Antisense Technology in the Central Nervous System
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Antisense Technology in the Central Nervous System

Antisense Technology in the Central Nervous System


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About the Book

Antisense technology has been used for several years to "knock down" the expression of specific genes in living tissues to study the functions of their protein products. Specifically designed antisense oligonucleotides (ODNs) are short lengths of man-made genetic material designed to interfere with the production of the protein encoded by the gene. This can shed light on the function of the protein; alternatively, if a disease process results from an excess of a certain protein, the method can in theory correct the problem. Although faster than transgenic techniques, antisense has been seen as something of a "black art". There are many technical problems to understand and overcome. This is the first book to provide a critical review of the uses of this technology in the central nervous system. It includes: Background to the technology Problems of design and synthesis of antisense molecules Administration in the brain Protection of ODNs from metabolic destruction

Table of Contents:
1. Antisense oligonucleotide regulation of gene expression in the CNS: an overview; 2. Antisense knockdown in the CNS - optimizing the strategy; 3. The design of appropriate control experiments to ensure specificity in antisense oligonucleotide function; 4. Modulation of gene expression in the central nervous system as a tool in behavioral pharmacology; 5. Behavioural and neuroendocrine effects of antisense targeting in the rat; 6. Electrophysiological and behavioural effects of dopamine receptor knockdown in the brain; 7. Medicinal chemistry of antisense oligonucleotides; 8. Retinal neuronal development in trkB antisense 'knockdowns'; 9. Pluronic gel as a means of antisense delivery

Review :
...This is the first book to provide a critical review of the uses of this technology in the central nervous system Aslib Book Guide


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Product Details
  • ISBN-13: 9780198505389
  • Publisher: Oxford University Press
  • Binding: Paperback
  • ISBN-10: 0198505388
  • Publisher Date: 01 Nov 1999
  • Language: English


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