This book aims to provide a comprehensive and systematic understanding of research on extracellular vesicles (EVs). Extracellular vesicles, including exosomes and microvesicles, are nano-sized lipid bilayer encapsulated membranes carrying proteins, lipids, nucleic acids. They are shed by the majority of the cells into the extracellular milieu and present in many biological fluids (blood, urine, saliva, breast milk, cerebrospinal fluid, follicular fluid, semen, lung lavage, and tears). With numerous research publications in recent years, the study of EVs is the emerging field across plenty of disciplines. Many researches and efforts have shown their biogenesis, multiple roles in physiological and pathophysiological processes, and their potential roles as therapeutic agents. The book is organized by outstanding scientists in EV field from the Chinese Society for Extracellular Vesicle (CSEV). It covers the biological basic research of EVs, especially on technologies and methods, as well as the clinical application of EVs as biomarkers for disease diagnosis and therapy.
Table of Contents:
Section 1 EVs biology and function.- Classification and nomenclature of extracellular vesicles.- EVs biogenesis and function.- The mechanism of interaction between extracellular vesicles and target cells.- Biological functions of EVs in various systems.- The role and mechanism of EVs in the process of disease.- Section 2 Technologies and methods for EVs research.- Methods for EV isolation, purification and characterization.- Technologies for the analysis of EV omics.- Flow cytometry for single EV analysis.- Microfluidics-based technologies for EVs research.- Biosensing Technologies for EVs detection.- Technology for EVs surface functionalization.- Technologies for visualization and tracking of EVs.- Methods for EVs function research.- Chemical Biology Investigation of Extracellular Vesicles.- Section 3 EVs biomarker in diseases.- EV biomarker screening and clinical verification.- EVs biomarker for cancer.- EVs biomarker for disease diagnosis.- EVs biomarker for immune disorder.- EVs biomarker for neurological diseases.- EVs biomarker for infectious disease.- EVs biomarker for renal diseases.- EVs biomarker for thrombosis.- Section 4 EVs for disease therapy and prevention.- Stem cell-derived EVs for disease therapy.- EVs in cancer immunotherapy.- Platelet-derived EVs in disease therapy.- Plant-derived Extracellular Nanovesicles for Disease Therapy.- EVs engineering for therapy.- Other EVs for disease therapy.- EV-based clinical trial.- Section 5 Introduction to the guidelines and resources for EV research.- Introduction to the guidelines for EV research.- Introduction to online nucleic acid database for EV research.- Introduction of systems biology in EV.
About the Author :
Dr. Qian Wang, Zhujiang Hospital, Southern Medical University, China
Dr. Qian Wang is a professor at Southern Medical University (SMU), the Secretary of the Party Committee of Zhujiang Hospital. He is the Expert enjoying special government allowances from the State Council, Famous teacher of the National Ten Thousand People Program, Leading Medical Talents in Guangdong Province, Outstanding Educators in Guangdong Province and the Outstanding Leader of Chinese Hospital and National Excellent Dean. He has received the first prize of Guangdong Education and Teaching Achievement Award and the first prize of Guangdong Science and Technology Progress Award. He was elected to the Director of the Extracellular Vesicles Professional Committee of Chinese Research Hospital Association, Vice president of Chinese Research Hospital Association, the Director of Laboratory Medicine Branch, Guangdong Medical Association, etc. His research interests include the precise diagnosis of cardiovascular diseases, the basic and applied research of extracellular vesicles, the research of high-quality development management of hospitals, etc. He has trained more than 120 graduate students, published nearly 200 papers and edited 8 monographs. .
Dr. Lei Zheng, Nanfang Hospital, Southern Medical University, Guangzhou, China
Dr. Lei Zheng is a professor at Southern Medical University (SMU). He is serving as Dean of the Department of Laboratory Medicine at Nanfang Hospital, Southern Medical University. He received Bachelor's and Master's degrees from the First Military Medical University in 1997 and 2000, and a PhD degree from Southern Medical University in 2006. His scientific interests focus on interdisciplinary research in EV-based theranostics. He has published over 250 papers that have been cited over 9,000 times, with an h-index of 51. He served as the Executive Chair of the International Society for Extracellular Vesicles (ISEV) Education Committee and the Vice President of the Chinese Society for Extracellular Vesicles (CSEV). He received the National Science Fund for Distinguished Young Scholars and the Chinese Experimental Medicine Outstanding Youth Award in 2020.
