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Handbook for Chemical Process Research and Development

Handbook for Chemical Process Research and Development


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About the Book

The Handbook for Chemical Process Research and Development focuses on developing processes for chemical and pharmaceutical industries. Forty years ago there were few process research and development activities in the pharmaceutical industry, partially due to the simplicity of the drug molecules. However, with the increasing structural complexity, especially the introduction of chiral centers into the drug molecules and strict regulations set by the EMA and FDA, process R&D has become one of the critical departments for pharmaceutical companies. This book assists with the key responsibility of process chemists to develop chemical processes for manufacturing pharmaceutical intermediates and final drug substances for clinical studies and commercial production.

Table of Contents:
Chapter 1: Modes Of Reagent Addition – Control of Impurity Formation Chapter 2: Process Optimization Chapter 3: Hazardous Reactions Chapter 4: Catalytic Reactions Chapter 5: Grignard Reagent And Related Reactions Chapter 6: Challenging Reaction Intermediates Chapter 7: Protecting Groups Chapter 8: Reaction Solvents Chapter 9: Base Reagent Selection Chapter 10: Reagents For Amide Formation Chapter 11: Various Reagent Surrogates Chapter 12: Telescope Approach Chapter 13: Stereochemistry Chapter 14: Design Of New Synthetic Route Chapter 15: Reaction Workup Chapter 16: Pharmaceutical Salts Chapter 17: Solid Form

About the Author :
Dr. Wenyi Zhao, Senior Research Scientist (Process Chemistry), Member of the American Chemical Society. 1980–1990: Ph.D., Organic/Physical Organic Chemistry, Nanjing University, China. 1990–1992: Postdoctoral fellow at the Institute of Chemistry, Chinese Academy of Sciences, Beijing. 1992–1995: Associate Professor at the Institute of Photographic Chemistry, Chinese Academy of Sciences, Beijing (now the Institute of Chemistry, Chinese Academy of Sciences, Beijing). 1995–2001: Senior Research Associate in the Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, Texas. Early in 2001, Dr. Zhao moved into the private sector to become a process chemist in the pharmaceutical industry in the United States. He is the author of numerous journal articles and holds several patents.


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Product Details
  • ISBN-13: 9781498768009
  • Publisher: Taylor & Francis Ltd
  • Publisher Imprint: CRC Press
  • Language: English
  • ISBN-10: 1498768008
  • Publisher Date: 03 Nov 2016
  • Binding: Digital (delivered electronically)


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