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Home > Health, Relationships and Personal development > Family and health > Coping with personal, social and health topics > Coping with / advice about ageing > Functional Spectral Domain Optical Coherence Tomography Imaging.
Functional Spectral Domain Optical Coherence Tomography Imaging.

Functional Spectral Domain Optical Coherence Tomography Imaging.


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About the Book

Spectral Domain Optical Coherence Tomography (SDOCT) is a high-speed, high resolution imaging modality capable of structural and functional characterization of tissue microstructure. SDOCT fills a niche between histology and ultrasound imaging, providing non-contact, non-invasive backscattering amplitude and phase from a sample. Due to the translucent nature of the tissue, ophthalmic imaging is an ideal space for SDOCT imaging. Structural imaging of the retina has provided new insights into ophthalmic disease. The phase component of SDOCT images remains largely underexplored, though. While Doppler SDOCT has been explored in a research setting, it has yet to gain traction in the clinic. Other, functional exploitations of the phase are possible and necessary to expand the utility of SDOCT. Spectral Domain Phase Microscopy (SDPM) is an extension of SDOCT that is capable of resolving sub-wavelength displacements within a focal volume. Application of sub-wavelength displacement measurement imaging could provide a new method for non-invasive optophysiological measurement. This body of work encompasses both hardware and software design and development for implementation of SDOCT. Structural imaging was proven in both the lab and the clinic. Coarse phase changes associated with Doppler flow frequency shifts were recorded and a study was conducted to validate Doppler measurement. Fine phase changes were explored through SDPM applications. Preliminary optophysiology data was acquired to study the potential of sub-wavelength measurements in the retina. To remove the complexity associated with in-vivo human retinal imaging, a first principles approach using isolated nerve samples was applied using standard SDPM and a depthencoded technique for measuring conduction velocity. Results from amplitude as well as both coarse and fine phase processing are presented. In-vivo optophysiology using SDPM is a promising avenue for exploration, and projects furthering or extending this body of work are discussed.


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Product Details
  • ISBN-13: 9781243632234
  • Publisher: Proquest, Umi Dissertation Publishing
  • Publisher Imprint: Proquest, Umi Dissertation Publishing
  • Height: 254 mm
  • Weight: 426 gr
  • ISBN-10: 1243632232
  • Publisher Date: 01 Sep 2011
  • Binding: Paperback
  • Spine Width: 14 mm
  • Width: 203 mm


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Functional Spectral Domain Optical Coherence Tomography Imaging.
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Functional Spectral Domain Optical Coherence Tomography Imaging.
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