About the Book
The Third Edition of the Cytokine Handbook provides encyclopaedic coverage of the hemopoietic growth factors and the interleukin and interferon families of molecules, cytokine by cytokine. This new edition is completely revised to bring the reader the most up-to-date information on all of the important cytokines and cytokine receptors with the inclusion of new members of the interleukin family (up to IL-18), in depth treatment of cytokine receptors, as well as individual chapters on stem cell factor and flt3 ligand, gene therapy, and the chemokines. The Cytokine Handbook explains in detail the immunology and molecular biology of these molecules and their receptors, and discusses in additional chapters their therapeutic potential, assay systems, and phylogeny. It is written in an easy-to-follow style and includes an extensive bibliography. This book is a must for the library of any researcher or clinician interested in, or bewildered by, the diversity of cytokines.
Features: * Up-to-date material includes new members of the interleukin family (up to IL-18) * In-depth treatment of cytokine receptors * Individual chapters on stem cell factor and flt3 ligand, gene therapy, and the chemokines
Table of Contents:
The cytokines - an overview, I. Vilcek; Molecular genetics of cytokines, G.W. Duff; Interleukin-1, C.A. Dinarello; Interleukin-2 and interleukin-2 receptor, S.L. Gaffen et al; Interleukin-3, J.W. Schrader; Interleukin-4, P. Chomarat et al; Interleukin-5, C.J. Sanderson; Interleukin-6, T. Hirano; Interleukin-7, M.J. Maeurer et al; Interleukin-8 and other CXC chemokines, A. Wuyts et al; Interleukin-9, J.C. Renauld, J. Van Snick; Interleukin-10, R. de Waal Malefyt, K. Moore; Interleukin-11, S.E. Jacobsen; Interleukin-12, W. Storkus; Interleukin-13, E. de Waal Malefyt, J.E. de Vries; Interleukin-15, M.K. Kennedy et al; Interleukin-16,-17 and -18, M.A. Antonysamy et al; Interferons, E. De Maeyer, J. Maeyer-Guinard; Tumour necrosis factor, M. Zhang, K.J. Tracey; Tumour necrosis factor-related ligands and receptors, C.F. Ware et al; The biological complexity of transforming growth factor Beta and its receptors, Derynk, L. Choy; Granulocyte-macrophage colony stimulating factor, V.F.J. Quesniaux, T.C. Jones; Granulocyte colony stimulating factor, H. Murkami, S. Nagata; The biochemistry of CSF-1 action, J.A. Hamilton; Stem cell factor, G. Molineux, I.K. McNiece; Flt3 ligand, S.D. Lyman et al; The expanding universe of C1cx3 C, and C-C chemokines, K.B. Bacon et al; Cytokines and anti-cytokines therapy, C. Haworth et al; Clinical applications of haematopoietic growth factors, R.S. Negrin; Cytokine gene therapy, I.D. Davis, M.T. Lotze; Assays for cytokines, M. Wadhwa, R. Thorpe; Cytokines and their receptors as potential therapeutic targets, R. Geoffrey et al; The phylogeny of cytokines, C.J. Secombes.
Review :
Praise for the Previous Editions: "The Cytokine Handbook has brought together a number of internationally recognized scientists to detail and synthesize a wealth of information on cytokine biology in a much needed and most readable and highly referenced book." --Immunology Today "The Cytokine Handbook provides a comprehensive introduction to these cell-modulating proteins, with contents that are of interest not only to the uninitiated but also to those who are already hooked." --Nature "Provides an excellent foundation and will be a useful reference for biotechnology workers and investigators who desire a concise description of individual cytokines." --Biopharm
