Practical Transfusion Medicine

Practical Transfusion Medicine Practical Transfusion Medicine, Sixth Edition The pace of change in transfusion medicine is relentless, with new scientific and technological developments and continuing efforts to improve transfusion practice. This sixth edition of Practical Transfusion Medicine has been updated significantly to reflect the rapid changes in transfusion medicine since the fifth edition was published in 2017. The primary purpose of this edition remains the same as the first: to provide a comprehensive guide to transfusion medicine. This book contains more depth of information than standard handbooks on transfusion medicine, whilst being more concise and approachable than a standard reference text. This book covers the principles of transfusion medicine, the complications of transfusion, practice in blood centres and hospitals and clinical transfusion practice. This sixth edition includes a new section on patient blood management, cellular and tissue therapy, organ transplantation and the development of the evidence base for transfusion. It also features a new chapter on transfusion-associated circulatory overload to underline its importance as a complication of transfusion, and a reconfiguration of the section on clinical transfusion practice to allow consideration of the transfusion management of medical, surgical and haematology patients with and without bleeding. This sixth edition of Practical Transfusion Medicine provides accessible and comprehensive coverage of the field of transfusion medicine. It is a standalone text that will be useful to clinical and scientific staff: not only for trainees who require an overview of the field, but also for established practitioners who are involved in some aspect of transfusion medicine and require a comprehensive, accessible reference book.

Table of Contents:
List of Contributors ix Preface to the Sixth Edition xvi 1 Introduction: Two Centuries of Progress in Transfusion Medicine 1 Walter H. (Sunny) Dzik and Michael F. Murphy Part I Basic Principles of Immunohaematology 11 2 Essential Immunology for Transfusion Medicine 11 Gregory A. Denomme 3 Human Blood Group Systems 21 Geoff Daniels and Sean Stowell 4 Human Leukocyte Antigens 33 H. Cliff Sullivan and Caroline R. Alquist 5 Platelet and Neutrophil Antigens 47 Brian R. Curtis 6 Pretransfusion Testing and the Selection of Red Cell Products for Transfusion 64 Mark H. Yazer, Meghan Delaney and Gregory A. Denomme Copyrighted Material Part II Complications of Transfusions 77 7 Investigation of Acute Transfusion Reactions 77 Heather Leary, Kathryn E. Webert and Nancy M. Heddle 8 Haemolytic Transfusion Reactions 91 Edwin J. Massey, Robertson D. Davenport and Richard M. Kaufman 9 Febrile and Allergic Transfusion Reactions 108 Sarah K. Harm and Mark K. Fung 10 Transfusion- Associated Circulatory Overload 120 Robert B. Klanderman and Alexander P.J. Vlaar 11 Transfusion- Related Acute Lung Injury (TRALI) 130 Alexander P.J. Vlaar and Rick Kapur 12 Purported Adverse Effects of ‘Old Blood’ 145 Lirong Qu and Darrell J. Triulzi 13 Transfusion- Induced Immunomodulation 154 Neil Blumberg, Majed A. Refaai and Joanna M. Heal 14 Transfusion- Associated Graft- versus- Host Disease and Microchimerism 166 Alexandra Budhai, Richard O. Francis and Beth H. Shaz 15 Posttransfusion Purpura 181 Michael F. Murphy 16 Heparin- Induced Thrombocytopenia 187 Theodore E. Warkentin and Andreas Greinacher 17 Transfusion- Transmitted Infections 206 Steven J. Drews and Roger Y. Dodd 18 Bacterial Contamination 221 Sandra Ramírez- Arcos and Mindy Goldman 19 Emerging Infections and Transfusion Safety 229 Roger Y. Dodd Part III Practice in Blood Centres and Hospitals 238 20 Regulatory Aspects of Blood Transfusion 238 Louis M. Katz, Peter Flanagan and William G. Murphy 21 The Role of Hemovigilance in Transfusion Safety 247 Katharine A. Downes and Barbee I. Whitaker 22 Donors and Blood Collection 257 Marc Germain and Pierre Tiberghien 23 Blood Donation Testing and the Safety of the Blood Supply 269 Mindy Goldman and Steven J. Drews 24 Production and Storage of Blood Components 278 Marissa Li, Rebecca Cardigan, Stephen Thomas and Ralph Vassallo 25 Blood Transfusion in Hospitals 290 Zoe K. McQuilten, Erica M. Wood, Mark H. Yazer and Michael F. Murphy 26 Disaster Preparedness 313 Heidi Doughty, Fateha Chowdhury and Richard Rackham 27 Blood Transfusion in a Global Context 324 David J. Roberts, Imelda Bates, Stephen P. Field, Aggrey Dhabangi, Jean Pierre Allain and Meghan Delaney Part IV Clinical Transfusion Practice 337 28 Inherited and Acquired Disorders of Haemostasis 337 Irina Chibisov, Jansen Seheult and Franklin Bontempo 29 Point- of- Care Haemostasis Testing 353 Katrina M. Morgan, Matthew D. Neal, Louis Alarcon and Christine M. Leeper 30 Transfusion in Bleeding Patients 365 Aaron S. Hess, Lynn G. Stansbury and John R. Hess 31 Transfusion in Non- Bleeding Medical and Surgical Patients 374 Killian Donovan, Akshay Shah, Stuart McKechnie and Simon J. Stanworth 32 Transfusion in Malignant Haematological Disease 385 Lise J. Estcourt and Michael F. Murphy 33 Transfusion in Benign Haematological Disease 399 Eric Salazar and Christopher A. Tormey 34 Transfusion in Patients with Haemoglobinopathies 409 Yvette C. Tanhehco and Patricia A. Shi 35 Transfusing Neonates and Infants 417 Marianne E. Yee and Cassandra D. Josephson 36 Immunodeficiency and Immunoglobulin Therapy 426 Siraj A. Misbah Part V Patient Blood Management 441 37 Development of a Patient Blood Management Programme 441 Jonathan H. Waters 38 Perioperative Patient Blood Management 451 Martin Shao Foong Chong, Martin Rooms, Ravishankar Rao Baikady and Toby Richards 39 Restrictive Transfusion Practice and How to Implement It 465 Marie A. Hollenhorst and Lawrence Tim Goodnough 40 Using Data to Support Patient Blood Management 476 Nadia B. Hensley, Sandaruwani Abeysiri and Steven M. Frank Part VI Cellular Therapy and Transplantation 489 41 Regulation and Accreditation in Cellular Therapy 489 Julia Wolf, Zbigniew (Ziggy) M. Szczepiorkowski and James Griffin 42 Stem Cell Collection and Therapeutic Apheresis 504 Khaled El- Ghariani and Zbigniew (Ziggy) M. Szczepiorkowski 43 Haemopoietic Stem Cell Processing and Storage 519 Akash Gupta and Ronan Foley 44 Haematopoietic Cell Transplantation 531 Richard Salisbury, Yisu Gu, Rachael Hough and Robert D. Danby 45 CAR- T Cells and Recent Advances in Clinical Cellular Immunotherapy 543 Yisu Gu, Alex Rampotas, Connor Sweeney, David J. Roberts and Ronjon Chakraverty 46 Tissue Banking 554 Akila Chandrasekar, Richard Lomas and Paul Rooney Part VII Development of the Evidence Base for Transfusion 561 47 Observational and Interventional Trials in Transfusion Medicine 561 Alan T. Tinmouth, Dean Fergusson and Paul C. Hébert 48 Getting the Most Out of the Evidence for Transfusion Medicine and Lessons from the COVID- 19 Pandemic 576 Simon J. Stanworth, Susan J. Brunskill, Carolyn Dorée and Yulia Lin 49 A Primer on Biostatistics 590 Andrew W. Shih, Na Li, Celina Montemayor and Nancy M. Heddle 50 A Primer on Health Economics 609 Seema Kacker and Aaron A. R. Tobian 51 Scanning the Future of Transfusion Medicine 620 Jay E. Menitove, Paul M. Ness, Suzanne R. Thibodeaux and Edward L. Snyder Index 632