Zero – Much to Do About Nothing?

Zero – Much to Do About Nothing? is a thought-provoking work that delves into the complexities of defining “zero” in various fields, from mathematics and physics to pharmacology and food safety. Drawing on his extensive experience in teaching, research and managing a USDA-supported chemical food safety program, Jim E. Riviere provides readers with practical examples and case studies that highlight the challenges of defining “zero” in different contexts across a wide range of fields. In his four decades of university teaching, doing research in pharmacology, toxicology, biomathematics and nanoscience, Dr. Riviere has repeatedly encountered the concept of “zero” and the broad parameters utilized to achieve a proper definition. "Zero” enters when discussions concern defining "nothing", "negligible", "very small", "below level of detection", "absence of effect" or "safe". This renders the term “zero” incredibly confusing to scientists, practitioners and regulators.   This book explores the origin of the concept of “zero” in mathematics, physics, chemistry and statistics and how these concepts migrated to fields such as pharmacology, toxicology, cancer research and food safety, as well as to the legal profession in the form of regulatory science and policy. Specific chapters deal with the application of “zero” to these distinct fields. The main focus throughout the book is to illustrate how important context is to the definition of “zero”. This has assumed greater relevance today with the advent of nanoscience where “small” implies different physical and chemical behavior and the use of artificial Intelligence to analyze vast troves of data from the web. The goal of the book is to provide much-needed clarity about "zero" and break down the many issues preventing it. Riviere expertly explains how the concept of “zero” is essential to a wide range of issues, from defining negligible amounts of a substance to determining the safety of a product or process. He shows how the term “zero” can have different meanings in different fields and how this can lead to confusion and misunderstandings among scientists, practitioners and regulators. Whether you're working in Food Safety, Chemistry, Pharmacology, Mathematics, Physics or beyond, Zero – Much to Do About Nothing? is a relatable book that will deepen your understanding of the concept of “zero” and its diverse applications.

Table of Contents:
Introduction and Overview.- Philosophy.- History of Zero as a Number.- Zero in Mathematics and Statistics.- Physics.- Chemistry and Limits of Analytical Detection and Quantitation.- Biology and Pharmacology.- Toxicology Dose Makes the Difference.- Cancer.- Food Safety.- Doping and Performance Drugs, Substances of Abuse, Death, Finance and Other Encounters with Zero.- Summary and Personal Conclusions.

About the Author :
Jim E. Riviere is a Distinguished Professor Emeritus at North Carolina State University and Kansas State University in Raleigh, NC