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Anticancer Drugs

Anticancer Drugs


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About the Book

This book presents the lectures, questions to and answers of, some of the main leaders in the field of cancer pharmacology and cancer chemotherapy participating in the First International Interface of Clinical and Laboratory Responses to Anti-Cancer Drugs, which took place on March 13, 14, and 15, 1989 in Villejuif. The questions which were asked, concerned mechanisms of cell death or resistance, the significance of tumor cell heterogeneity for drug effects, and how information on determinants of drug action can be utilized to design selective drugs for chemotherapy.

Table of Contents:
Part 1 New drugs, new mechanisms: screening of oncogene function inhibitors, possible antitumor agents; mitochondria as a reservoir for anticarcinoma drugs; relationship of chemical charge of anti-cancer agents to increased accumulation and cytotoxity in cardiac and tumor cells; relevance to multi-drug resistance; new anthracycline analogues directed against DNA topoisomerase II; bifunctional intercalators, a new class of antitumor drugs able to induce futile DNA repair; clinical aspect of drug modulation and potentiation; DNA as target for anticancer drug action; role of reactive oxygen metabolites in the cytotoxicity of anticancer quinones; pathways of resistance to topoisomerase II inhibitors; the involvement of glutathione S-transferases in drug resistance; mechanism of target cell lysis by cytotoxic cells, factor and drugs; immunomodulation by anticancer agents - adriamycin and tumor necrosis factor; induction of tumor cell differentiation as a common mechanism of action of DNA-specific antitumor agents; induced cytodifferentiation of transformed cells; an approach to cancer treatment; correlation between oncostatic, differentiating, immunologic and virostatic agents and actions - 1 experimental immunologic and virostatic agents and actions - 2 clinical study. Part 2 Resistance and circumvention: probing modes of multi-drug resistance via photodynamic effects of anthrapyrazoles; drug transport in multi-drug resistant tumor cells; a revision of the pump-hypothesis; pharmacological and molecular characterizsation of three rodent cell lines in culture selected for resistance to doxorubicin; chemotherapeutic targets for the modulation of multi-drug resistance; heterogeneous forms of P-glycoprotein in multi-drug resistant J774.2 cells; P-glycoprotein as a target for chemosensitizing agents; signal transduction mechanisms in multi-drug resistance; are all human cancers chemocurable?; characteristics of clinical and experimental resistance to cisplatine; antifolate resistance; in vitro versus in vivo.


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Product Details
  • ISBN-13: 9780861962235
  • Publisher: John Libbey & Co
  • Publisher Imprint: John Libbey & Co Ltd
  • Height: 240 mm
  • ISBN-10: 0861962230
  • Publisher Date: 01 Jan 1989
  • Binding: Paperback
  • Width: 170 mm


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