Amiloride and Its Analogs
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Amiloride and Its Analogs: Unique Cation Transport Inhibitors

Amiloride and Its Analogs: Unique Cation Transport Inhibitors


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About the Book

The rapidly growing interest in cation transport phenomena has captured the attention of chemists, biologists and medical scientists. Amiloride and certain of its analogs possess unique Na+-channel, Na+/H+-antiport, Na+/Ca2+-exchange and/or voltage-dependent Ca+-channel inhibitory activity. This book reviews the extensive literature on the subject, puts the concepts in perspective, reveals the applications, and regards the future of cation regulating agents in biological sciences and medicine.

Table of Contents:
Contributors; Section A Introduction; 1. Historical Perspective; Edward J. Cragoe, Jr.; 2. An Overview of the Structure - Activity Relations in the Amiloride Series; Louis Simchowitz, Thomas R. Kleyman, and Edward J. Cragoe, Jr.; 3. The Synthesis of Amiloride and Its Analogs; Edward J. Cragoe, Jr.; Section B Transport Systems Affected by Amiloride Analogs; 4. Amiloride--Sensitive Sodium Channels; Young S. Oh and Dale J. Benos; 5. Na + /H + Exchange in Epithelia; Robert F. Reilly and Peter S. Aronson; 6. Na + /H + Exchange in Blood Cells; William E. Dale and Louis Simchowitz; 7. Na + /H + Exchange in an Excitable Tissue; Peter J. Little; 8. Na + /Ca 2+ Exchange; Gregory J. Kaczorowski; 9. Voltage--Dependent Ca 2+ Channels; Gregory J. Kaczorowski and Maria L. Garcia; 10. Inhibition of Sodium--Dependent Solute Cotransport in Renal Brush Border Membrane Vesicles by Amiloride; Julian L. Seifter, Robert A. Lufburrow III, and Raymond C. Harris; 11. Cellular Systems: Enzymes, Receptors, and Metabolic Pathways; Jeffrey M. Besterman; Section C Biologic Applications and Immunologic Approaches; 12. Radiolabeled Analogs; Paul Vigne and Christian Frelin; 13. Photoreactive Amiloride Analogs; Chaomei Lin and Thomas R. Kleyman; 14. Generation, Characterization, and Utilization of Anti--Amiloride Antibodies; Thomas R. Kleyman; 15. Generation of Antibodies Directed Against the Amiloride--Binding Site on Specific Transport Proteins by an Antiidiotypic Approach; Brigitte Coupaye--Gerard and Thomas R. Kleyman; Section D Molecular Biology; 16. Molecular Organization of the Human Amiloride--Sensitive Na + /H + Antiporter Gene; Gilles Pages, Claude Sardet, and Jacques Pouyssegur; 17. Molecular Biology of the Na + /H + Exchanger Amiloride--Binding Site; Laurent Counillon, Claude Sardet, and Jacques Pouyssegur; Section E Clinical Applications; 18. K + Sparing Diuretics; George M. Feldman and Krystyna Drewnowska; 19. Antihypertensive Agents; Francis J. Haddy and Motilal B. Pamnani; 20. Amiloride in Cystic Fibrosis: Safety, Pharmacokinetics, and Efficacy in the Treatment of Pulmonary Disease; Michael R. Knowles, Nina L. Church, William E. Waltner, John T. Gatzy, and Richard C. Boucher; 21. The Use of Na + /H + Antiporter Inhibitors as a Novel Approach to Cancer Treatment; Salvador Harguindey; 22. Other Potential Medical Uses and Summary; Edward J. Cragoe, Jr.; Index


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Product Details
  • ISBN-13: 9780471187943
  • Publisher: John Wiley and Sons Ltd
  • Publisher Imprint: John Wiley & Sons Inc
  • Height: 241 mm
  • Returnable: N
  • Sub Title: Unique Cation Transport Inhibitors
  • Width: 162 mm
  • ISBN-10: 0471187941
  • Publisher Date: 07 Dec 1992
  • Binding: Hardback
  • Language: English
  • Spine Width: 26 mm
  • Weight: 728 gr


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