About the Book
This timely volume brings together the latest basic and clinical insights on the cellular and mediator mechanisms involved in the induction and persistence of airway dysfunction of asthma by over 90 experts in the field-paving the way for developing novel and more effective antiinflammatory therapeutic agents and strategies.
Furnishing a comprehensive and up-to-date view of the expanding and interrelated components underlying asthma pathogenesis, Inflammatory Mechanisms in Asthma
describes how evidence on airway inflammation is obtained with invasive and noninvasive procedures, such as bronchoalveolar lavage and sputum analysis
reviews the complex interactions of inflammatory cells that contribute to chronic inflammation and bronchial hyperreactivity, including eosinophils, basophils, neutrophils, fibroblasts, epithelial cells, and macrophages
considers mast cells, cytokines, neural factors, leukotrienes, kinins, and other mediators that regulate the development, establishment, or resolution of asthma exacerbations
presents new information suggesting that airway changes in asthma can lead to remodeling or airway fibrosis
and more!
Enhanced with over 4700 references, tables, drawings, and photographs, this compelling investigation into the pathophysiology of asthma is an indispensable resource for pulmonologists, physiologists, immunologists, allergists, epidemiologists, biochemists, molecular biologists, and graduate and medical school students in these disciplines.
Table of Contents:
The Pathology of Fatal Asthma, Alan L. James and Neil Carroll
Bronchoscopy, Anthony J. Frew and Ratko DjukanovicM
Bronchoalveolar Lavage in Studies of Asthma, Mark C. Liu and William J. Calhoun
Evidence from Induced Sputum, Peter G. Gibson and Frederick E. Hargreave
Mast Cell Proteases in Asthma, Andrew F. Walls
Mast Cell Cytokines in Allergic Inflammation, John Joseph Costa, Stephen J. Galli, and Martin K. Church
Airway Responses to Antigen in Asthmatic and Nonasthmatic Subjects, Stephen P. Peters, Joseph R. Shaver, James G. Zangrilli, and James E. Fish
The Role of the Basophil in the Inflammatory Mechanisms of Asthma, L. H. Thomas and J. A. Warner
Eosinophils: Granule Proteins, María-Cristina Seminario, Cheryl R. Adolphson, and Gerald J. Gleich
Eosinophil Activation in Asthma, Shinji Motojima, Takeshi Fukuda, and Sohei Makino
Eosinophil Autacoids, Anthony P. Sampson
Eosinophil Cytokines, Redwan Moqbel and Paige Lacy
Eosinophils in Asthma, Aparna Kumar and William W. Busse
Interactions Between Eosinophils and the Airway Epithelium, Clive Robinson and Julia E. Carver
Neutrophils and Asthma, L. Fabbri, Piera Boschetto, G. Caramori, and P. Maestrelli
Allergen Recognition Sites in Immunoglobulin E from Patients with Asthma, Rachel E. Snow, Caroline J. Chapman, and Freda K. Stevenson
T Cells in Asthma, Chris J. Corrigan
Macrophages and Macrophage Diversity in Asthma, Shoobha S. Daftary, William J. Calhoun, and Nizar N. Jarjour
Antigen Presentation in the Asthmatic Lung, Jonathan D. Edgeworth, Tak H. Lee, and Vanya Alasdair Gant
Macrophage and Dendritic Cell Populations in Airway Tissues, Patrick G. Holt and Andrew S. McWilliam
Fibroblasts and the Extracellular Matrix in Asthma, Anthony E. Redington, Patricia J. Sime, Peter H. Howarth, and Stephen T. Holgate
Mediator Functions of Epithelial Cells, Katharine Knobil and David B. Jacoby
Epithelium as a Target, Steven R. White and Alan R. Leff
Airway Neuropeptides and Their Role in Inflammation, Peter J. Barnes
Neuroimmune Interactions in Airway Inflammation, Karen E. Pedersen, Allen C. Myers, and Bradley J. Undem
Microvascular-Epithelial Exudation of Bulk Plasma in Airway Defense, Disease, and Repair, Carl G. A. Persson, J. S. Erjefält, M. Andersson, L. Greiff, and C. Svensson
Neuroregulation of Mucosal Vasculature, James N. Baraniuk and Howard M. Druce
Leukocyte-Endothelial Adhesion, Frank P. Bell, Brydon L. Bennett, and Anthony M. Manning
Prostanoids, Arthur N. Freed and Steven R. Kleeberger
Leukotrienes, Sven-Erik Dahlén
Adenosine: Its Contribution to Our Understanding of Asthma, Gerrard D. Phillips and Stephen T. Holgate
Chemotaxis and Mechanisms of Cell Migration, Janis K. Shute and Rabiâ Hidi
Kinins, Bruce L. Zuraw and Sandra C. Christiansen
The Early and Late Asthmatic Response to Allergen, Ketan K. Sheth and Robert F. Lemanske, Jr.
Inflammatory Mechanisms of Aspirin-Sensitive Asthma, S. M. Shuaib Nasser and Tak H. Lee
Inflammatory Mechanisms in Nocturnal Asthma, George C. Georges and Richard J. Martin
Inflammatory Mediators and Exercise-Induced Asthma, Sandra D. Anderson
Mechanisms of Airway Hyperresponsiveness, Paul M. O'Byrne
Transcription Factors as Activators and Repressors of Gene Transcription: NK-RB and Glucocorticoid Receptors, Ian M. Adcock and Robert Newton
Lower Airway Responses to Viruses, Philip G. Bardin, David J. Fraenkel, and Philip J. Bates
