Molecular Structure: Chemical Reactivity and Biological Activity

This volume is based on a symposium held in Beijing in September 1986 and draws together the disciplines of chemistry, biology, physics and mineralogy and both practical and theoretical research to examine the question of structure. Structure can be characterized in many ways from simple structural formulae to complex wave functions depending on the discipline and area of application. The correlation between structure and chemical, physical or biological activity is often the main point of interest between diverse disciplines. The interdisciplinary nature of this study may appeal to scien tists.

Table of Contents:
Including crystallographic studies of hormones, drugs and antibiotics, steroidal neuromuscular blocking agents - chandonium, NMR analysis of conformation-activity in synthetic muscle relaxing agents, molecular mechanics, conformation of fentanyl and peptides and tobacco cembranoids and antifolate drugs, X-ray structure of rhomopsin A, aminoacids, structure-activity in fusicoccin and in nitroheterocyclic drugs, cinnamamides, QSAR and molecular modelling of 1 ,4-dihydropyridines, molecular model for the large ribosome particle, dehydrogenase binding by TAD, antifolate drugs, structure-function of elastase receptor + substrate interactions, nucleic acid junctions, kinked model of a DNA tridecamer with unpaired adenosine, carcinogens, methylated benz[a]anthracenes, antitumor anthracyclines, anticancer agents, hydrocarbon atoms from "Ab initio" SCF dimer calculations, organic chemistry, stereochemistry of bistricyclic ethylenes, bent bonds in polycyclic compounds, structure of unsaturated 8-membered carbocycles and of the inclusion properties of a novel coordinatoclathrate host and of the tetrahedral intermediate in the carboxypeptidase A mechanism and of cytochrome P-450 enzyme inhibitors, interactions in cyclodextrin clathrates - pheromones, host-guest interactions in b-cyclodextrin inclusion complexes with some benzene derivatives having hydrophilic and/or hydrophobic side chains, Werner clathrates, chirality, rate of b-isomerization of the cobaloxime complex, structure of organic, organoelement and organometallic compounds and organometallic catalysts and ligand, trinuclear molybdenum clusters, building chains and clusters for metal carbynes, diphosphinomethane-bridged diplatinum complexes, phase transitions in l-Co(sepulchrate)(NO3)3, gas-phase UV-photoelectron spectra and DV-Xa calculations of H2-XO (X=C, N) bridged binuclear complexes, cluster dynamics, structural hierarchy for oxy-salt minerals, X-ray and xoom crystallography, molecular graphics, penicillin.