Control of Breathing during Sleep: From Bench to Bedside

This book describes control of ventilation during sleep in both health and disease states. The topics are presented in a fashion that can be easily comprehended with many figures to illustrate complex concepts. Thus, a wide range of topics, starting from the site of normal respiratory rhythm generation to chemoreceptor control of sleep apnea, description of the apneic threshold, pathophysiology of upper airway closure, novel techniques to measure control of breathing, effect of cerebral blood flow on breathing, effect of opioids on ventilation, effect of heart failure on ventilation, genetic aspects of breathing disorders, age and gender differences, and various therapies are discussed. Key Features • Helps to bridge the gap between straight forward physiology and clinical practice through a range of topics and use of case vignettes • Explores various aspects of clinical management and control which is beneficial to sleep clinicians, respiratory physiologists, intensivists, trainees, and researchers. • Distills complex concepts into understandable language and figures, providing helping resource to the clinicians, that transforms a dry topic vis a viz control of ventilation into an exciting understandable ‘clinician’ language.

Table of Contents:
Foreword. Preface. About the Editors. List of Contributors. ANATOMY, DEVELOPMENT, AGING, AND MECHANISMS OF CONTROL OF VENTILATION. Anatomy of the Respiratory Neural Network. Chemoreception: Pathways, Plasticity, and Pathophysiology. Developmental Changes in the Respiratory System of the Neonate-Child. Control of Breathing in Older Adults. Breathing Control in Exercise. Control of the Upper Airway during Sleep. PATHOPHYSIOLOGY OF SLEEP-DISORDERED BREATHING. Pathophysiology of Sleep-Disordered Breathing in Children and Neonates. Pathogenesis of Sleep-Disordered Breathing in Adults: Overview. Risk and Causality by Genetics, Gender, and Age. The Influence of Cerebral Blood Flow and Cerebrovascular Responsiveness on Ventilatory Control. Central Apnea: Propensity and Plasticity. SLEEP-DISORDERED BREATHING IN DIFFERENT CONDITIONS AND DISEASE STATES. Sleep-Disordered Breathing due to Heart Failure. Breathing at Altitude. Sleep-Disordered Breathing Associated with Chronic Lung Diseases. Obesity Hypoventilation Syndrome. PATHOPHYSIOLOGY-DIRECTED THERAPIES FOR SLEEP-DISORDERED BREATHING. Effect of Positive Airway Pressure on Ventilatory Control and Sleep-Disordered Breathing. Mild Intermittent Hypoxia and Supplemental Oxygen: Potential Therapeutic Interventions to Treat Breathing Instability. Pharmacological Management of Sleep-Disordered Breathing. Neural Mechanisms Regulating Opioid-Induced Respiratory Depression and Therapeutic Strategies to Alleviate the Respiratory Side-Effects of Opioid Drugs. Pharmacologic Intervention Studies to Mitigate Breathing Instability – Animal Studies. Index.

About the Author :
Dr. Susmita Chowdhuri, M.D., M.S. is a Professor of Internal Medicine at Wayne State University School of Medicine and a Staff Physician and the Section Chief of Sleep Medicine at the John D. Dingell VA Medical Center in Detroit, Michigan. Dr. M. Safwan Badr, M.D., M.B.A. is a Professor and Chair of Internal Medicine at Wayne State University School of Medicine and a Staff Physician at the John D. Dingell VA Medical Center. Dr. James A Rowley is a Professor of Medicine and Division Chief of Pulmonary/Critical Care and Sleep mMdicine at Wayne State University School of Medicine in Detroit, Michigan.

Review :
This book provides an excellent overview of pathophysiology and treatment options associated with management of one of the core problems of pulmonary medicine. Reference lists allow effective secondary literature review. Illustrations clearly support presentations made. This is a worthy tool for intensivists and pulmonary providers at all levels of sophistication. - David James Dries, MSE, MD, Regions Hospital