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Home > Mathematics and Science Textbooks > Biology, life sciences > Biochemistry > Protein Targeting and Translocation: (12 Research Monograph)
Protein Targeting and Translocation: (12 Research Monograph)

Protein Targeting and Translocation: (12 Research Monograph)


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About the Book

Within a eukaryotic organism up to 95 per cent weight for weight of the cell's membranes are used in the formation of intracellular structures such as the nucleus, endoplasmic reticulum ER, golgi, mitochondria, chloroplasts and microbodies, (peroxisomes/glyoxisomes). To allow each membrane bound compartment to carry out its role there is considerable protein traffic between proteins and they must be able to pass across these semi-permeable barriers and in the case of membrane proteins insert into the bilayer. Furthermore the cell must have a means of maintaining proteins at their final functional location against the bulk flow of protein for example in the ER and golgi. The mechanism by which large proteins are able to undergo subcellular targeting and then cross a hydrophobic bilayer has been one that has puzzled scientists for a number of years and a question that has been investigated by a wide range of techniques from biophysics to molecular biology. By bringing together experts in the field this book aims to go some way ahead to answering these questions.

Table of Contents:
Part 1 Membrane interaction: biophysics of the membrane interface and its involvement in protein targeting and translocation; amphiphilic-helices and lipid interactions; signal sequences - initiators of protein translocation; determinants of membrane protein topology and membrane anchoring; insertion of single- and multi-spanning proteins into the bacterial cytoplasmic membrane. Part 2 Prokaryotic protein targetting and translocation: prokaryotic protein translocation; protein traffic from the cytosol to the outer membrane of "Escherichia coli"; "sec"-dependent prokaryotic protein secretion; targeting and assembly of fimbriae. Part 3 Eukaryotic protein targeting and translocation: targeting to and translocation across the endoplasmic reticulum membrane; protein localization to the endoplasmic reticulum and golgi complex; import and export of proteins at the nucleus; mitochondrial targeting and import; translocation of proteins into and across the thylakoid membrane; principles of peroxismal protein sorting and assembly; targeting of glyoxysomal proteins.


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Product Details
  • ISBN-13: 9781855781214
  • Publisher: PORTLAND PRESS
  • Publisher Imprint: Portland Press
  • Height: 230 mm
  • ISBN-10: 1855781212
  • Publisher Date: /08/1998
  • Binding: Hardback
  • Series Title: 12 Research Monograph


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