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Home > Art, Film & Photography > Sulfonate Esters: Busulfan, Tosyl, Ethyl Methanesulfonate, Methyl Methanesulfonate, Methyl Fluorosulfonate, Methyl Trifluoromethansulfonate
Sulfonate Esters: Busulfan, Tosyl, Ethyl Methanesulfonate, Methyl Methanesulfonate, Methyl Fluorosulfonate, Methyl Trifluoromethansulfonate

Sulfonate Esters: Busulfan, Tosyl, Ethyl Methanesulfonate, Methyl Methanesulfonate, Methyl Fluorosulfonate, Methyl Trifluoromethansulfonate


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About the Book

Chapters: Busulfan, Tosyl, Ethyl Methanesulfonate, Methyl Methanesulfonate, Methyl Fluorosulfonate, Methyl Trifluoromethansulfonate, Mannosulfan, Alkyl Sulfonate. Source: Wikipedia. Pages: 26. Not illustrated. Free updates online. Purchase includes a free trial membership in the publisher's book club where you can select from more than a million books without charge. Excerpt: EU EMA:, US FDA: Busulfan (Myleran, GlaxoSmithKline, Busulfex IV, PDL BioPharma, Inc.) is a cancer drug, in use since 1959. Busulfan is a cell cycle non-specific alkylating antineoplastic agent, in the class of alkyl sulfonates. Its chemical designation is 1,4-butanediol dimethanesulfonate. Busulfan was the mainstay of the chemotherapeutic treatment of Chronic Myeloid Leukemia (CML) until it was displaced by the new gold standard, Imatinib, though it is still in use to a degree as a result of the drug's relative inexpense. Currently, its main uses are in bone marrow transplantation, especially in chronic myelogenous leukemia (CML), where it is used as a conditioning drug. Busulfan can control tumor burden but cannot prevent transformation or correct cytogenic abnormalities. Though not as common, it may also be used for Chronic Lymphocytic Leukemia (CLL). The drug was recently used in a study to examine the role of platelet-transported serotonin in liver regeneration. Myleran is supplied in white film coated tablets with 2mg of Busulfan per tablet. it is also used in the treatment of chronic lymphocytic leukemia Toxicity may include interstitial pulmonary fibrosis, hyperpigmentation, seizures, hepatic (veno-occlusive disease) and wasting syndrome. Phenytoin may be used concurrently to prevent the seizures. Levetiracetam, has shown efficacy for the prophylaxis against busulfan-induced seizures. Benzodiazepines can also be used for busulfan-induced seizures. 1,4-Butanediol dimethanesulfonate is listed by the IARC as a Group 1 carcinogen. Its mechanism of ...More: http: //booksllc.net/?id=29212


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Product Details
  • ISBN-13: 9781157515418
  • Publisher: Books LLC
  • Publisher Imprint: Books LLC
  • Height: 152 mm
  • Sub Title: Busulfan, Tosyl, Ethyl Methanesulfonate, Methyl Methanesulfonate, Methyl Fluorosulfonate, Methyl Trifluoromethansulfonate
  • Width: 229 mm
  • ISBN-10: 115751541X
  • Publisher Date: 15 Sep 2010
  • Binding: Paperback
  • Spine Width: 2 mm
  • Weight: 54 gr


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