About the Book
Retinoic acid is of major importance in the regulation of normal gene expression in both embryonic and adult cells, through binding to, and activation of, specific retinoic acid receptors in the nucleus. Other nuclear receptors may bind to different retinoids. In the embryo, tissue and stage-specific distribution patterns of the different receptors, and of the cytoplasmic retinoid binding proteins, provide an underlying basis for the richly varied and changing
pattern of retinoid-related developmental gene expression. This book provides an up-to-date review of recent progress in understanding the roles of retinoids in both normal and abnormal differentiation, morphogenesis, and pattern formation. It includes molecular, cellular and embryonic approaches, which
are integrated wherever possible.
Table of Contents:
G. Morriss-Kay: Editorial Introduction; Part I: RETINOID RECEPTORS AND BINDING PROTEINS: Molecular Aspects: P. Leroy, A. Krust, P. Kastner, C. Mendelsohn, A. Zelent, & P. Chambon: Retinoic acid receptors; D.J. Mangelsdorf, & R.M. Evans: Vitamin A receptors: new insights on retinoid control of transcription; M. Pfahl, X-K. Zhang, J.M. Lehmann, M. Husmann, G. Graupner, & B. Hoffmann: Molecular mechanisms of retinoic acid action; C. Apfel, M. Crettaz, &
P. LeMotte: Differential binding and activation of synthetic retinoids to retinoic acid receptors; F. Chytil, D.G. Stump, R. ul Haq, M.G. Rush, & E.E. Mufson: Cellular retinol binding protein: regulation of expression and putative functions; Part II: RECEPTORS AND BINDING PROTEINS IN EMBRYOS: A. Rowe, N.S.C. Eager,
J.M. Richman, & P.M. Brickell: Retinoic acid receptors in the chick embryo; E. Ruberte, H. Nakshatri, P. Kastner, & P. Chambon: Retinoic acid receptors and binding proteins in mouse limb development; J. Brockes: Effect of retinoic acid on regenerating urodele limbs; M. Maden, E. Gale, C. Horton, & J.C. Smith: Retinoid binding proteins in the developing vertebrate nervous system; Part III: RETINOIDS AND DEVELOPING EPITHELIA; A.B. Roberts, A.B. Glick, & M.B. Sporn:
Interrelationships between two families of multifunctional effectors: retinoids and TGF-*B; D.R. Fitzpatrick, B.D. Abbott, & R.J. Akhurst: Palatal expression of TGF-*B isoforms in normal and retinoic acid-treated mouse embryos; G. Morriss-Kay, & R. Mahmood: Morphogenesis-related changes in extracellular matrix induced by retinoic
acid; M.H. Hardy: Diverse roles for retinoids in modifying skin, skin appendages, and oral mucosa in mammals and birds; J.P. Viallet, E. Ruberte, A. Krust, A. Zelent, & D. Dhouailly: Expression of retinoic acid receptors and dermal-epidermal interactions during mouse skin morphogenesis; Part IV: Retinoids in Gene Expression: E. Boncinelli, A. Simeone, D. Acampora, A. Faiella, M. D'Esposito, A. Stornaiuolo, M. Pannese, & A. Mallamaci: Differential regulation by retinoic acid of the
homeobox genes of the Hox family in human embryonal carcinoma cells; P. Murphy, G.M. Morriss-Kay, R.E. Hill, & D.R. Davidson: Retinoid-induced alterations of segmental organization and gene expression in the mouse hindbrain; J-C. Izpisúa-Belmonte, P. Dollé, C. Tickle, L. Wolpert, & D. Duboule: Hox-4 genes,
retinoic acid, and the specification of positional information during chick wing morphogenesis; P.J.A. Davies, J.P. Stein, E.A. Chiocca, J.P. Basilion, V. Gentile, V. Thomazy, & L. Fesus: Retinoid-regulated expression of transglutaminases: links to the biochemistry of programmed cell death; Part V: TERATOGENESIS OF 13-CIS-RETINOIC ACID: J. Creech Kraft: Pharmacokinetics, placental transfer, and teratogenicity of 13-cis-retinoic acid, its isomer and metabolites; E.J. Lammer, & D.L.
Armstrong: Malformations of hindbrain structures among humans exposed to isotretinoin (13-cis-retinoic acid) during early embryogenesis.
