The Creative Destruction of Medicine Lib/E: How the Digital Revolution Will Create Better Health Care

Until very recently, if you were to ask most doctors, they would tell you there were only two kinds of medicine: the quack kind, and the evidence-based kind. The former is baseless, and the latter based on the best information human effort could buy, with carefully controlled double-blind trials, hundreds of patients, and clear indicators of success.Well, Eric Topol isn't most doctors, and he suggests you entertain the notion of a third kind of medicine, one that will make the evidence-based state-of-the-art stuff look scarcely better than an alchemist trying to animate a homunculus in a jar. It turns out plenty of new medicines--although tested with what seem like large trials--actually end up revealing most of their problems only once they get out in the real world, with millions of people with all kinds of conditions mixing them with everything in the pharmacopeia. The unexpected interactions of drugs, patients, and diseases can be devastating. And the clear indicators of success often turn out to be minimal, often as small as one fewer person dying out of a hundred (or even a thousand), and often at exorbitant cost. How can we avoid these dangerous interactions and side-effects? How can we predict which person out of a hundred will be helped by a new drug, and which fatally harmed? And how can we avoid having to need costly drugs in the first place?It sure isn't by doing another four hundred-person trial. As Topol argues in The Creative Destruction of Medicine, it's by bringing the era of big data to the clinic, laboratory, and hospital, with wearable sensors, smartphone apps, and whole-genome scans providing the raw materials for a revolution. Combining all the data those tools can provide will give us a complete and continuously updated picture of every patient, changing everything from the treatment of disease, to the prolonging of health, to the development of new treatments. As revolutionary as the past twenty years in personal technology and medicine have been--remember phones the sizes of bricks that only made calls, or when the most advanced "genotyping" we could do involved discerning blood types and Rh-factors?--Topol makes it clear that we haven't seen a thing yet. With an optimism matched only by a realism gained through twenty-five years in a tough job, Topol proves the ideal guide to the medicine of the future--medicine he himself is deeply involved in creating.

About the Author :
Dr. Eric Topol is the executive vice president and a professor of molecular medicine at Scripps Research, the largest nonprofit biomedical institute in the United States. He is also founder and director of the Scripps Research Translational Institute and a practicing cardiologist. He is one of the top ten most cited researchers in medicine, known for his groundbreaking studies on AI in medicine, genomics, and digitized clinical trials. He was named to the Time 100 Health list of the most influential people in health in 2024. He writes the Substack newsletter Ground Truths and is the author of The Creative Destruction of Medicine, The Patient Will See You Now, Deep Medicine, and Super Agers. Reader of over 400 audiobooks, Dick Hill has won three coveted Audie awards and been nominated numerous times. He is also the recipient of several AudioFile Earphones Awards. AudioFile includes Dick on their prestigious list of "Golden Voices." Reader of over 400 audiobooks, Dick Hill has won three coveted Audie awards and been nominated numerous times. He is also the recipient of several AudioFile Earphones Awards. AudioFile includes Dick on their prestigious list of "Golden Voices."

Review :
Topol weaves useful knowledge about how to evaluate the choices open to patients into this exciting account of the revolutionary changes we can expect.-- "Kirkus" "Eric Topol outlines the creative destruction of medicine that must be led by informed consumers." -- "Mehmet Oz, MD" "Topol weaves useful knowledge about how to evaluate the choices open to patients into this exciting account of the revolutionary changes we can expect." -- "Kirkus Reviews " "With his mature-sounding voice, Dick Hill creates an appealing performance that conveys wonder and curiosity about this cutting-edge summary of how digital technology will change healthcare." -- "AudioFile"