  • Publisher: Wiley-VCH Verlag GmbH
  • Publisher Imprint: Wiley-VCH Verlag GmbH
  • Height: 235 mm
  • Width: 155 mm
  • ISBN-10: 3527281460
  • Publisher Date: 21 Dec 1992
  • Binding: Hardback
  • Sub Title: Unique Cation Transport Inhibitors


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