Receptors in the Developing Nervous System: Volume 2 Neurotransmitters

Receptors for cell hormones, growth factors, Fourth, alterations in the development of neu­ and neurotransmitters are involved in the ral receptors may have profound implications control and modulation of an enormous array for the structure and function of the of biological processes. The development of organism. As much as possible, the reper­ these receptors has distinct spatial and tem­ cussions of disrupting the orchestration of poral arrangements, and alterations in this receptor development in the nervous system pattern during embryogenesis can have signi­ are discussed. In many instances, however, ficant consequences for the well-being of the we are just beginning to learn about some fetus, infant, child and adult. The developing receptors and the authors may not be in a nervous system is particularly dependent on position to discuss the consequences of recep­ receptors because its period of structural and tor dysfunction. functional organization extends through both In designing these two volumes, we have prenatal and postnatal phases. Moreover, asked major figures in each field to review the receptors are a key element in neural com­ literature, to apprise the audience of their munication in both the developing and adult latest findings, and to provide a perspective on organism, so that the ontogeny of receptors is the role of receptors in the developing nervous crucial in determining the myriad connections system. These books are intended to sum­ forming the circuitry of the nervous system.

Table of Contents:
1 Developmental expression of adrenergic receptors in the central nervous system.- 1.1 Introduction.- 1.2 Development of the norepinephrine neurotransmitter system in the nervous system.- 1.3 Development of ß1 and ß2 adrenergic receptors in the nervous system.- 1.4 Development of ?1AR in the nervous system.- 1.5 Development of ?2AR in the nervous system.- 1.6 Development of G proteins and effector systems in the nervous system.- 1.7 Adrenergic receptors and implications for development.- 1.8 Summary and future prospects.- References.- 2 Muscarinic receptors and the developing nervous system.- 2.1 Introduction.- 2.2 Muscarinic receptor subtypes.- 2.3 Second messenger systems.- 2.4 Regulation of muscarinic receptors.- 2.5 Muscarinic receptors in the developing nervous system.- 2.6 Possible role of muscarinic receptors in the development of the nervous system.- 2.7 Muscarinic receptors as targets for developmental neurotoxicity.- 2.8 Conclusions.- Acknowledgements.- References.- 3 The role of serotonin and serotonin receptors in development of the mammalian nervous system.- 3.1 Development of the serotonin neuronal system.- 3.2 Serotonin receptors involved in development.- 3.3 Conclusion.- Acknowledgements.- References.- 4 Neurokinin and substance P receptors in the developing rat central nervous system.- 4.1 Introduction.- 4.2 Biological functions of neurokinins.- 4.3 Ontogenic profile of NK receptor subtypes.- 4.4 Possible significance of ontogenic receptor modifications.- 4.5 Ontogenic profile of NK functions.- 4.6 Factors which can influence the development of SP and NK-1 receptors.- 4.7 Summary.- Acknowledgements.- References.- 5 Ontogeny of brain cholecystokinin receptors.- 5.1 Introduction.- 5.2 CCK receptor subtypes.- 5.3 Autoradiographic receptordistribution.- 5.4 Development of central CCK and its receptors.- 5.5 Development of CCK-containing neurons in the rat CNS.- 5.6 Other CCK receptor systems.- 5.7 Conclusions.- References.- 6 GABAA/benzodiazepine receptors in the developing mammalian brain.- 6.1 The GABAA benzodiazepine receptors.- 6.2 The GABAR/BZDR during mammalian brain development.- 6.3 The GABAR/BZDR and brain plasticity.- 6.4 Development of the GABAR/BZDR in neuronal cultures.- 6.5 Summary.- Acknowledgement.- References.- 7 GABA and benzodiazepine receptors in the developing visual system.- 7.1 Introduction.- 7.2 GABA and the visual system.- 7.3 GABA and visual deprivation.- 7.4 Summary and conclusions.- References.- 8 Receptors for glutamate and other excitatory amino acids: a cause for excitement in nervous system development.- 8.1 Introduction.- 8.2 Pharmacology.- 8.3 Molecular biology.- 8.4 Physiology.- 8.5 The role of EAA receptors during nervous system development.- 8.6 Summary.- Glutamate receptor update.- References.- 9 Neurotensin receptors during the development of the central nervous system.- 9.1 Neurotensin as a neurotransmitter.- 9.2 Neurotensin binding sites in the CNS: characterization and distribution.- 9.3 Characteristics of neurotensin receptor gene.- 9.4 Neurotensin receptors during the development of the CNS.- 9.5 Concluding remarks.- Acknowledgements.- References.- 10 Opioid receptors and the developing nervous system.- 10.1 Introduction.- 10.2 Endogenous opioid peptides.- 10.3 Opioid receptors.- 10.4 Developmental role.- Acknowledgements.- References.- 11 Sigma receptors, PCP receptors and the developing nervous system.- 11.1 Introduction.- 11.2 Identification and characterization of sigma and PCP receptors.- 11.3 Distribution of sigma and PCP receptors in the brain.- 11.4 Functional relevance of sigma and PCP receptors.- 11.5 Sigma and PCP receptors in the developing brain.- 11.6 Summary and conclusions.- References.- 12 Opioid receptors and peptide system regulation in the developing nervous system.- 12.1 Introduction.- 12.2 History of substance abuse.- 12.3 Effects of chronic administration in the adult CNS.- 12.4 Regulation of opioid receptors in neonatal rat brain.- 12.5 Cocaine and the opioid system.- Acknowledgement.- References.