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High-Throughput Analysis in the Pharmaceutical Industry

High-Throughput Analysis in the Pharmaceutical Industry


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About the Book

The introduction of combinatorial chemistry technology has increased the amount of compounds generated in a year from 50 to 2000. Conventional analytical approaches simply cannot keep up. These circumstances have caused drug discovery to take on the shape of a bottleneck, like traffic through a toll booth. In order to break the bottleneck, a corres

Table of Contents:
High-Throughput Sample Preparation Techniques and Their Application to Bioanalytical Protocols and Purification of Combinatorial Libraries. On-line Sample Extraction Coupled with Muliplexing Strategy to Improve Throughput. Optimizing LC/MS Equipment to Increase Throughput in Pharmaceutical Analysis. Throughput Improvement of Bioanalytical LC/MS/MS by Sharing Detector between HPLC Systems. High-Throughput Strategies for Metabolite Identification in Drug Discovery. Utilizing Microparallel Liquid Chromatography for High-Throughput Analyses in the Pharmaceutical Industry. Strategies and Techniques for Higher Throughput ADME/PK Assays. High-Throughput Analysis in Drug Metabolism During Early Drug Discovery. High-Throughput Analysis in Support of Process Chemistry and Formulation Research and Development in the Pharmaceutical Industry. Online Solid Phase Extraction LC/MS/MS for High-Throughput Bioanalytical Analysis. Applications of High-Throughput Analysis in Therapeutic Drug Monitoring. High-Throughput Quantitative Pharmaceutical Analysis in Drug Metabolism and Pharmacokinetics Using Liquid Chromatography-Mass Spectrometry. Designing High-Throughput HPLC Assays for Small and Biological Molecules. Advances in Capillary and Nano HPLC Technology for Drug Discovery and Development. High-Throughput Analysis of Complex Protein Mixtures by Mass Spectrometry. Index

Review :
This book, edited by Perry G. Wang, provides excellent up-to-date reviews on the newest developments of high-throughput analysis in drug discovery and development ... has a good balance of both theoretical and practical information that should appeal to a broad base of readers ... remains as a quick and valuable resource for the readers, ranging from professionals to academics, to gain knowledge about the most recent developments of high-throughput analysis in the pharmaceutical industry. -- Keyang Xu, Genentech, Inc., 2009 ! an appropriate and timely contribution to the scientific literature. ! offers valuable details and insights into each research area. ! very helpful to both newcomers to the field, as well as industry veterans. --Dr. James N. Kyranos, FORMA Therapeutics (US), in ChemMedChem 2009, vol. 4


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Product Details
  • ISBN-13: 9781420059540
  • Publisher: Taylor & Francis Inc
  • Publisher Imprint: CRC Press Inc
  • Language: English
  • ISBN-10: 1420059548
  • Publisher Date: 20 Aug 2008
  • Binding: Digital (delivered electronically)


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