Structure and Function of Plasma Proteins
Home > Medicine & Health Science textbooks > Pre-clinical medicine: basic sciences > Physiology > Structure and Function of Plasma Proteins
Structure and Function of Plasma Proteins

Structure and Function of Plasma Proteins

|
     0     
5
4
3
2
1




Out of Stock


Notify me when this book is in stock
About the Book

Table of Contents:
1 Ontogeny of Human Plasma Proteins: Detection of the Onset and Site of Synthesis Using Genetic Markers and in Vitro Cultures.- 1.1. Introduction.- 1.2. Immunoglobulins.- 1.2.1. Classes and Subclasses and Genetic Markers.- 1.2.2. Synthesis of Ig Molecules at Cellular Level.- 1.2.3. Transfer of Immunoglobulins through the Placenta.- 1.2.4. Synthesis of Immunoglobulins during Fetal Life.- 1.3. Complement.- 1.3.1. The Components of Complement.- 1.3.2. Levels and Fetal Synthesis of the Components of C.- 1.4. Haptoglobin System.- 1.5. Transferrins.- 1.6. ?-Lipoprotein Variants: The Ag and Lp Systems.- 1.7. Group-Specific Components: The Gc System.- 1.8. ?1-Antitrypsin: The Pi System.- 1.9. Ceruloplasmin.- 1.10. Other Adult Plasma Proteins.- 1.11. Fetal Proteins.- 1.12. ?-Fetoprotein (AFP).- 1.12.1. AFP in Patients with Primary Cancer of Liver and Teratoblastoma.- 1.12.2. Amniotic Levels of AFP in Neural Tube Defects, Fetal and Placental Distress.- 1.13. Carcinoembryonic Antigen.- 1.14. Fetal Sulfoglycoprotein Antigen (FSA).- 1.15. Other Fetal Proteins Associated with Cancer.- 1.16. Conclusion.- References.- 2 Transferrin.- 2.1. Introduction.- 2.2. Historical.- 2.3. Physicochemical Properties of Transferrin.- 2.3.1. Molecular Weight.- 2.3.2. Amino Acid Composition.- 2.3.3. Carbohydrate Composition.- 2.3.4. Structure of Transferrin.- 2.4. The Metal-Binding Sites.- 2.4.1. Structure of the Binding Sites: Ligands.- 2.4.2. Strength of Metal Binding to Transferrin.- 2.4.3. The Role of Anions in Metal-Transferrin Complexes.- 2.4.4. Differences between Metal-Binding Sites.- 2.4.5. The Effect of Iron-Binding on Transferrin.- 2.4.6. The Binding of Metals Other than Iron.- 2.5. Functions of Transferrin.- 2.5.1. Iron Exchange.- 2.5.2. Bacteriostasis.- 2.6. Distribution and Metabolism.- 2.6.1. Atransferrinemia.- 2.6.2. Transferrin Levels in Plasma and Serum.- 2.6.3. Transferrin in Other Body Fluids.- 2.6.4. Factors Affecting Transferrin Levels in Plasma.- 2.6.5. Distribution and Catabolism.- 2.6.6. Synthesis of Transferrin.- 2.7. Conclusion.- References.- 3 Albumin Synthesis and Degradation.- 3.1. Introduction.- 3.2. Evolution and Variants.- 3.3. Albumin Metabolism.- 3.3.1. Methods of Study.- 3.3.2. Albumin Synthesis.- 3.3.3. Site of Albumin Synthesis.- 3.4. Albumin Transport.- 3.4.1. Cellular Transport.- 3.4.2. Extracellular Transport.- 3.5. Development and Normal Values for Albumin Metabolism.- 3.5.1. Development.- 3.5.2. Albumin Metabolism.- 3.6. Nutritional Control.- 3.7. Hormonal Effects.- 3.8. Osmotic Regulation.- 3.9. Environmental Effects.- 3.9.1. Distribution-Intravascular.- 3.9.2. Distribution-Extravascular.- 3.10. Degradation.- Addendum.- References.- 4 Turnover of Plasma Proteins.- 4.1. Introduction.- 4.2. Measurement of Protein Turnover.- 4.2.1. Measurement of Synthesis Rates in Vivo.- 4.2.2. Measurement of Degradation Rates in Vivo.- 4.2.3. Measurement of Degradation and Synthesis in Nonsteady-State Conditions.- 4.2.4. Short-Term Measurement of Degradation.- 4.2.5. Measurement of Synthesis and Degradation in Vitro.- 4.3. Mechanisms of Synthesis and Degradation of Liver-Produced Plasma Proteins.- 4.3.1. Mechanisms of Synthesis at the Transcriptional Level.- 4.3.2. Mechanisms of Synthesis at the Translational Level.- 4.3.3. Mechanisms of Degradation of Plasma Proteins.- 4.4. Regulation of Protein Turnover.- 4.4.1. Nonspecific Regulatory Mechanisms.- 4.4.2. Specific Regulatory Mechanisms.- 4.5. Summary.- References.- 5 The Role of Sialic Acid in the Catabolism of Plasma Glycoproteins.- 5.1. Introduction.- 5.2. A Unified Mechanism for Turnover and Catabolism.- 5.2.1. Catabolic Initiation.- 5.2.2. Interaction of Desialylated Glycoproteins with Liver Cells.- 5.2.3. Catabolism.- 5.3. Physiological Significance of Desialylation of Plasma Glycoproteins.- 5.4. Disorders of Glycoprotein Catabolism.- References.- 6 Catabolism of Plasma Proteins.- 6.1. Introduction.- 6.2. Preparation of Labeled Proteins for Metabolic Studies.- 6.3. Some Considerations about Sites of Catabolism.- 6.3.1. The Plasma and Other Body Fluid Compartments.- 6.3.2. The Cell in General.- 6.3.3. The Gastrointestinal Lumen.- 6.4. Organs Involved in Plasma Protein Catabolism.- 6.4.1. The Liver.- 6.4.2. The Lung.- 6.4.3. The Kidney.- 6.4.4. The Reticuloendothelial Cells.- 6.5. Is the Catabolism of Plasma Proteins a One-Step Process?.- 6.6. Concluding Remarks.- References.- 7 Plasma Proteinase Inhibitors.- 7.1. Introduction.- 7.2. The Identification and Separation of Plasma Proteinase Inhibitors.- 7.3. ?1-Antichymotrypsin.- 7.4. ?1-Globulin Trypsin Inhibitor (?1-TI).- 7.4.1. Purification of ?1-TI.- 7.4.2. Measurement of Proteinase-Inhibitory Activity of ?1-TI..- 7.4.3. Normal Plasma Levels of ?1TI.- 7.4.4. The Interaction of ?1-TI with Proteinases.- 7.4.5. Metabolism and Turnover of ?1-TI.- 7.4.6. Variations of ?1-TI in Health and Disease.- 7.4.7. Genetic Polymorphism of ?1-TI.- 7.4.8. The Association of ?1-TI Deficiency with Chronic Obstructive Pulmonary Disease (COPD).- 7.4.9. ?1-TI Deficiency in Infantile Cirrhosis.- 7.4.10. ?1-TI Levels in the Idiopathic Respiratory Distress Syndrome (IRDS).- 7.5. ?2-Macroglobulin (?2-M).- 7.5.1. Purification and Properties.- 7.5.2. Measurement of ?2-M.- 7.5.3. Normal Levels of ?2-M.- 7.5.4. Variation of ?2-M Levels in Health and Disease.- 7.5.5. Metabolism and Turnover of ?2-M.- 7.5.6. Genetics of ?2-M.- 7.5.7. The Interaction of ?2-M with Proteinases.- 7.5.8. Residual Peptidase and Proteinase Activity of ?2-M-Proteinase Complexes.- 7.5.9. In Vivo Fate of ?2-M-Proteinase Complexes.- 7.6. Inter-?-Trypsin Inhibitor (I?I).- 7.7. Antithrombin III (AT III).- 7.8. Cl-Esterase Inhibitor (Cl INH).- 7.8.1. Measurement of Cl INH.- 7.8.2 Inhibition of Proteinases by Cl INH.- 7.8.3. Deficiencies of Cl INH.- 7.9. Concluding Remarks.- Addendum.- References.- 8 Growth Regulation in Vitro and the Role of Serum.- 8.1. Introduction.- 8.2. Contact Inhibition of Locomotion and Density-Dependent Inhibition of Growth.- 8.3. Density-Dependent Inhibition of Growth and Serum Requirement.- 8.4. Transformation and the Loss of Contact Inhibition of Locomotion.- 8.5. Transformation and Serum Requirement.- 8.6. Transformation and Density-Dependent Inhibition of Growth.- 8.7. Density-Dependent Inhibition of Growth: Some Conclusions.- 8.8. Anchorage Dependence and Sensitivity to Polyanions of Normal and Transformed Cells.- 8.9. Fractionation of Serum.- 8.9.1. Growth Factors.- 8.9.2. Migration Factors.- 8.9.3. Survival Factors.- 8.10. Physiological Action of Serum.- 8.11. Significance of Growth Regulation in Vitro.- References.- 9 Fractionation of Plasma Proteins.- 9.1. Introduction.- 9.2. Gel Chromatography.- 9.2.1. Outline of Principle.- 9.2.2. Gel Chromatography Media.- 9.2.3. Fractionation of Serum by Gel Chromatography.- 9.3. Ion Exchange Chromatography.- 9.3.1. Outline of Principle.- 9.3.2. Classification of Ion Exchangers.- 9.3.3. Elution Methods.- 9.3.4. Ion Exchange of Whole Serum.- 9.4. Affinity Chromatography.- 9.4.1. Definition and Brief History.- 9.4.2. Brief Outline of the Procedure.- 9.4.3. Matrix Materials.- 9.4.4. Affinity Materials (Ligands).- 9.4.5. Methods of Covalently Linking Ligand to Matrix.- 9.4.6. Preparation of Agarose Derivatives.- 9.5. Polyacrylamide Gel Electrophoresis.- 9.5.1. Gel Formation.- 9.5.2. Analytical-Scale Experiments.- 9.5.3. Radioactive Techniques and Polyacrylamide Gel Electrophoresis.- 9.5.4. Molecular-Weight Determinations Using Polyacrylamide Gel Electrophoresis.- 9.5.5. Combination of Polyacrylamide Gel Electrophoresis with Other Techniques.- 9.5.6. Preparative-Scale Polyacrylamide Gel Electrophoresis.- 9.6. Isoelectric Focusing or Electrofocusing.- 9.6.1. Principle of the Method.- 9.6.2. Properties of Ampholytes.- 9.6.3. Methods of Electrofocusing Using Natural pH Gradients.- 9.6.4. A Brief Outline of a Practical Experiment Using a Vertical Column.- 9.6.5. Electrofocusing in a Horizontal Apparatus Using an Entirely Liquid System. Zone Convection Electrofocusing.- 9.6.6. Separation of Ampholine from Proteins after Electrofocusing.- 9.6.7. Electrofocusing in Gels.- 9.6.8. Experimental Details for Electrofocusing in Polyacrylamide Gels.- 9.6.9. Electrofocusing in Layers of Sephadex.- 9.7. Two-Dimensional Immunoelectrophoresis (Laurell Technique).- 9.7.1. Principle.- 9.7.2. Identification of Proteins.- 9.7.3. Practical Details.- 9.7.4. Combination of Two-Dimensional Immunoelectrophoresis with Polyacrylamide Gel Electrophoresis or Electrofocusing.- 9.8. Isotachophoresis.- 9.8.1. Outline of Principle.- 9.8.2. Analytical-Scale Isotachophoresis.- 9.8.3. Preparative Isotachophoresis.- 9.9. Two-Phase Separation Systems.- 9.9.1. Aqueous Solvents.- 9.9.2. Distribution of a Protein between Two Phases.- 9.9.3. Countercurrent Separations.- 9.9.4. Distribution of a Protein between Two Phases in a Countercurrent Separator.- 9.9.5. Factors Affecting Resolution of Proteins.- 9.9.6. Removal of Polymers.- 9.9.7. Serum Proteins.- 9.10. Evidence of Denaturation.- Addendum.- References.- 10 Protein Chemistry in a General Hospital.- 10.1. Introduction.- 10.2. Methods of Protein Analysis-General Aspects.- 10.2.1. Measurement of Proteins.- 10.2.2. Quality Control and Standards.- 10.2.3. Preservation of Specimens.- 10.2.4. Factors Interfering with the Biochemical Analyses of Proteins.- 10.2.5. Physiological Variations in Plasma Protein Measurement.- 10.2.6. Normal Ranges.- 10.3. Chemical and Physical Methods for the Determination of Serum Proteins.- 10.3.1. Total Protein.- 10.3.2. Albumin.- 10.3.3. Serum Protein Electrophoresis.- 10.4. Immunochemical Methods for the Measurement and Examination of Serum Proteins.- 10.4.1. Simplified (Single) Radial Immunodiffusion.- 10.4.2. "Rocket" Electroimmunoassay for the Estimation of Serum Proteins.- 10.4.3. Two-Dimensional Immunoelectrophoresis.- 10.4.4. Nephelometric Techniques in Protein Chemistry.- 10.4.5. Radioimmunoassay Techniques.- 10.4.6. Special Techniques for Individual Proteins.- 10.5. Monoclonal Protein Increases.- 10.5.1. Serum Immunoelectrophoresis.- 10.5.2. Detection and Identification of Bence-Jones Proteinuria.- 10.5.3. An Immunoselection Technique to Identify Heavy Chain.- 10.5.4. Detection of 7 S IgM Subunits.- 10.5.5. Measurement of Serum Viscosity.- 10.6. Plasma Proteins and Disease.- 10.7. Hypogammaglobulinemia.- 10.8. Hypergammaglobulinemia.- 10.8.1. Polyclonal Hypergammaglobulinemia.- 10.8.2. Monoclonal Hypergammaglobulinemia.- 10.9. Renal Disease.- 10.10. Central Nervous System.- 10.11. Gastrointestinal Disease.- 10.12. Liver Disease.- 10.13. Respiratory Disease.- 10.14. Skin Disease.- 10.15. Cardiovascular Disease.- 10.16. Pediatrics.- 10.17. Cryoproteinemia.- 10.18. Protein Changes in Association with Neoplasia.- References.


Best Sellers


Product Details
  • ISBN-13: 9780306350825
  • Publisher: Springer Science+Business Media
  • Publisher Imprint: Kluwer Academic/Plenum Publishers
  • Language: English
  • ISBN-10: 0306350823
  • Publisher Date: 01 Sep 1976
  • Binding: Hardback
  • Returnable: N


Similar Products

Add Photo
Add Photo

Customer Reviews

REVIEWS      0     
Click Here To Be The First to Review this Product
Structure and Function of Plasma Proteins
Springer Science+Business Media -
Structure and Function of Plasma Proteins
Writing guidlines
We want to publish your review, so please:
  • keep your review on the product. Review's that defame author's character will be rejected.
  • Keep your review focused on the product.
  • Avoid writing about customer service. contact us instead if you have issue requiring immediate attention.
  • Refrain from mentioning competitors or the specific price you paid for the product.
  • Do not include any personally identifiable information, such as full names.

Structure and Function of Plasma Proteins

Required fields are marked with *

Review Title*
Review
    Add Photo Add up to 6 photos
    Would you recommend this product to a friend?
    Tag this Book Read more
    Does your review contain spoilers?
    What type of reader best describes you?
    I agree to the terms & conditions
    You may receive emails regarding this submission. Any emails will include the ability to opt-out of future communications.

    CUSTOMER RATINGS AND REVIEWS AND QUESTIONS AND ANSWERS TERMS OF USE

    These Terms of Use govern your conduct associated with the Customer Ratings and Reviews and/or Questions and Answers service offered by Bookswagon (the "CRR Service").


    By submitting any content to Bookswagon, you guarantee that:
    • You are the sole author and owner of the intellectual property rights in the content;
    • All "moral rights" that you may have in such content have been voluntarily waived by you;
    • All content that you post is accurate;
    • You are at least 13 years old;
    • Use of the content you supply does not violate these Terms of Use and will not cause injury to any person or entity.
    You further agree that you may not submit any content:
    • That is known by you to be false, inaccurate or misleading;
    • That infringes any third party's copyright, patent, trademark, trade secret or other proprietary rights or rights of publicity or privacy;
    • That violates any law, statute, ordinance or regulation (including, but not limited to, those governing, consumer protection, unfair competition, anti-discrimination or false advertising);
    • That is, or may reasonably be considered to be, defamatory, libelous, hateful, racially or religiously biased or offensive, unlawfully threatening or unlawfully harassing to any individual, partnership or corporation;
    • For which you were compensated or granted any consideration by any unapproved third party;
    • That includes any information that references other websites, addresses, email addresses, contact information or phone numbers;
    • That contains any computer viruses, worms or other potentially damaging computer programs or files.
    You agree to indemnify and hold Bookswagon (and its officers, directors, agents, subsidiaries, joint ventures, employees and third-party service providers, including but not limited to Bazaarvoice, Inc.), harmless from all claims, demands, and damages (actual and consequential) of every kind and nature, known and unknown including reasonable attorneys' fees, arising out of a breach of your representations and warranties set forth above, or your violation of any law or the rights of a third party.


    For any content that you submit, you grant Bookswagon a perpetual, irrevocable, royalty-free, transferable right and license to use, copy, modify, delete in its entirety, adapt, publish, translate, create derivative works from and/or sell, transfer, and/or distribute such content and/or incorporate such content into any form, medium or technology throughout the world without compensation to you. Additionally,  Bookswagon may transfer or share any personal information that you submit with its third-party service providers, including but not limited to Bazaarvoice, Inc. in accordance with  Privacy Policy


    All content that you submit may be used at Bookswagon's sole discretion. Bookswagon reserves the right to change, condense, withhold publication, remove or delete any content on Bookswagon's website that Bookswagon deems, in its sole discretion, to violate the content guidelines or any other provision of these Terms of Use.  Bookswagon does not guarantee that you will have any recourse through Bookswagon to edit or delete any content you have submitted. Ratings and written comments are generally posted within two to four business days. However, Bookswagon reserves the right to remove or to refuse to post any submission to the extent authorized by law. You acknowledge that you, not Bookswagon, are responsible for the contents of your submission. None of the content that you submit shall be subject to any obligation of confidence on the part of Bookswagon, its agents, subsidiaries, affiliates, partners or third party service providers (including but not limited to Bazaarvoice, Inc.)and their respective directors, officers and employees.

    Accept

    New Arrivals

    Inspired by your browsing history


    Your review has been submitted!

    You've already reviewed this product!