About the Book
This timely volume brings together the latest basic and clinical insights on the cellular and mediator mechanisms involved in the induction and persistence of airway dysfunction of asthma by over 90 experts in the field-paving the way for developing novel and more effective antiinflammatory therapeutic agents and strategies.
Furnishing a comprehensive and up-to-date view of the expanding and interrelated components underlying asthma pathogenesis, Inflammatory Mechanisms in Asthma
describes how evidence on airway inflammation is obtained with invasive and noninvasive procedures, such as bronchoalveolar lavage and sputum analysis
reviews the complex interactions of inflammatory cells that contribute to chronic inflammation and bronchial hyperreactivity, including eosinophils, basophils, neutrophils, fibroblasts, epithelial cells, and macrophages
considers mast cells, cytokines, neural factors, leukotrienes, kinins, and other mediators that regulate the development, establishment, or resolution of asthma exacerbations
presents new information suggesting that airway changes in asthma can lead to remodeling or airway fibrosis
and more!
Enhanced with over 4700 references, tables, drawings, and photographs, this compelling investigation into the pathophysiology of asthma is an indispensable resource for pulmonologists, physiologists, immunologists, allergists, epidemiologists, biochemists, molecular biologists, and graduate and medical school students in these disciplines.
Table of Contents:
The Pathology of Fatal Asthma, Bronchoalveolar Lavage in Studies of Asthma, Calhoun Evidence from Induced Sputum, Mast Cell Proteases in Asthma, Mast Cell Cytokines in Allergic Inflammation, Church Airway Responses to Antigen in Asthmatic and Nonasthmatic Subjects, The Role of the Basophil in the Inflammatory Mechanisms of Asthma, Eosinophils: Granule Proteins, Eosinophil Activation in Asthma, Eosinophil Autacoids, Eosinophil Cytokines, Eosinophils in Asthma, Interactions Between Eosinophils and the Airway Epithelium, Neutrophils and Asthma, Allergen Recognition Sites in Immunoglobulin E from Patients with Asthma, T Cells in Asthma, Macrophages and Macrophage Diversity in Asthma, Antigen Presentation in the Asthmatic Lung, Gant Macrophage and Dendritic Cell Populations in Airway Tissues, Fibroblasts and the Extracellular Matrix in Asthma, Mediator Functions of Epithelial Cells, Epithelium as a Target, Airway Neuropeptides and Their Role in Inflammation, Neuroimmune Interactions in Airway Inflammation, Microvascular-Epithelial Exudation of Bulk Plasma in Airway Defense, Disease, and Repair, Neuroregulation of Mucosal Vasculature, Leukocyte-Endothelial Adhesion, Prostanoids, Leukotrienes, Adenosine: Its Contribution to Our Understanding of Asthma, Chemotaxis and Mechanisms of Cell Migration, The Early and Late Asthmatic Response to Allergen, Inflammatory Mechanisms of Aspirin-Sensitive Asthma, Inflammatory Mechanisms in Nocturnal Asthma, Inflammatory Mediators and Exercise-Induced Asthma, Mechanisms of Airway Hyperresponsiveness, Transcription Factors as Activators and Repressors of Gene Transcription: NK-RB and Glucocorticoid Receptors, Lower Airway Responses to Viruses.
