Reproduction of Eukaryotic Cells

Reproduction of Eukaryotic Cells organizes in a single source the principal facts and observations on the cell life cycle and reproduction of eukaryotic cells. The aim is to increase the overall understanding of how these cells reproduce themselves and how this reproduction is regulated. The book begins with a discussion of the sections of the cell cycle and regulation of cell reproduction. Separate chapters on cell growth, cell synchrony, the G1 period, S period, and G2 period follow. Subsequent chapters are devoted to activities during cell division; cell cycle changes in surface morphology; the role of cyclic AMP (cAMP) and cyclic GMP (cGMP) in regulation of cell reproduction; and changes in nuclear proteins, RNA synthesis, and enzyme activities during the cell cycle. The final chapter covers the genetic analysis of the cell cycle.

Table of Contents:
Preface1 Introduction Sections of the Cell Cycle Regulation of Cell Reproduction 2 Cell Growth through the Cycle Fission Yeast (Schizosaccharomyces pombe) Amoeba proteus Tetrahymena pyriformis Mouse Fibroblast Conclusions 3 Cell Synchrony Natural Synchrony Experimentally Derived Synchrony 4 The G1 Period Variableness of G1 Relation of Cell Growth to the Length of G1 Control of Cell Reproduction in G1 Requirements for Protein and RNA Synthesis to Complete G1 Preparation for DNA Synthesis 5 Initiation of the S Period Role of Nuclear-Cytoplasmic Interactions in DNA Synthesis Intranuclear Site of Initiation and Continuation of DNA Synthesis 6 The S Period The Number of Replicating Units (Replicons) Minimum Number of Replicon Families Apparent Change in the Number of Origins of Replication in Relation to Development The Ordering of DNA Replication Requirements for Protein and RNA Synthesis during the S Period The Length of the S Period in Cells of Different Ploidies 7 The G2 Period Preparation for Mitosis Arrest of the Cycle in G2 Requirements for Protein and RNA Syntheses during G2 The G2 to D Transition 8 Activities during Cell Division RNA Synthesis during Mitosis Protein Synthesis during Mitosis Reversible Shift of Nuclear RNA and Protein to the Cytoplasm during Mitosis 9 Cell Surface Changes during the Cycle Morphological Changes Chemical Changes of the Plasma Membrane Plant Lectin Binding and Cell Agglutinability 10 Cyclic AMP, Cyclic GMP, and Cell Reproduction cAMP and the Cell Cycle Effects of Experimentally Induced Increases in Intracellular cAMP on Cell Growth Cyclic Nucleotides and the Imposition and Release of G1 Arrest Regulation of cAMP Levels in Cells 11 Nuclear Proteins and the Cell Cycle Histones Nonhistone Nuclear Proteins 12 RNA Synthesis and the Cell Cycle Text 13 Patterns of Enzyme Activities through the Cell Cycle Text 14 The Genetics of the Cell Cycle How Much of the Genome Is Specifically Concerned with the Cell Cycle? Genetic Analysis of the Cell Cycle in Yeast Genetic Analysis of the Cell Cycle in Mammalian Cells The Concept of Regulatory Genes for Cell Reproduction Final Comment BibliographyIndex