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Home > Medicine & Health Science textbooks > Medicine: general issues > Regulacja fosfatazy cyklu komórkowego CDC25C w ostrej bialaczce
Regulacja fosfatazy cyklu komórkowego CDC25C w ostrej bialaczce

Regulacja fosfatazy cyklu komórkowego CDC25C w ostrej bialaczce


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About the Book

Wewnętrzne tandemowe duplikacje w genie receptora FLT3 (FLT3-ITD) występują u okolo 30% pacjentów z ostrą bialaczką szpikową (AML). Ten onkogen wplywa na różne funkcje komórek AML i prowadzi do niekontrolowanej proliferacji. Klinicznie, FLT3-ITD wiąże się ze zlym rokowaniem u pacjentów z AML. W niniejszym badaniu zbadano wplyw FLT3-ITD na fosfatazę CDC25C, która jako regulator cyklu komórkowego znacząco wplywa na kontrolę podzialu komórek. Opisane eksperymenty wykazaly, że CDC25C jest fosforylowana przez FLT3-ITD i aktywowana w niekontrolowany sposób. W modelu komórek bialaczkowych wykazano glównie ochronne dzialanie CDC25C w obecności stresu onkogennego. Genetycznie nieuszkodzone komórki byly w coraz większym stopniu powstrzymywane przed podzialem przez CDC25C. Jednak jednoczesna obecnośc mutacji FLT3-ITD spowodowala utratę tej funkcji ochronnej. Znaczenie opisanego tutaj mechanizmu polega zatem na kontroli odpowiedzi komórki bialaczkowej na uszkodzenia DNA. CDC25C nie pelni jednak funkcji onkogennej w klasycznym sensie.


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Product Details
  • ISBN-13: 9786208902766
  • Publisher: Wydawnictwo Nasza Wiedza
  • Publisher Imprint: Wydawnictwo Nasza Wiedza
  • Height: 229 mm
  • No of Pages: 68
  • Returnable: N
  • Weight: 154 gr
  • ISBN-10: 6208902762
  • Publisher Date: 29 May 2025
  • Binding: Paperback
  • Language: Polish
  • Returnable: N
  • Spine Width: 4 mm
  • Width: 152 mm


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Regulacja fosfatazy cyklu komórkowego CDC25C w ostrej bialaczce
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