About the Book
The Handbook of Biomedical Nonlinear Optical Microscopies provides comprehensive treatment of the theories, techniques, and biomedical applications of nonlinear optics and microscopy for cell biologists, life scientists, biomedical engineers, and clinicians. The chapters are separated into basic and advanced sections, and provide both textual and graphical illustrations of all key concepts. The more basic sections are aimed at life scientists without advanced training in physics and mathematics, and tutorials are provided for the more challenging sections.
The first part of the Handbook introduces the historical context of nonlinear microscopy. The second part presents the nonlinear optical theory of two- and multiphoton excited fluorescence (TPE, MPE) spectroscopy, second and third harmonic generation (SHG, THG) spectroscopy, and coherent anti-Stokes Raman spectroscopy (CARS). The third part introduces modern microscopic and spectroscopic instrumentation and techniques that are based on nonlinear optics. The fourth part provides key applications of nonlinear microscopy to the biomedical area: neurobiology, immunology, tumor biology, developmental biology, dermatology, and cellular metabolism. There are also chapters on nonlinear molecular probes, cellular damage, and nanoprocessing.
Table of Contents:
List of Contributors
Watt Webb: Foreword
Part I. Historical Development of Nonlinear Optical Spectroscopy and Microscopy
Barry R. Masters: Introduction to Part I: Historical Development of Nonlinear Optical Microscopy and Spectroscopy
Chapter 1: Barry R. Masters and Peter T. C. So: The Genesis of Nonlinear Optical Microscopies and Their Impact on Modern Developments
Chapter 2: Barry R. Masters: The Scientific Life of Maria Göppert-Mayer
Chapter 3: Barry R. Masters: The History of Perturbation Theory from Astronomy to Quantum Mechanics
Chapter 4: Barry R. Masters: English Translations of and Translator's Notes on Maria Göppert-Mayer's Theory of Two-Quantum Processes
Part II. Nonlinear Optical Spectroscopy
Robert W. Boyd and Barry R. Masters: Introduction to Part II: Nonlinear Optical Spectroscopy
Chapter 5: Barry R. Masters and Peter T. C. So: Classical and Quantum Theory of One-Photon and Multiphoton Fluorescence Spectroscopy
Chapter 6: Robert W. Boyd: Second- and Higher-Order Harmonic Generation
Chapter 7: Eric O. Potma and X. Sunney Xie: Theory of Spontaneous and Coherent Raman Scattering
Part III. Nonlinear Optical Instruments for Microscopic Imaging and Analysis
Peter T. C. So and Daekeun Kim: Introduction to Part III: Nonlinear Optical Instruments for Microscopic Imaging and Analysis: Review and Forecast
Chapter 8: John Girkin: Laser Sources for Non-Linear Microscopy
Chapter 9: Peter T.C. So and Daekeun Kim: Ultrashort Optical Pulse Delivery for Nonlinear Optical Microscopy
Chapter 10: Peter T. C. So and Daekeun Kim: An Optical Design Primer for Nonlinear Optical Microscopy
Chapter 11: Min Gu: Image Formation in Multiphoton Fluorescence Microscopy
Chapter 12: Siavash Yazdanfar and Peter T. C. So: Signal Detection and Processing in Nonlinear Optical Microscopes
Chapter 13: Chris Xu and Warren R. Zipfel: Multiphoton Excitation of Fluorescent Probes
Chapter 14: Karsten König: Multiphoton-Induced Cell Damage
Chapter 15: Jerome Mertz: Applications of Second-Harmonic Generation Microscopy
Chapter 16: Paul J. Campagnola: Second-Harmonic Generation Imaging Microscopy of Structural Protein
Chapter 17: Eric O. Potma and X. Sunney Xie: Coherent Anti-Stokes Raman Scattering (CARS) Microscopy: Instrumentation and Applications
Chapter 18: Ki H. Kim, Karsten Bahlmann, Timothy Ragan, Daekeun Kim, and Peter T. C. So: High-speed Imaging Using Multiphoton Excitation
Chapter 19: Sebastian Wachsmann-Hogiu and Daniel L. Farkas: Nonlinear Multi-Spectral Optical Imaging Microscopy: Concepts, Instrumentation, and Applications
Chapter 20: Yen Sun, Wen Lo, Jiunn Wen Su, Sung-Jan Lin, Shiou-Hwa Jee, and Chen-Yuan Dong: Multiphoton Polarization Microscopy
Chapter 21: Wolfgang Becker and Axel Bergmann: Lifetime-Resolved Imaging in Nonlinear Microscopy
Chapter 22: Barry R. Masters and Peter T. C. So: Förster Resonance Energy Transfer (FRET)
Chapter 23: Ye Chen, Horst Wallrabe and Ammasi Periasamy: Two-Photon Förster Resonance Energy Transfer (FRET) Microscopy
Chapter 24: Andreas Schönle, Jan Keller, Benjamin Harke, and Stefan W. Hell: Diffraction Unlimited Far-Field Fluorescence Microscopy
Chapter 25: Suzette Pabit and Keith Berland: Two-Photon Fluorescence Correlation Spectroscopy
Chapter 26: Edward Brown, Ania Majewska, and Rakesh K. Jain: Photobleaching and Recovery with Nonlinear Microscopy
Chapter 27: Karsten König: Femtosecond Laser Nanoprocessing
Part IV. Biomedical Applications of Nonlinear Optical Microscopy
Bruce J. Tromberg: Introduction to Part IV: Biomedical Applications of Nonlinear Optical Microscopy
Chapter 28: Q.-T. Nguyen, G. O. Clay, N. Nishimura, C. B. Schaffer, L. F. Schroeder, P. S. Tsai, and D. Kleinfeld: Pioneering Applications Of Two-Photon Microscopy To Mammalian Neurophysiology: Seven Case Studies
Chapter 29: Rakesh K. Jain, Michael F. Booth, Timothy P. Padera, Lance L. Munn, Dai Fukumura, and Edward Brown: Applications of Non-Linear Intravital Microscopy in Tumor Biology
Chapter 30: Ian Parker and Michael D. Cahalan: Immunology Based on Nonlinear Optical Microscopy
Chapter 31: Irina V. Larina and Mary E. Dickinson: Multiphoton Imaging in Animal Development
Chapter 32: Barry R. Masters and Peter T. C. So: Nonlinear Microscopy Applied to Dermatology
Chapter 33: Barry R. Masters: Cellular Metabolism Monitored by NAD(P)H Imaging with Two-Photon Excitation Microscopy
Index
About the Author :
Professor Peter T. C. So is a Professor of Mechanical Engineering and Biological Engineering at the Massachusetts Institute of Technology (MIT), Cambridge, MA. He received a B.S. degree in physics and mathematics in 1986 from the Harvey Mudd College and a Ph.D. degree in physics in 1992 from Princeton University. Professor So joined MIT as a faculty member in 1996. Professor So has published over 75 research papers in refereed journals, over 30
refereed conference proceedings, many book chapters, and numerous scientific abstracts. He is also the co-inventor of five patents related to microscopy and instrumentation.
Barry R. Masters is a visiting scientist in the Department of Biological Engineering
at the Massachusetts Institute of Technology and a visiting scholar in the Department
of the History of Science at Harvard University. He was formerly a professor in anatomy at the Uniformed Services University of the Health Sciences. He is a Fellow of the Optical Society of America (OSA), the International Society for Optical Engineering (SPIE), and the American Association for the Advancement of Science (AAAS). Professor Masters has published 81 refereed research papers and 128 book chapters and articles. He is the editor or author of Noninvasive Diagnostic Techniques
in Ophthalmology; Medical Optical Tomography: Functional Imaging and Monitoring; Selected Papers on Confocal Microscopy; Selected Papers on Optical Low-Coherence Reflectometry and Tomography; Selected Papers
on Multiphoton Excitation Microscopy; Confocal Microscopy and Multiphoton Excitation Microscopy: the Genesis of Live Cell Imaging; and with Peter So, Handbook of Biomedical Nonlinear Optical Microscopy. Professor Masters is a member of the editorial board of Graefe's Archive for Clinical and Experimental Ophthalmology. His research interests include the development of in vivo microscopy of the human eye and skin, biomedical imaging and spectroscopy, and the fractal
analysis of branching vascular patterns.
Review :
The Handbook of Biomedical Nonlinear Optical Microscopy will be invaluable for anyone who plans to enter this complex and rapidly developing field and it will be a useful reference for experienced researchers as well."-- Journal of Biophotonics
"A guide for the field of nonlinear optical spectroscopy and microscopy has emerged with the publication of a conceptually interesting, information-rich, well-written, comprehensive, current, and eminently practical handbook. It deserves a place on the bookshelf of every researcher considering or conducting biomedical optical studies."--William W. Mantulin, Journal of Biomedical Optics
"Professors Masters and So have done an excellent job organizing the chapters of this book and choosing the scientists, whose contributions are excellent. The first part is a"must" read. The way the book is written, even if the reader wants to focus only on the applications presented, it is possible to understand the application chapters as stand-along papers as they are edited to contain clear, detailed text, with the figures and supporting references one
expects from a handbook. I strongly recommend this book to scientists with any scientific background who are involved with nonlinear microscopies." -- Dr. Susana A. Sanchez for Microscopy and Microanalysis
