This book addresses the critical challenge in cancer treatment, focusing on the precise delivery of therapeutic agents to cancer cells while sparing healthy tissue. It emphasizes the limitations of current cancer therapies and highlights the potential of nanotechnology to revolutionize cancer treatment. It discusses how core-shell nano constructs, with their enhanced stability, biocompatibility, and targeting capabilities, emerge as a promising solution. The book covers the synthesis of novel core-shell nano constructs while elaborating on the chemistry involved in their fabrication. It explores various therapeutic and diagnostic applications of these nano constructs in cancer treatment, considering different materials such as polymers, lipids, and metals and the importance of diagnostics, biosensors, and targeting strategies to achieve site-specific delivery while minimizing toxicity to healthy cells.
Additionally, the book addresses regulatory and commercialization aspects,emphasizing the need for comprehensive characterization techniques to assess the effectiveness of core-shell nano constructs. This book is an invaluable resource for students, researchers, and professionals in the field.
Table of Contents:
1 Introduction and Basic considerations of core shell nanoconstructs
.- Chapter 1: Introduction to core shell nanoconstructs in cancer theragnostics.- Chapter 2: Physicochemical properties of core shell nanoconstructs.- Chapter 3: Surface chemistries and targeting strategies of core shell nanoconstructs in cancer theragnostics.- Chapter 4: Tumor microenvironment-responsive core shell nanoconstructs in cancer theragnostics .- Chapter 5: Core shell nanoconstructs for cancer-based biomedical applications.- Chapter 6: Core/multi-shell type of core shell nanoconstructs for cancer theragnostics.- Chapter 7: Core shell nanoconstructs in cancer biosensing: Techniques, Applications, and Fabrication Strategies.- Chapter 8: Characterization and Evaluation techniques for core shell nanoconstructs for cancer theragnostics
2 Organic/Organic Core Shell Nanoconstructs
.- Chapter 9: Polymer/polymer core shell nanoconstructs for cancer theragnostics .- Chapter 10:Polymer/Lipid core shell nanoconstructs for cancer theragnostics.- Chapter 11:Lipid/Polymer core shell nanoconstructs for cancer theragnostics
3 Inorganic/Organic Core shell Nanoconstructs
.- Chapter 12:Magnetic/Organic core shell nanoconstructs for cancer theragnostics .- Chapter 13:Non-magnetic/Organic core shell nanoconstructs for cancer theragnostics
4 Organic/Inorganic Core Shell Nanoconstructs
.- Chapter 14:Advances in Organic/Magnetic core shell nanoconstructs for cancer theragnostics.- Chapter 15:Innovative Organic/Non-magnetic core shell nanoconstructs: Pioneering Precision in Cancer Theragnostics
5 Inorganic/Inorganic Core Shell Nanoconstructs
.- Chapter 16:Silica/Non-silica-based core shell nanoconstructs for cancer theragnostics.- Chapter 17:Semiconductor/Non-semiconductor-based core shell nanoconstructs for cancer theragnostics.- Chapter 18:Lanthanide-based core shell nanoconstructs for cancer theragnostics.- Chapter 19: Upconversion core shell nanoconstructs for cancer theragnostics
6 Toxicological and Regulatory Aspects
.- Chapter 20: Toxicological aspects of core shell nanoconstructs .- Chapter 21: Clinical applications and Commercialization challenges of core shell nanoconstructs.
About the Author :
Dr. Jayvadan Patel
Dr. Jayvadan Patel is a formulation scientist at Aavis Pharmaceuticals, Hoschton, USA and professor emeritus, faculty of pharmacy, Sankalchand University, Gujarat, India. He has more than 26 years of research, academic, and industry experience. Dr. Jayvadan has published various research papers and co-authored a few books. Department of Science and Technology, Ministry of Science and Technology, Government of India has published International Comparative Research Base (2009-14) and Dr. Patel has been put in an honours list of 4th Rank of the Top 10 authors in the subject area Pharmacology, Toxicology, and Pharmaceutics. He is the recipient of the "AICTE-Visvesvaraya Best Teachers Award-2020" by the All India Council for Technical Education, Government of India, and the APTI-young Pharmacy Teacher Award (2014) by the Association of Pharmaceutical Teachers of India.
Dr. Namdev Dhas
Dr. Namdev Dhas is currently working as an assistant professor inthe department of pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education (MAHE), Karnataka, India. He received his PhD from the Institute of Pharmacy, Nirma University, Ahmedabad, Gujarat in 2021 and completed his M. Pharmacy in pharmaceutics from North Maharashtra University, Maharashtra. His area of research includes material science and engineering, multimodal therapeutic platforms, and inorganic nanocomposites for cancer therapy. The focus is to synthesize different metal-based nanoplatforms and how their properties will affect the efficiency of therapy and diagnosis. He has published a few research and review articles in international journals. He was recently awarded with an award entitled "Excellent Research in Pharmaceutical Science" by Indian Drug Manufacturing Association (IDMA) and Healthcopeia in july 2022. He also received the "Young Researcher Award 2020" organized by the Institute of Scholars.
Dr. Gaurav K. Saraogi
Dr. Gaurav K. Saraogi, currently working as professor and principal at Sri Aurobindo Institute of Pharmacy, Indore, Madhya Pradesh, India, did his Ph.D. in pharmaceutical sciences from the department of pharmaceutical sciences, Dr. H. S. Gour Central University Sagar, Madhya Pradesh, India in 2010. He has more than seventeen years of experience both in research and academia. His areas of research are nanotechnology and targeted tubercular therapy, dendrimers, transdermal and nasal delivery-based approaches for the effective delivery of drugs and other bio-actives. He has worked as an associate professor at the school of pharmacy and technology management, Shri Vile Parle Kelavani Mandal (SVKM) NMIMS University Shirpur, Maharashtra, India.
