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Home > Science, Technology & Agriculture > Industrial chemistry and manufacturing technologies > Industrial chemistry and chemical engineering > Food and beverage technology > Anticancer Agents: Frontiers in Cancer Chemotherapy(No. 796 ACS Symposium Series)
Anticancer Agents: Frontiers in Cancer Chemotherapy(No. 796 ACS Symposium Series)

Anticancer Agents: Frontiers in Cancer Chemotherapy(No. 796 ACS Symposium Series)


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About the Book

Describes cutting edge approaches in the development of anticancer agents for chemotherapy. These new and interdisciplinary approaches are aimed at the development of tumor specific anticancer agents while increasing the potency against drug-resistant tumors. The volume includes an overview of new paradigms for cancer drug discovery and development by NCI, new generation cytotoxic agents, mechanism based enzyme inhibitors as anticancer agents, anti-angiogenesis agents, antitumor vaccins, and tumor activated prodrugs using immunoconjugates of monoclonal antibodies with cytotoxic agents.

Table of Contents:
Preface ; 1. Cancer Drug Discovery and Development: New Paradigms for a New Millennium ; 2. Evolutionary Biosynthesis of Anticancer Drugs ; 3. Some Recent Developments in the Synthesis and SAR of Novel Taxanes ; 4. New Generation Taxoids and Hybrids of Microtube-Stabilizing Anticancer Agents ; 5. Discodermolide and Taxol: A Synergistic Drug Combination in Human Carcinoma Cell Lines ; 6. Highly Efficient Semisynthesis of Biologically Active Epothilone Derivatives ; 7. Synthetic and Semisynthetic Analogs of Epothilones: Chemistry and Biological Activity ; 8. Synthesis and Biological Activity of Epothilones ; 9. Epothelones and Sarcodictyins: From Combinatorial to Designed Analogs ; 10. Synthesis and Structure-Activity Relationship Studies of Cryptophycins: A Novel Class of Potent Antimitotic Tumor Depsipeptides ; 11. Farnesyltransferase Inhibitors as Potential Anticancer Agents ; 12. Farnesyltransferase Inhibitors: From Squalene Synthase Inhibitors to the Clinical Agent BMS-214662 ; 13. Inhibiting Farnesyl Protein Transferase with Sch-66336: Potentially a Selective Non-Cytotoxic herapy for Human Cancer ; 14. Pyrrolo[2,3-d]pyrimidine and Pyrazolo[3,4-d]pyrimidine Derivatives as Selective Inhibitors of the EGF Receptor Tyrosine Kinase ; 15. STI571: A New Treatment Modality for CML ; 16. The Discovery and Development of Second-Generation Matrix Metalloproteinase Inhibitors for the Treatment of Cancer ; 17. Prospects for Anti-Angiogenic Therapies Based upon VEGF Inhibition ; 18. Carbohydrate-Based Tumor Antigens as Anti-Tumor Vaccine Agents ; 19. Drugs to Enhance the Therapeutic Potency of Anti-Cancer Antibodies ; Author Index

Review :
"These 19 articles were mostly drawn from the American Chemical Society's March 2000 symposium entitled "New Prospects in Anticancer Agents for the 21st Century," organized by managing editor Ojima (chemistry, State U. of New York, Stonybrook). The material covers a range of topics including the National Cancer Institute's new paradigms for cancer drug discovery and development; various statins from marine natural products; new generation taxoids and other microtubule-interacting anticancer agents; the potentially tumor specific mechanism-based agents; inhibitors of signaling pathway; anti angiogenesis agents including matrix metalloproteinase inhibitors, VEGF inhibitors; Abl tyrosine kinase inhibitors that exhibit promise against chronic myeloid leukemia; antitumor vaccines; and tumor activated prodrugs combining monoclonal antibody and cytotoxic agents."--SciTech Book News


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Product Details
  • ISBN-13: 9780841237452
  • Publisher: Oxford University Press Inc
  • Publisher Imprint: Oxford University Press Inc
  • Height: 236 mm
  • No of Pages: 380
  • Series Title: No. 796 ACS Symposium Series
  • Sub Title: Frontiers in Cancer Chemotherapy
  • Width: 157 mm
  • ISBN-10: 084123745X
  • Publisher Date: 25 Jul 2002
  • Binding: Hardback
  • Language: English
  • Returnable: N
  • Spine Width: 23 mm
  • Weight: 761 gr


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