About the Book
With the start of 2020, the wrath of pandemic challenged the scientific community to develop more advanced drug delivery approaches for biomedical applications, endowing conventional drugs with additional therapeutic benefits and minimum side effects. Although significant advancements have been done in the field of drug delivery, there is a need to focus towards strategizing novel and improved drug delivery systems that should be convenient and cost-effective to the patients, and simultaneously they should also provide financial benefits to pharmaceutical companies. Controlled drug delivery technology offers ample opportunities and scope for improvising the therapeutic efficacy of drugs via optimizing thedrug release rate and time. For this endeavour, smart nanomaterials have served as remarkable candidates for biomedical applications, owing to their ground-breaking properties and design. The development of such nanomaterials requires a broad knowledge related to their physio-chemical properties, molecular structure, mechanisms by which the nanomaterials interact with the cells, and methods by which drugs are released at the site of action. This knowledge must also be allied with the knowledge of signaling crosstalk mechanisms that are modulated by the nanomaterial-drugs composite. It can be anticipated that these emerging drug delivery technologies can facilitate the world to successfully encounter such pandemic outbursts in the future in a cost-effective and time-effective manner. The chapters in this book deal with the advanced technologies and approaches that can benefit advanced students, researchers, and industry experts in developing smart and intelligent nanomaterials for future biomedical applications, and development, manufacturing, and commercialization for controlled and targeted drug delivery.
Table of Contents:
Foreword.- Preface.- Introduction to active smart nanomaterials for biomedical applications.- Cancer cell sensing and therapy using affinity tag-conjugated gold nanoparticles.- Gold nanoparticles enlighten the future of cancer theranostics.- Recent advances in hydrogels smart drug delivery systems.- Carbon-based nanomaterials for biomedical applications.- A new era of cancer treatment: carbon nanotubes as drug delivery tools.- pH- and ion-sensitive materials for control drug delivery.- Thermo-responsive polymers and their application as smart biomaterias.- Redox-responsive polymers and their application in drug delivery systems.- Recent strategies to explore the biomedical applications of nanocellulose.- Tissue engineering using cellulose nanofibrils as Scaffold material.- Use of solidlipid nanoparticles to improve the oral bioavailability of poor soluble drugs.- Applications of dendrimers in drug delivery systems.- Liposomes for drug delivery: progress and problems.- Cubosome nanoparticles for enhanced delivery of anticancer drug.- Layer-by-Layer assemblies for cancer diagnosis and treatment.- Polymeric micelles for drug delivery.- Role of plant-based materials/gums in developing drug delivery systems.- Ethosomes: A novel tool for drug delivery through the skin.- Niosomes as nanoparticular drug carriers: fundamentals and recent applications.- Graphene oxide nanosheets used in photothermal therapy.- Metal doped carbon dots used in bio-imaging and cancer therapy.- Bibliography.- Glossary.- Index.
About the Author :
Professor Jin-Chul Kim is currently working as a Professor at Department of Biomedical Science & Institute of Bioscience and Biotechnology, Kangwon National University, South Korea, since 2003. Earlier he worked as a senior researcher at LG Household & healthcare, Republic of Korea (1999 – 2003). He completed his Post-doctoral research at Department of Industrial and Physical Pharmacy (IPPH), Purdue University, USA (1997 – 1998). He received his Master’s and Doctorate degree from Department of Chemical Engineering, Korea Advanced Institute of Science and Technology (KAIST), Republic of Korea (1991 – 1997) and his Bachelor’s degree from Department of Chemical Engineering, Yonsei University, Republic of Korea (1987-1991). He has more than 25 years of experience in teaching and research in both academia and industry. He has published more than 300 scientific papers in SCI/SCIE-grade journals as a lead author/corresponding author. He has many awards to his credit, to name a few, Outstanding Teacher Award (Kangwon National University, 2014), Teaching Award (Kangwon National University, 2008), Outstanding Researcher Award (LG household & healthcare, 2001), Patent Award (LG household & healthcare, 2001), Patent Award (LG Chem., 2000), and Award in championship Transport Phenomenon Competition for University Student (Korean Chemical Engineering Society, 1990). He was the leader of a team, named “Education and research team for cultivation of graduate students talented with development of drug carriers for biopharmaceuticals delivery”, under BK21 PLUS (2016-2020). He is leading a research part “Development of biomedical materials based on nanocellulose” of the Priority Research Centers Program of the National Research Foundation of Korea (NRF) funded by the Ministry of Education (2018-2027). He is the leader of a team, named “Education and research team for cultivation of graduate students globally and convergently talented with development of drug carriers for biopharmaceuticals delivery”, under BK21 FOUR (2020-2027). His current research interests include drug delivery systems, colloid & interfaces science, and polymer science.
Dr. Madhusudhan Alle is currently working as a Research Professor at Department of Biomedical Science & Institute of Bioscience and Biotechnology, Kangwon National University, South Korea (since 2018). Earlier he has worked as an Associate Professor at Department of Chemistry, Gondar University, Gondar, Ethiopia (2014-2018). During this period he also served as a Coordinator of MSc (Chemistry) Programs and as the Head of the Chemistry Department. Four students submitted their master’s thesis under his supervision. He received his doctorate from Department of Chemistry, Osmania University, India (2013), where he worked on the research projects sponsored by University Grants Commission, India. He has more than 18 years of experience in teaching and research in both academia and industry. He has published more than 50 scientific papers in SCI/SCIE-grade journals as a first and corresponding author and also published 4 book chapters (Springer and Elsevier). He is also listed as a potential reviewer for many reputed international journals. He is also a member of Ethiopian chemical society and Indian chemical society. He has presented his work in several national and international conferences in India, Ethiopia, and South Korea. He has conducted two research projects sponsored by University Grants Commission (UGC), New Delhi, India. His current research interests include biosciences, polymeric nano-drug delivery systems, cancer biology, biomaterials for sustainability and catalysis. Extraction and chemical modification of nanocellulose from lignocellulosic biomass, green synthesis of metal and metal oxide nanoparticles on nanocellulose support and their novel applications in biomedicine, biosensors and catalysis.
Professor Azamal Husen (BSc from Shri Murli Manohar Town Post Graduate College, Ballia, UP, MSc from Hamdard University, New Delhi, and PhD from Forest Research Institute, Dehra Dun, India) is a Foreign Delegate at Wolaita Sodo University, Wolaita, Ethiopia. He has served the University of Gondar, Ethiopia, as a Full Professor of Biology, and also worked as the Coordinator of the MSc Program and as the Head, Department of Biology. He was a Visiting Faculty of the Forest Research Institute, and the Doon College of Agriculture and Forest at Dehra Dun, India. He has more than 20 years’ experience of teaching, research, and administration. Dr Husen specializes in biogenic nanomaterial fabrication and their application, plant responses to nanomaterials, plant production and adaptation to harsh environments at the physiological, biochemical, and molecular levels, herbal medicine, and clonal propagation and improvement of tree species. He has conducted several research projects sponsored by various funding agencies, including the World Bank, the Indian Council of Agriculture Research (ICAR), the Indian Council of Forest Research Education (ICFRE); and the Japan Bank for International Cooperation (JBIC). He has published over 100 research papers, review articles and book chapters, edited books of international repute, presented papers in several conferences, and produced over a dozen manuals and monographs. Dr Husen received four fellowships from India and a recognition award from the University of Gondar, Ethiopia, for excellent teaching, research, and community service. An active organizer of seminars/conferences and an efficient evaluator of research projects and book proposals, Dr Husen has been on the Editorial board and the panel of reviewers of several reputed journals published by Elsevier, Frontiers Media SA, Taylor & Francis, Springer Nature, RSC, Oxford University Press, Sciendo, The Royal Society, CSIRO, PLOS, and John Wiley & Sons. He is on the advisory board of Cambridge Scholars Publishing, UK. He is a Fellow of the Plantae group of the American Society of Plant Biologists, and a Member of the International Society of Root Research, Asian Council of Science Editors, ISDS, and INPST. In addition, he is Editor-in-Chief of the American Journal of Plant Physiology; and a Series Editor of ‘Exploring Medicinal Plants’, published by Taylor & Francis Group, USA.
