Handbook of Mitochondrial Dysfunction

Mitochondria produce the chemical energy necessary for eukaryotic cell functions; hence mitochondria are an essential component of health, playing roles in both disease and aging. More than 80 human diseases and syndromes are associated with mitochondrial dysfunction; this book focuses upon diseases linked to these ubiquitous organelles. Accumulation of mitochondrial DNA damage results in mitochondrial dysfunction through two main pathways. Mutation in mitochondrial DNA causes diseases such as Kearns-Sayre syndrome and Pearson syndrome. Mutation in chromosomal DNA causes diseases such as Parkinson's disease and schizophrenia. These and many other diseases are reviewed in this book. Key Features Presents the detailed structure of mitochondria, mitochondrial function, roles of oxidants and antioxidants in mitochondrial dysfunction. Includes summary of both causes and effects of these diseases. Discusses current and potential future therapies for mitochondrial dysfunction diseases Explores a wide variety of diseases caused by dysfunctional mitochondria.

Table of Contents:
Contents Preface ........................................................................................................................................................................... xi Acknowledgment......................................................................................................................................................... xiii About the Editor .......................................................................................................................................................... xv Contributors ............................................................................................................................................................... xvii SECTION I Introduction: Structure and Function of Mitochondria Chapter 1 Mitochondrial Structure and Function ....................................................................................................... 3 Marcos Roberto de Oliveira Chapter 2 Structure, Function and Evolutionary Aspects of Mitochondria ................................................................ 9 Puja Agarwal, Mehali Mitra, and Sujit Roy Chapter 3 Mitochondrial Genome Damage, Dysfunction and Repair ........................................................................23 Kalyan Mahapatra, Sayanti De, and Sujit Roy SECTION II Mitochondrial Dysfunction and Diseases Chapter 4 Instability of Human Mitochondrial DNA, Nuclear Genes and Diseases ..................................................39 Katarzyna Tońska Chapter 5 Kearns-Sayre Syndrome .............................................................................................................................55 Josef Finsterer Chapter 6 Mitochondrial Dysfunction and Barth Syndrome......................................................................................61 Arianna F. Anzmann, Steven M. Claypool, and Hilary Vernon Chapter 7 Mitochondrial Dysfunction in the Pathophysiology of Alzheimer’s Disease ..............................................79 Isaac G. Onyango Chapter 8 Mitochondrial Dysfunction in Multiple Sclerosis.......................................................................................87 Angela Dziedzic, Elzbieta Miller, Joanna Saluk-Bijak, and Michał Bijak Chapter 9 Mitochondrial Dysfunction in Chronic Kidney Disease.............................................................................93 Maria V. Irazabal and Alfonso Eirin Chapter 10 Mitochondrial Dysfunction in Breast Cancer: A Potential Target from the Bench to Clinical Therapeutics.............................................................................................................................................103 Thalita Basso Scandolara, Letícia Madureira Pacholak, Thayse Fachin Cormanique, Rodrigo Kern, and Carolina Panis Chapter 11 Mitochondrial Dysfunction and DNA Methylation in Atherosclerosis ....................................................115 Silvio Zaina and Gertrud Lund Chapter 12 Mitochondrial Dysfunction and Heart Diseases ......................................................................................127 Dao-Fu Dai Chapter 13 The Role of Mitochondrial Dysfunction in Mitophagy and Apoptosis and Its Relevance to Cancer .......143 Jan Ježek Chapter 14 Mitochondrial Dysfunction Linking Obesity and Asthma .......................................................................151 Naveen K. Bhatraju and Anurag Agrawal Chapter 15 Mitochondrial Dysfunction and Hearing Loss.........................................................................................163 María de la Luz Arenas Sordo Chapter 16 Superoxide Dismutase, Mitochondrial Dysfunction, and Neurodegenerative Diseases ............................171 Jahaun Azadmanesh and Gloria E. O. Borgstahl Chapter 17 Role of Post-Translational Modifications of Mitochondrial Complex I in Mitochondrial Dysfunction and Human Brain Pathologies .................................................................................................................191 Vismaya, Yogachar Chithra, and Muchukunte Mukunda Srinivas Bharath Chapter 18 Heme Oxygenase-1 in Kidney Health and Disease: Perspective of Mitochondrial Homeostasis ..............205 Pu Duann, Elias A. Lianos, and Pei-Hui Lin Chapter 19 Mitochondrial Transplantation in Myocardial Ischemia and Reperfusion Injury ....................................217 David Blitzer, Borami Shin, Alvise Guariento, Pedro J. del Nido, and James D. McCully Chapter 20 Mitochondrial Dysfunction in Diabetes ...................................................................................................231 Eric L. Johnson Chapter 21 Clinical Manifestation of Mitochondrial Disorders in Childhood............................................................243 Martin Magner Chapter 22 Mitochondrial Dysfunction and Epilepsies ..............................................................................................265 Bindu Parayil Sankaran and Arun B. Taly Chapter 23 Mitochondrial Dysfunction and Allergic Disease.....................................................................................277 Kritika Khanna and Anurag Agrawal SECTION III Factors Affecting Mitochondrial Function Chapter 24 Role of Carnosic Acid in Protection of Brain Mitochondria ....................................................................293 Marcos Roberto de Oliveira Chapter 25 Mitochondrial Dysfunction and Its Impact on Oxidative Capacity of Muscle .........................................309 Teet Seene Chapter 26 The Effects of Resveratrol on the Brain Mitochondria.............................................................................319 Marcos Roberto de Oliveira Chapter 27 Pathophysiology and Biomarkers of Mitochondrial Dysfunction Induced by Heavy Exercise .................335 Sergej M. Ostojic Chapter 28 Mitochondrial Pathologies and Their Neuromuscular Manifestations .....................................................341 Carlos Ortez and Andrés Nascimento Chapter 29 Mitochondrial Stress and Cellular Senescence..........................................................................................361 Irene L. Tan and Michael C. Velarde Chapter 30 Role of Mitochondrial Dysfunction in Human Obesity ...........................................................................379 David Albuquerque, Sara Silva, Daniel Álvarez-Vaca, Célia Aveleira, and Clévio Nóbrega Chapter 31 Roles of Melatonin in Maintaining Mitochondrial Welfare: Focus on Renal Cells...................................389 Feres José Mocayar Marón, Emiliano Diez, Russel J. Reiter, and Walter Manucha Chapter 32 Mitochondrial Dysfunction Affecting the Peripheral Nervous System in Diabetic Neuropathy and Avenues for Therapy..........................................................................................................................399 Jennifer Jossart, Taylor N. Dennis, and J. Jefferson P. Perry Chapter 33 Mitochondrial Dysfunction and Oxidative Stress in the Pathogenesis of Metabolic Syndrome................409 Qiaozhu Su and Hao Wang SECTION IV Immunity and Toxicity Chapter 34 Regulation of Antiviral Immunity by Mitochondrial Dynamics ..............................................................425 Mohsin Khan, Hasan Imam, and Saiful Anam Mir Chapter 35 Mitochondrial Dysfunction, Immune Systems, Their Diseases, and Possible Treatments.........................443 Elise Jacquin, Eric Hervouet, and Michaël Boyer-Guittaut Chapter 36 Organophosphorus Compound-Induced Mitochondrial Disruption........................................................461 Alan J. Hargreaves Chapter 37 Mitochondrial Dysfunction in Friedreich Ataxia .....................................................................................471 Rosella Abeti, Annalisa Baccaro, and Paola Giunti Index............................................................................................................................................................................477