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Home > Art, Film & Photography > Australian Geneticists: David Sinclair, Alan O. Trounson, Marc Wilkins, David Sillence, Otto Frankel, John Shine, Charles Birch, Robin Holliday
Australian Geneticists: David Sinclair, Alan O. Trounson, Marc Wilkins, David Sillence, Otto Frankel, John Shine, Charles Birch, Robin Holliday

Australian Geneticists: David Sinclair, Alan O. Trounson, Marc Wilkins, David Sillence, Otto Frankel, John Shine, Charles Birch, Robin Holliday


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About the Book

Chapters: David Sinclair, Alan O. Trounson, Marc Wilkins, David Sillence, Otto Frankel, John Shine, Charles Birch, Robin Holliday, Allen Kerr. Source: Wikipedia. Pages: 38. Not illustrated. Free updates online. Purchase includes a free trial membership in the publisher's book club where you can select from more than a million books without charge. Excerpt: David A. Sinclair PhD is a biologist best known for his research on the biology of lifespan extension and driving research towards treating diseases of ageing. Sinclair is Professor of Pathology and Co-Director of the Paul F. Glenn Laboratories for the Biological Mechanisms of Aging at Harvard Medical School. Dr. Sinclair obtained a Bachelors of Science (Honors Class I) at the University of New South Wales, Sydney, and received the Australian Commonwealth Prize. In 1995, he received a Ph.D. in Molecular Genetics then worked as a postdoctoral researcher at MIT with Leonard Guarente before being recruited in 1999 to Harvard Medical School. One of Sinclair's discoveries was in the lab of Leonard Guarente where he identified the key role of rDNA circles or "ERCs" in determining the lifespan of yeast. Subsequent research showed that ERCs are unique to aging in a particular yeast strain, and not involved in aging in any other organisms. ERCs were subsequently shown to be suppressed by the SIR2 gene, the founding member of the sirtuin gene family, as well as deletion of the FOB1 gene. With Kevin Mills and Lenny Guarente, he also showed that the Sir2 protein relocalizes to DNA breaks and mediates repair. These two discoveries led his lab to discover that genomic instability induces changes in gene regulation may drive the aging process in mammals. In 2002, Sinclair's lab at Harvard discovered a key role of NAD biosynthesis in aging. In 2003, his lab published that nicotinamide is a non-competitive inhibitor of Sir2 and SIRT1, and proposed the molecule as a physiological regulator...More: http: //booksllc.net/?id=780485


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Product Details
  • ISBN-13: 9781157533887
  • Publisher: Books LLC
  • Publisher Imprint: Books LLC
  • Height: 152 mm
  • No of Pages: 40
  • Spine Width: 3 mm
  • Weight: 73 gr
  • ISBN-10: 1157533884
  • Publisher Date: 15 Sep 2010
  • Binding: Paperback
  • Language: English
  • Returnable: N
  • Sub Title: David Sinclair, Alan O. Trounson, Marc Wilkins, David Sillence, Otto Frankel, John Shine, Charles Birch, Robin Holliday
  • Width: 229 mm


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Australian Geneticists: David Sinclair, Alan O. Trounson, Marc Wilkins, David Sillence, Otto Frankel, John Shine, Charles Birch, Robin Holliday
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