Adaptive Design Methods in Clinical Trials
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Adaptive Design Methods in Clinical Trials: (Chapman & Hall/CRC Biostatistics Series)

Adaptive Design Methods in Clinical Trials: (Chapman & Hall/CRC Biostatistics Series)


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About the Book

Although adaptive design methods are flexible and useful in clinical research, little or no regulatory guidelines are available. One of the first books on the topic, Adaptive Design Methods in Clinical Trials presents the principles and methodologies in adaptive design and analysis that pertain to adaptations made to trial or statistical procedures

Table of Contents:
Introduction. Protocol Amendment. Adaptive Randomization. Adaptive Hypotheses. Adaptive Dose-Escalation Trials. Adaptive Group Sequential Design. Adaptive Sample Size Adjustment. Adaptive Seamless Phase II/III Designs. Adaptive Treatment Switching. Bayesian Approach. Clinical Trial Simulation. Case Studies.

Review :
"The authors are to be commended for the endeavour to provide a monograph about this rapidly evolving area in- to our knowledge- the first book specifically devoted to adaptive design methods . . . we think it provides a valuable contribution to the area of adaptive design." – Frank Miller and Stig Johan Wiklund, Clinical Information Science, Biostatistics, AstraZeneca, in Statistical Medicine, 2008, Vol. 27 "In summary, this is an extremely useful book for clinical trials statisticians wishing to stay abreast with the innovative approaches that are being developed amid some controversies regarding their benefits." – Yuko Palesch, Medical University of South Carolina, in Journal of the American Statistical Association, March 2008, Vol. 103, No. 481 "…This book is one of the first of its kind to be released solely dealing with adaptive designs in clinical trials. … a useful reference for those who have a mathematical background and wish to understand some of the adaptive design methodologies. …With the ever-increasing need for adaptive trials, we could see this book having a large influence …" —Pharmaceutical Statistics, 2008 "…a useful reference source for anyone interested in advancing innovative trial designs and wishing to incorporate adaptations, modifications, and changes to the drug, device, and biological developmental processes." —C.M. O’Brien, International Statistical Review, Vol. 75, No. 2, 2007 "…uses a broad definition of adaptive design methods… .This breadth of coverage is to be commended and makes the book a useful reference and overview for anyone who is starting to explore this area … the book is worth reading." —Angela Wade, University College London, UK "The book covers a vast area. To my knowledge this book is the first attempt to provide a concise description of various methodologies in a highly dynamic area. The authors deserve to be praised for bringing this huge range of approaches, including very recent trends, together in one book … ." —Tim Friede, University of Warwick, Biometrics, March 2008


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Product Details
  • ISBN-13: 9781584887775
  • Publisher: Taylor & Francis Ltd
  • Publisher Imprint: Chapman & Hall/CRC
  • Language: English
  • No of Pages: 296
  • ISBN-10: 158488777X
  • Publisher Date: 16 Nov 2006
  • Binding: Digital (delivered electronically)
  • No of Pages: 296
  • Series Title: Chapman & Hall/CRC Biostatistics Series


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