This fully updated second edition reflects the significant changes in process chemistry since the first edition and includes more common process issues such as safety, cost, robustness, and environmental impact. Some areas have made notable progress such as process safety, stereochemistry, new reagents and reagent surrogates. Forty years ago there were few process research and development activities in the pharmaceutical industry, partly due to the simplicity of drug molecules. With increasing structural complexity especially the introduction of chiral centers into drug molecules and stricter regulations, process R&D has become one of the critical departments for pharmaceutical companies.
Features:
This unique volume now in its second edition is designed to provide readers with an unprecedented strategy and approach which will help chemists and graduate students develop chemical processes in an efficient manner. Promotes an industrial mindset concerning safety and commercial viability when developing methods. The author discusses development strategies with case studies and experimental procedures. Focuses on mechanism-guided process development which provides readers with practical strategies and approaches. Addresses more common process issues such as safety, cost, robustness, and environmental impact.This book provides a new direction for scientists, researchers, and students in materials science and polymer chemistry who seek to better understand the chemistry behind conducting polymers and improve their performance for use in advanced energy applications.
Table of Contents:
1. Reaction solvent selection
2. Reagent selection
3. Various reagent surrogates
4. Modes of reagent addition -control of impurity formation
5. Process optimization with additives
6. Process optimization of catalytic reactions
7. Process optimization of problematic reactions
8. Hazards of oxidation and reduction reactions
9. Other hazardous reactions
10. Hazardous reagents
11. Grignard reagent and related reactions
12. Challenging reaction intermediates
13. Protecting groups
14. Telescope approach
15. Design of new synthetic route
16. Stereochemistry
17. Various quenching strategies
18. Various isolation and purification strategies
19. Methods for residual metal removal
20. Methods for impurity removal
21. Pharmaceutical salts
22. Solid form
About the Author :
Dr Wenyi Zhao, Senior Research Scientist (Process Chemistry), Member of American Chemical Society. 1980-1990: Ph.D., Organic/Physical Organic Chemistry, Nanjing University, China. 1990-1992: Postdoctoral fellow in Institute of Chemistry, Chinese Academy of Sciences, Beijing. 1992-1995: Associate professor in Institute of Photographic Chemistry, Chinese Academy of Sciences, Beijing (Now becomes Institute of Chemistry, Chinese Academy of Sciences, Beijing). 1995-2001: Sr. research associate in Department of Chemistry, Texas Tech University, Lubbock, Texas 2001 - 2005. Dr Wenyi Zhao then moved into the private sector to become a process chemist in the pharmaceutical industry in the US with over 15 years of experience. He is the author of numerous journal articles and holds several patents.
