Handbook of Diagnostic Endocrinology

The clinical laboratory plays a critical role in the diagnosis and management of endocrine and related metabolic disorders, which are leading causes of morbidity and mortality in children and adults. The Handbook of Diagnostic Endocrinology, Third Edition, provides a ready reference for the evaluation, diagnosis, and monitoring of such disorders. This revision incorporates translational medicine, connecting what clinicians need to know with those in research providing a clinical context to which they can relate their molecular findings. This book solves the needs of clinicians and researchers by bringing together in one book endocrinology at the molecular and clinical levels. As the intricacies of intracellular signaling have become better understood, states of hormone resistance are now increasingly recognized. The most common endocrinopathy in westernized countries, the metabolic syndrome, results, to a large extent, from insulin resistance. The complexity of the circulating forms of various hormones are acknowledged in this revision.

Table of Contents:
1. Maximizing the value of laboratory tests Raffick A.R. Bowen, Roger L. Bertholf and Brett Holmquist 2. Laboratory investigation of disorders of the pituitary gland Verena Gounden, Charlotte C. Ellberg and Ishwarlal Jialal 3. Thyroid disease and laboratory assessment Sridevi Devaraj and Emily Garnett 4. Disorders of the adrenal gland Roger L. Bertholf 5. Endocrine disorders of the reproductive system Angela M. Ferguson and Mark A. Cervinski 6. Gastroenteropancreatic tumors Neeraj Ramarishnan, Seong Hyun Ahn and Ishwarlal Jialal 7. Evaluation of hypoglycemia William E. Winter and Neil S. Harris 8. Evaluation of hyperglycemia William E. Winter, David L. Pittman, Sridevi Devaraj, Danni Li and Neil S. Harris 9. Lipoproteins Anna Wolska and Alan T. Remaley 10. Disorders of calcium metabolism William E. Winter and Neil S. Harris 11. Laboratory evaluation of endocrine hypertension William E. Winter and Neil S. Harris 12. Malignancy-associated endocrine disorders Lori J. Sokoll and Daniel W. Chan 13. Laboratory assessment of acquired immunodeficiency syndrome endocrinopathies Verena Gounden and Manisha Chandalia 14. Laboratory evaluation of short stature in children William E. Winter 15. Pregnancy and the fetus K. Aaron Geno, Mark A. Cervinski and Robert D. Nerenz 16. Disorders of sexual development William E. Winter, Paul Hiers and Dina N. Greene 17. Transgender endocrinology Dina N. Greene, Tamar Reisman and Zil Goldstein 18. The endocrinology of aging Daniel T. Holmes and Gregory Kline

About the Author :
Dr. Winter is a professor of pathology, immunology, and laboratory medicine; pediatrics; and molecular genetics and microbiology at the University of Florida in Gainesville. He is principal investigator for the National Institutes of Health-funded Type 1 Diabetes TrialNet Islet Cell Autoantibody Core Laboratory and Islet Autoantibody Standardization Program. Dr. Winter directs the endocrine autoantibody laboratory that at the University of Florida, has given numerous presentations and has published extensively on behalf of the AACC. A multiple-time winner of the AACC outstanding speaker award, Dr. Winter has served on several AACC annual meeting organizing committees. He is a fellow of the College of American Pathologists and the National Academy of Clinical Biochemistry, which he served as a member of the board of directors. He has contributed more than 200 articles, chapters, and abstracts. Lori J. Sokoll, Ph.D., FAACC is Professor of Pathology in the Johns Hopkins University School of Medicine and has secondary appointments in Oncology and Urology. She is Associate Director of the Clinical Chemistry Division and Director of the Special Chemistry Laboratory in the Johns Hopkins Hospital. Her research interests are focused on the evaluation and clinical applications of cancer biomarkers. She is an Associate Editor of the AACC publication Journal of Applied Laboratory Medicine.Lori J. Sokoll, Ph.D., FAACC is Professor of Pathology in the Johns Hopkins University School of Medicine and has secondary appointments in Oncology and Urology. She is Associate Director of the Clinical Chemistry Division and Director of the Special Chemistry Laboratory in the Johns Hopkins Hospital. Her research interests are focused on the evaluation and clinical applications of cancer biomarkers. She is an Associate Editor of the AACC publication Journal of Applied Laboratory Medicine. Dr Holmquist is board certified by the American Board of Clinical Chemistry, a fellow of the American Academy of Clinical Biochemistry, licensed by the state of California as a laboratory director, and certified as a New York State laboratory director. He earned his PhD in biochemistry and molecular biology from the University of California, Riverside. He has worked for more than 30 years in the life science industry, including more than 17 years in the diagnostic laboratory industry. He is a member of the Endocrine Society, the American Society for Mass Spectrometry and the American Association of Clinical Chemistry. Roger L. Bertholf, PhD, is Medical Director of Clinical Chemistry at Houston Methodist Hospital, and Professor of Clinical Pathology and Laboratory Medicine at Weill Cornell Medical College. He has served as president of the Association of Clinical Scientists and the Academy of the American Association for Clinical Chemistry, and chaired the Florida Board of Clinical Laboratory Personnel. He received the Young Clinical Scientist Award, Clinical Scientist of the Year Award, and Diploma of Honor from the Association of Clinical Scientists, and the President’s Award from the American Society for Clinical Pathology. Bertholf is Editor in Chief of Laboratory Medicine.Roger L. Bertholf, PhD, is Medical Director of Clinical Chemistry at Houston Methodist Hospital, and Professor of Clinical Pathology and Laboratory Medicine at Weill Cornell Medical College. He has served as president of the Association of Clinical Scientists and the Academy of the American Association for Clinical Chemistry, and chaired the Florida Board of Clinical Laboratory Personnel. He received the Young Clinical Scientist Award, Clinical Scientist of the Year Award, and Diploma of Honor from the Association of Clinical Scientists, and the President’s Award from the American Society for Clinical Pathology. Bertholf is Editor in Chief of Laboratory Medicine.