In Vitro Maturation of Human Oocytes

The use of IVM in assisted reproductive technology continues to increase around the world. The major benefit of IVM is that significant numbers of oocytes can be collected from ovaries without recourse to ovarian stimulation. This reduces the costs, time, and risks associated with conventional IVF. Although initially limited to women with polycystic ovary syndrome who were at higher risk of problems following ovarian stimulation, IVM is increasingly used in women with normal ovulatory menstrual cycles. This authoritative text covers the current scientific knowledge of oocyte development and the understanding behind the techniques involved in the clinical application of IVM in assisted reproductive technologies. Short Contents

Table of Contents:
Oocyte growth in the ovary. Interaction of oocytes and somatic cells. In-vitro development of small ovarian follicles. Mechanism of oocyte maturation. Gene expression during oocyte maturation. Epigenetic modification during oocyte maturation. Maturation of primordial follicles - the next step. Polycystic ovaries and polycystic ovary syndrome. Clinical aspects of polycystic ovary syndrome. Prediction and prevention of ovarian hyperstimulation syndrome. Clinical problems associated with ovarian stimulation (excluding OHSS). IVM for the treatment of infertility with PCOS. The first steps on the era of IVM. FSH priming in IVM cycles. Combination of FSH and hCG priming in IVM cycles. IVM oocyte collection - similarities and differences with IVF. Endometrial preparation for IVM. Laboratory aspects of IVM. Follow-up of children born after IVM. How do we improve implantation rate following IVM? Maturation of immature oocytes in stimulated cycles. IVM as an alternative for poor responders. IVM as an alternative for over-responders. Combination of natural cycle IVF with IVM. IVM for fertility preservation. Bibliographies & Index

Review :
"[A]rguably the best guide to understanding Pakistan's view of India and the world... her presentation of Pakistan's own narrative is of great value for the Indian political class and the strategic community in developing a more successful strategy towards our very special neighbour to the west." - C. Raja Mohan, Border Forces; indianexpress.com "Pande's Explaining Pakistan's Foreign Policy: Escaping India is a worthy read. An accessible academic text, Pande's book describes the logic and evolution of Pakistan's foreign policy, showing how much of it is grounded in pre-Partition tensions between the Muslim League and Congress. She shows how India's Muslim elite constructed an Islamic identity to differentiate themselves from "Hindu" India in order to buttress the two-nation theory. To some extent, Pande's task is easy, since few will deny her basic argument that Pakistan's foreign policy is India-centric. Her choice to revisit the historical underpinnings of that India-centricity is what makes the book an interesting read... Pande's account is ultimately a balanced review of Pakistan's foreign policy imperatives that simultaneously justifies Islamabad's concerns while highlighting the fallout of clinging to them too closely." - Huma Yusuf; Dawn Magazine, September 18, 2011 "Offering a comprehensive and probing analysis of the country's foreign policy since 1947, Pande, a South Asia scholar and analyst, describes how Pakistanis have constructed their national identity and how closely it is tied to their views of national survival." - Dr. Marvin G. Weinbaum,Director of the Center for Pakistan Studies at the Middle East Institute; The Middle East Journal (Vol. 65, No. 4) "Aparna Pande's excellent book, Explaining Pakistan's Foreign Policy: Escaping India, is a must read for Indian travellers to Pakistan who tend to gush to the locals, "You know, this is just like India, we don't feel like we've come to another country", and then feel perplexed by the Lahori's cold response... a carefully researched historical analysis that traces the crafting of our neighbour's national identity, from the time that the Muslim League convinced itself that a nation could be constructed on the basis of a shared religious identity, with Islam substituting for nationalism." - Ajai Shukla; Business Standard, June 27th 2012