Stem Cells, Craniofacial Development and Regeneration is an introduction to stem cells with an emphasis on their role in craniofacial development. Divided into five sections, chapters build from basic introductory information on the definition and characteristics of stem cells to more indepth explorations of their role in craniofacial development. Section I covers embryonic and adult stem cells with a focus on the craniofacial region, while sections II-IV cover the development and regeneration of craniofacial bone, tooth, temporomandibular joint, salivary glands and muscle. Concluding chapters describe the current, cutting-edge research utilizing stem cells for craniofacial tissue bioengineering to treat lost or damaged tissue. The authoritative resource for dentistry students as well as craniofacial researchers at the graduate and post-graduate level, Stem Cells, Craniofacial Development and Regeneration explores the rapidly expanding field of stem cells and regeneration from the perspective of the dentistry and craniofacial community, and points the way forward in areas of tissue bioengineering and craniofacial stem cell therapies.
Table of Contents:
Contributors xi
Preface xv
PART I DEVELOPMENT AND REGENERATION OF CRANIOFACIAL TISSUES AND ORGANS
1 Molecular Blueprint for Craniofacial Morphogenesis and Development 3
Paul A. Trainor
2 Cranial Neural Crest Cells in Craniofacial Tissues and Organs 31
Carolina Parada and Yang Chai
3 Craniofacial Intramembranous Bone Development and Regeneration 51
David P. Rice and Ritva Rice
4 Temporomandibular Joint Development 71
Shuping Gu and YiPing Chen
5 Craniofacial Muscle Development 87
Robert G. Kelly
6 Tooth Morphogenesis and Renewal 109
Maria Jussila, Emma Juuri, and Irma Thesleff
7 Reptilian Tooth Regeneration 135
Joy M. Richman, John A. Whitlock, and John Abramyan
8 Tooth Root Development 153
Brian L. Foster, Francisco H. Nociti Jr., and Martha J. Somerman
9 Systems Biology of Early Tooth Development 179
Daniel J. O’Connell, Joshua W. K. Ho, and Richard L. Maas
PART II STEM CELLS AND THEIR NICHES IN CRANIOFACIAL TISSUES
10 Stem Cells, Induced Pluripotent Stem Cells, and Their Differentiation to Specified Lineage Fates 205
George T.-J. Huang, Xiao-Ying Zou, Xing Yan, Kyle J. Hewitt, Yulia Shamis, and Jonathan A. Garlick
11 Bone Marrow Mesenchymal Stem Cells 223
Songtao Shi and Stan Gronthos
12 Adipose Tissue–Derived Stem Cells and Their Regeneration Potential 241
Jeffrey Gimble, Maryam Rezai Rad, and Shaomian Yao
13 Skeletal Muscle Stem Cells: Their Origin and Niche Factors 259
Johannes W. Von den Hoff and Sander Grefte
14 Stem Cells in Salivary Gland Development and Regeneration 271
Isabelle M. A. Lombaert and Matthew P. Hoffman
15 Stem and Progenitor Cells of Dental and Gingival Tissue Origin 285
Christian Morsczeck, George T.-J. Huang, and Songtao Shi
16 Regulation and Differentiation Potential of Dental Mesenchymal Stem Cells 303
Lei Wang, Christian Morsczeck, Stan Gronthos, and Songtao Shi
17 An Incisive Look at Stem Cells: The Mouse Incisor as an Emerging Model for Tooth Renewal 315
Frederic Michon, Andrew H. Jheon, Kerstin Seidel, and Ophir D. Klein
18 Mesenchymal Stem Cell Niches in Rodent Tooth Pulp 329
Jifan Feng and Paul T. Sharpe
PART III STEM CELL–MEDIATED CRANIOFACIAL TISSUE BIOENGINEERING
19 Bone Bioengineering: Scaffolds, Growth Factors, and Stem Cells 341
Christopher S. D. Lee, Christopher D. Hermann, Rolando Gittens, Rene Olivares-Navarrete, Zvi Schwartz, and Barbara D. Boyan
20 Craniofacial Tissue Bioengineering and Regeneration by Endogenous Stem Cells 367
Nan Jiang, Mo Chen, Chang Hun Lee, Jian Zhou, Mildred C. Embree, Kimi Kong, Choko Cho, Avital Mendelson, Ying Zheng, Hemin Nie, and Jeremy J. Mao
21 Stem Cell–Based Bioengineering of Craniofacial Bone 379
David D. Lo, Daniel T. Montoro, Monica Grova, Jeong S. Hyun, Michael T. Chung, Derrick C. Wan, and Michael T. Longaker
22 Muscle Tissue Engineering Approaches 395
Johannes W. Von den Hoff and Sander Grefte
23 Engineering of Dental Tissues: Scaffolds and Preclinical Models 409
Na Yu, Adelina Plachokova, Fang Yang, X. Frank Walboomers, and John A. Jansen
24 Whole-Tooth Engineering and Cell Sources 431
L. Keller, S. Kuchler-Bopp, and Herv´e Lesot
25 Bioengineering of Functional Teeth 447
Takashi Tsuji
26 Pulp and Dentin Regeneration 461
Misako Nakashima and George T.-J. Huang
27 Bioengineering of Roots and Periodontal Tissues 485
Songlin Wang, Gang Ding, Fulan Wei, and Yi Liu
28 Periodontal Bioengineering Strategies: The Present Status and Some Developing Trends 501
Fa-Ming Chen and Yan Jin
Index 525
About the Author :
George T.-J. Huang, DDS, MSD, DSc, is the Director for Stem Cells and Regenerative Therapies in the College of Dentistry at the University of Tennessee Health Science Center.
Irma Thesleff, DDS, PhD, is the Research Director of the Developmental Biology Program at the Institute of Biotechnology at the University of Helsinki.
