Anticancer Drug Toxicity
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Anticancer Drug Toxicity: Prevention, Management, and Clinical Pharmacokinetics

Anticancer Drug Toxicity: Prevention, Management, and Clinical Pharmacokinetics


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About the Book

Containing the latest findings on the toxicity of a wide range of chemotherapeutic agents, this up-to-the-minute reference offers expert analyses on the pharmacokinetic-pharmacodynamic and pharmacokinetic-toxicodynamic relationships of anticancer compounds. Anticancer Drug Toxicity explores therapeutic drug monitoring (TDM) as a method of maximizing the efficacy, and minimizing the dangers, of chemotherapy presents a vast amount of clinical pharmacokinetic data on cytostatic drugs offers a comprehensive classification of toxicity patterns associated with the use of cytotoxic drugs analyzes the pharmacokinetics of alkylating agents, platinum compounds, anthracyclines, antimetabolites, semisynthetic podophyllotoxin- and camptothecin derivatives, mitotic inhibitors, and other cytotoxic agents highlights the pharmacogenetics of 6-mercaptopurine and its clinical significance explicates toxicity in relation to the lungs, kidneys, heart, and gonads examines disorders caused by asparaginase preparations reviews types of secondary malignancy such as leukemias, ovarian cancer, testicular cancer, breast cancer, secondary solid neoplasias, and Hodgkin's disease clarifies the understanding of toxicity as a crucial element in supportive management of cancer therapy and more! An enormously practical guide for everyday clinical practice, as well as a source of inspiration for further research in the field, Anticancer Drug Toxicity is an invaluable reference for clinical and medical oncologists; hospital, industrial, and clinical pharmacologists and pharmacists; toxicologists; pharmaceutical chemists; radiologists; and graduate and medical school students in these disciplines.

Table of Contents:
Introduction and Clinical Pharmacokinetics Introduction, Hans-Peter Lipp Clinical Pharmacokinetics of Cytostatic Drugs: Efficacy and Toxicity, Hans-Peter Lipp and Carsten Bokemeyer Toxicity of Cytostatics in Rapidly Proliferating Normal Cells Prophylaxis and Treatment of Neutropenia with Hematopoietic Growth Factors, Hartmut Link Oral and Gastrointestinal Toxicity, Carsten Bokemeyer and J. T. Hartmann Dermatological Toxicity and Hypersensitivity Reactions Associated with the Use of Cytostatics, Hans-Peter Lipp Extravasation and Paravasation Managing Extravasations of Vesicant Chemotherapy Drugs, Robert T. Dorr Organ Toxicity Induced by Cytostatic Agents Nephrotoxicity and Urotoxicity of Chemotherapeutic Agents, Roderick Skinner Hepatotoxicity Induced by Cytostatic Drugs, Hans-Peter Lipp, Joachim Boos, Eugen J. Verspohl, Eugene Y. Krynetski, and William E. Evans Neurotoxicity (Including Sensory Toxicity) Induced by Cytostatics, Hans-Peter Lipp Pulmonary Toxicity of Chemotherapeutic Agents, Jost Niedermeyer, H. Fabel, Carsten Bokemeyer, and Hans-Peter Lipp Cardiotoxicity of Cytostatic Drugs, Hans-Peter Lipp Late Side-Effects of Cancer Chemotherapy Gonadal Toxicity and Teratogenicity After Cytotoxic Chemotherapy, Elizabeth B. Lamont and Robert L. Schilsky Secondary Malignancies, Carsten Bokemeyer and Christian Kollmannsberger


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Product Details
  • ISBN-13: 9781420001730
  • Publisher: Taylor & Francis Inc
  • Publisher Imprint: Taylor & Francis Inc
  • Language: English
  • No of Pages: 576
  • Returnable: N
  • ISBN-10: 1420001736
  • Publisher Date: 13 Apr 1999
  • Binding: Digital (delivered electronically)
  • No of Pages: 576
  • Returnable: N
  • Sub Title: Prevention, Management, and Clinical Pharmacokinetics


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