About the Book
The Cytokine Reference is the most complete work for anyone interested in the role of cytokines in host defense processes. With essential and comprehensive information on all known cytokines, including chemokines, growth factors and neuropeptides, the database will include hundreds of entries with detailed descriptions of cytokine genes, proteins, cell sources, activities, receptors, receptor signal transduction, gene activation, pathophysiology, therapeutics and techniques. This encyclopedic reference is written by a panel of global experts and will include extensive tables and diagrams. This book/online bundle consists of a two-volume print set, plus a regularly updated and searchable Online Database.
Cytokines are produced by virtually all the cells in our bodies, and they regulate the systems that defend us against infection, tumors, and trauma. This publication and database will enable all those working in the field to find the information they need about this ever-expanding field.
Table of Contents:
Preface.
Dedication.
Contributors.
Volume I:
Overview:
Introduction to the Role of Cytokines in Innate Host Defense and Adaptive Immunity, J.J. Oppenheim and M. Feldmann.
Cytokine-Receptor Signaling at the Structural Level, R.M. Stroud, S. LaPorte and J.A. Wells.
Cytokines and Disease, M. Feldmann and F.M. Brennan.
Cytokine Assays, D.G. Remick and T.L. Whiteside.
Cytokine Standardization, R.C. Thorpe, A.R. Mire-Sluis and M. Wadhwa.
The Immunomodulating Interleukins:
Cytokines and the Immune System, S.K. Durum
TH1/TH2 Interleukins, S. Romagnani.
IL-2, K.A. Smith.
IL-4, A.D. Keegan.
IL-7, H. Spits.
IL-9, J.-C. Renauld.
IL-10, R. de Waal Malefyt.
IL-12, C. Esche, M.R. Shurin and M.T. Lotze.
IL-13, A.N.J. McKenzie and D.J. Matthews.
IL-15, T.A. Waldmann and Y. Tagaya.
IL-16, D.M. Center, H. Kornfeld and W.W. Cruikshank.
IL-17, S. Lebecque, F. Fossiez and E. Bates.
Growth Hormone, S. Chappel and W. Murphy.
Prolactin, H. Rui.
Parapox (Orf Virus) IL-10 Homolog, G. McFadden and R. Moyer.
The IL-1 Family:
Proinflammatory Cytokines, M. Feldmann and J. Saklatvala.
IL-1-alpha, C.A. Dinarello.
IL-1Ra, D. Burger and J.-M. Dayer.
IL-18, H. Okamura, H. Tsutsui, S.-i. Kashiwamura, T. Yoshimoto and K. Nakanishi.
IL-1-beta, C.A. Dinarello.
The TNF Family:
TNF Ligand and TNF/NGF Receptor Families, D. Wallach.
TNFalpha, B.B. Aggarwal, A. Samanta and M. Feldmann.
Lymphotoxin alpha and beta, N. Ruddle and C.F. Ware.
Fas Ligand, S. Nagata.
CD40 Ligand, E.A. Clark.
CD30 Ligand, P. Romagnani, C. Mavilia and S. Romagnani.
CD27 Ligand, W.A.M. Loenen.
TWEAK, J.L. Browning, C. Ambrose and C. Hession.
RANK Ligand, W.J. Boyle.
APRIL, J. Tschopp.
Apo2L/TRAIL, A. Ashkenazi.
LIGHT, C.F. Ware.
The IL-6 Family:
IL-6 Ligand and Receptor Family, T. Hirano and T. Fukada.
IL-6, T. Matsuda and T. Hirano.
IL-11, J.C. Keith Jr..
Oncostatin M, A.G. Bruce and T.M. Rose.
CT-1, K.R. Chien.
Chronic Inflammatory Mediators:
Cytokines Engaged in Antiviral Action, Macrophage Activation, Angiogenesis, and Regulation of Cell Growth and Differentiation, J. Vilcek.
IFNalpha, IFN beta, and IFNomega Ligands, M.S. Kunzi and P.P. Rowe.
IFNgamma, A.B. and K. Vandenbroeck.
Osteopontin, G.J. Nau.
MIF, C.N. Metz and R. Bucala.
Growth and Angiogenic Factors:
TGF beta, K.C. Flanders and A.B. Roberts.
BMP Family, A.H. Reddi and D. Haudenschild.
PDGF, E.W. Raines.
VEGF, N. Ferrara.
Poxvirus Vascular Endothelial Growth Factor (VEGF) Homologs of Orf Virus, G. McFadden and R. Moyer.
Angiostatin, A.E. Papathanassiu, S.J. Green, D.K. Grella and B.K.L. Sim.
Activin, T.K. Woodruff.
Endostatin, A.E. Papathanassiu, S.J. Green, D.K. Grella and B.K.L. Sim.
Methoxyestradiol, A.E. Papathanassiu, S.J. Green, D.K. Grella and B.K.L. Sim.
Poxvirus Growth Factors Related to EGF, G. McFadden and R. Moyer.
Hematopoietic Factors:
Hematopoietic Growth Factors, N.A. Nicola.
IL-3, J.W. Schrader.
IL-5, G.T.F. Schwenger, V.A. Mordvinov, R. Fournier, P. Czabotar, S. Peroni and C.J. Sanderson.
Stem Cell Factor, J.R. Keller and D.M. Linnekin.
GM-CSF, N.A. Nicola.
CSF-1, E.R. Stanley.
G-CSF, S. Nagata.
Erythropoietin, J.L. Spivak.
Thrombopoietin, D.J. Kuter.
CXC Chemokines:
Chemotactic Factors, Neuropeptides, and Other Ligands for Seven Transmembrane Receptors, J.J. Oppenheim, O.M.Z. Howard and E. Goetzl.
MGSA/GRO, D. Wang and A. Richmond.
ENA-78, A. Walz.
IL-8, H. Iizasa and K. Matsushima.
GCP-2, A. Wuyts, P. Proost and J. Van Damme.
CTAP-III, betaTG, and NAP-2, E. Brandt, A. Ludwig and H.-D. Flad.
Platelet Factor 4, G. Neufeld, G. Akiri and Z. Vadasz.
IP-10, A.D. Luster.
MIG, J.M. Farber.
SDF-1, C.R. Mackay.
BLR1 Ligand/BCA-1/BLC, R. Förster.
9E3/cCAF, M. Martins-Green.
CC, C, and CX3C CHEMOKINES:
MCP-1, MCP-2, MCP-3, MCP-4, and MCP-5, B.J. Rollins.
RANTES, T.J. Schall and D.R. Greaves.
I-309, M.S. Krangel.
MIP-alpha, MIP-beta, B. Sherry and G. Franchin.
Eotaxin, T.J. Williams and I. Sabore.
PARC, H. Nomiyama and O. Yoshie.
Eotaxin 2, J.R. White.
MIP-gamma/MRP-2, B.-S. Youn and B.S. Kwon.
Mu C10, B.-S. Youn and B.S. Kwon.
Leukotactin 1, B.-S. Youn and B.S. Kwon.
CKbeta8-, B.-S. Youn and B.S. Kwon.
HCC-1, T.W. Salcedo.
SLC (6CKine), H. Nomiyama and O. Yoshie.
ELC, H. Nomiyama and O. Yoshie.
TECK/CCL25, D.J. Catron and A. Zlotnik.
CC Chemokine of Molluscum Contagiosum Virus, G. McFadden and R. Moyer.
Lymphotactin, D.J. Catron and A. Zlotnik.
Fractalkine, D.R. Greaves and T.J. Schall.
TARC, O. Yoshie.
Poxvirus Secreted Complement Control Proteins, G. McFadden and R. Moyer.
Related Proinflammatory Factors:
fMLP, F. Boulay, M.-J. Rabiet and M. Tardif.
Lipoxin, B.D. Levy, C.B. Clish, K. Gronert and C.N. Serhan.
Platelet-Activating Factor, P.M. Henson.
Defensins, T. Ganz.
Leukotriene B4, B.K. Lam and K.F. Austen
Neuropeptides and Hormones:
Endorphins, F.S. Galin and J.E. Blalock.
alpha-MSH, J.M. Lipton.
VIP and PACAP, E.J. Goetzl, J.K. Voice and G. Dorsam.
Lysophospholipid Growth Factors, E.J. Goetzl, H. Lee and G.J. Tigyi.
ACTH, D.A. Weigent and J.E. Blalock.
SERP-1, a Secreted Poxviral Serpin, G. McFadden and R. Moyer.
Vaccinia Virus Semaphorin, G. McFadden and R. Moyer.
Volume II:
Immunomodulating Interleukin Receptors:
IL-2 Family Cytokines and their Receptors, W.J. Leonard.
IL-2 Receptor, K.A. Smith.
IL-4 Receptor, A.D. Keegan.
IL-7 Receptor, H. Spits.
IL-9 Receptor, J.-C. Renauld.
IL-10 Receptor, R. de Waal Malefyt.
IL-12 Receptor, C. Esche, M.R. Shurin and M.T. Lotze.
IL-13 Receptor, D.J. Matthews and A.N.J. McKenzie.
IL-15 Receptor, T.A. Waldmann and Y. Tagaya.
IL-16 Receptor (CD4), D.M. Center, H. Kornfeld and W.W. Cruikshank.
IL-17 Receptor, S. Lebecque, F. Fossiez and E. Bates.
Prolactin Receptor, V. Goffin and P.A. Kelly.
IL-1 Family Receptors:
IL-1 Receptor Family, L.A.J. O'Neill and S.K. Dower.
IL-1 Receptor Type I, C.A. Dinarello.
Poxvirus IL-1beta Receptor Homologs, G. McFadden and R. Moyer.
IL-18 Receptor, H. Okamura, H. Tsutsui, S.-i. Kashiwamura, T. Yoshimoto and K. Nakanishi.
IL-1 Receptor Type II, C.A. Dinarello.
TNF Family Receptors:
TNF Receptors, B.B. Aggarwal, A. Samanta and M. Feldmann.
Poxvirus TNF Receptor Homologs, G. McFadden and R. Moyer.
Lymphotoxin beta Receptor, N. Ruddle and C.F. Ware.
Fas, S. Nagata.
CD40, E.A. Clark.
CD30, F. Annunziato, P. Romagnani, C. Mavilia, G. Pizzolo, H. Stein and S. Romagnani.
4-1BB, D.S. Vinay and B.S. Kwon.
RANK, W.J. Boyle.
Osteoprotegerin, W.J. Boyle.
CD27, W.A.M. Loenen.
HVEM, C.F. Ware.
DR4, DR5, DcR1, DcR2, A. Ashkenazi.
DcR3, A. Ashkenazi.
Ox40, D.S. Vinay and B.S. Kwon.
GIT Receptor, D.S. Vinay and B.S. Kwon.
IL-6 Family Receptors:
IL-6 Receptor, M. Hibi and T. Hirano.
IL-11 Receptor, J. Keith.
OSM Receptor, T.M. Rose and A.G. Bruce.
CT-1 Receptor, K.R. Chien.
Receptors for Chronic Inflammatory Mediators:
IFNgamma Receptor, V. Shankaran and R.D. Schreiber.
Poxvirus IFNgamma Receptor Homologs, G. McFadden and R. Moyer.
IFN c beta Receptor, S.J. Haque and B.R.G. Williams.
Poxvirus IFN c beta Receptor Homologs, G. McFadden and R. Moyer.
Osteopontin Receptor, G.J. Nau.
TGF beta Receptors, P. ten Dijke and C.-H. Heldin.
BMP Receptor, A.H. Reddi.
Hematopoietic Receptors:.
Hematopoietic Receptor Family, A. Miyajima.
IL-3 Receptor, J.W. Schrader.
IL-5 Receptor, C.J. Bagley, J. Tavernier, J.M. Woodcock and A.F. Lopez.
SCF Receptor, D. Linnekin and J.R. Keller.
GM-CSF Receptor, N.A. Nicola.
G-CSF Receptor, S. Nagata.
TPO Receptor, D.J. Kuter and J. Li.
CXC Chemokine Receptors:
Chemokine Receptors: Overview, P.M. Murphy.
CXCR1 and CXCR2, I. Roth and C. Hebert.
CXCR3, J.M. Farber and B. Moser.
CXCR4, B. Moser.
CXCR5, R. Föester.
CC, C, and CX3C CHEMOKINE RECEPTORS:
CCR1, R. Horuk.
CCR2, J.M. Rodriguez-Frade, M. Mellado and C. Martinez-A.
CCR3, C.R. Mackay.
CCR4, C.A. Power.
CCR5, C. Blanpain and M. Parmentier.
CCR6, J.M. Farber.
CCR7, H. Namiyama and O. Yoshie.
CCR8, M. Napolitano and A. Santoni.
D6, G. Graham and R. Nibbs.
ECRF3, S.K. Ahuja.
Poxvirus Membrane-bound G Protein-coupled Receptor Homologs, G. McFadden and R. Moyer.
US28, J.-L. Gao.
Kaposi's Sarcoma-associated Herpesvirus GPCR, E. Geras-Raaka and M.C. Gershengorn.
DARC, R. Horuk.
CX3CR1, T. Imai and O. Yoshie.
Poxvirus Secreted Chemokine-binding Proteins, G. McFadden and R. Moyer.
CCR9, A. Zaballos, J. Gutiérrez, R. Varona and G. Márquez.
XCR1, O. Yoshie.
Miscellaneous Proinflammatory Factor Receptor:
C5a Receptor, T.E. Hugli and J.A. Ember.
C3a Receptor, J.A. Ember and T.E. Hugli.
PAF Receptors, P.M. Henson.
fMLP Receptors, F. Boulay, M.-J. Rabiet and M. Tardif.
Opioid mu, delta, and kappaReceptors for Endorphins, D.J.J. Carr and J.E. Blalock.
Lipoxin A4 Receptor, N. Chiang, K. Gronert, F.-H. Que and C.N. Serhan.
ACTH Receptor, F.S. Galin and J.E. Blalock
BLTR: the Leukotriene B4 Receptor, A.D. Luster and A.M. Tager.
PACAP and VIP Receptors, E.J. Goetzl, J.K. Voice and G. Dorsam.
Lysophospholipid Growth Factor Receptors, E.J. Goetzl, S. An and H. Lee.
Appendix.
Abbreviations.
List of Suppliers.
Index.
