Group Sequential and Adaptive Methods for Clinical Trials, Second Edition
Group Sequential and Adaptive Methods for Clinical Trials, Second Edition: (Chapman & Hall/CRC Interdisciplinary Statistics)

Group Sequential and Adaptive Methods for Clinical Trials, Second Edition: (Chapman & Hall/CRC Interdisciplinary Statistics)


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About the Book

Table of Contents:
1. Introduction. 2. Two-sided Tests: Introduction. 3. A Unified Formulation and the General Calculation. 4. Two-sided Tests: General Applications. 5. One-Sided Tests. 6. Two-Sided Tests with Early Stopping Under the Null Hypothesis. 7. Tests for Equivalence and Non-inferiority. 8. Information Monitoring: The Error Spending Approach. 9. Analysis Following a Sequential Test. 10. Repeated Coincidence Intervals. 11. Stochastic Curtailment. 12. Optimal Group Sequential Tests. 13. Bayesian Approaches. 14. Group Sequential Tests for Delayed Observations. 15. General Group Sequential Distribution Theory. 16. Binary Data. 17. Survival Data. 18. Nuisance Parameters: Internal Pilot Studies, Sample Size Re-estimation and Information Monitoring. 19. Multivariate Endpoints. 20. Multiple Hypotheses: Primary and Secondary Endpoints. 21. Multi-arm Multi-stage Trials. 22. From Group Sequential to Adaptive Designs: Flexible Sample Size Re-assessment. 23. Adaptive Combination Tests. 24. Sample Size Re-assessment given an Interim Estimate of Treatment Effect . 25. Adaptive Trials Testing Multiple Hypotheses: Closed Testing Procedures with Combination Tests. 26. Treatment Selection and Testing: Seamless Phase II/III Trials. 27. Adaptive Multi-arm Multi-stage Phase III Trials. 28. Enrichment Designs: Targeting Therapies to Selected Sub-populations. 29. Adaptive Seamless Design: A Case Study with Intermediate and Long- Term Survival Endpoints. 30. Response Adaptive Treatment Assignment. 31. Numerical Computations for Group Sequential and Adaptive Tests.

About the Author :
Christopher Jennison is Professor of Statistics in the Department of Mathematical Sciences, University of Bath, UK. He has worked on the analysis of clinical trials at the Dana-Farber Cancer Institute, Boston and collaborated with medical researchers in areas such as cancer research, cardiology, gynaecology, and complementary medicine. Bruce Turnbull is Emeritus Professor of Statistics in the School of Operations Research & Industrial Engineering and in the Department of Statistical Science, Cornell University, USA. He has a long experience of designing, monitoring, and analyzing clinical trials and has served on the Data Safety Monitoring Boards for international, multi-center trials for the treatment or prevention of cancer, heart disease and AIDS. He has also served as a consultant to pharmaceutical companies and health-related government review panels.


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Product Details
  • ISBN-13: 9780429646997
  • Publisher: Taylor & Francis Ltd
  • Publisher Imprint: Chapman & Hall/CRC
  • Edition: New edition
  • No of Pages: 512
  • Series Title: Chapman & Hall/CRC Biostatistics Series
  • ISBN-10: 0429646992
  • Publisher Date: 03 Jul 2022
  • Binding: Digital (delivered electronically)
  • Language: English
  • No of Pages: 512


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Group Sequential and Adaptive Methods for Clinical Trials, Second Edition: (Chapman & Hall/CRC Interdisciplinary Statistics)
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