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Composti naturali e nanoformulazioni per lesioni renali da cisplatino

Composti naturali e nanoformulazioni per lesioni renali da cisplatino


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About the Book

Il danno renale acuto indotto dal cisplatino rimane una sfida clinica importante a causa della sua patogenesi multifattoriale che coinvolge stress ossidativo, infiammazione, apoptosi e fibrosi. Un numero crescente di evidenze sostiene il potenziale nefroprotettivo di composti naturali come l'olio di germe di grano, la Moringa oleifera, il Ficus carica, il resveratrolo, gli acidi grassi polinsaturi omega-3 e la curcumina. Questi agenti presentano proprietà antiossidanti, antinfiammatorie, antiapoptotiche e antifibrotiche attraverso meccanismi che includono l'attivazione della via Nrf2, l'inibizione di NF-κB e delle citochine pro-infiammatorie e la conservazione dell'architettura renale. Una maggiore efficacia è stata ottenuta grazie a sistemi di somministrazione basati sulle nanotecnologie, come nanoemulsioni, nanoparticelle d'oro e vettori rivestiti di HA, che migliorano la biodisponibilità e il targeting renale. Nel complesso, questi composti naturali, in particolare in nanoforma, offrono un approccio terapeutico promettente, sicuro e multitarget per mitigare l'AKI indotta dal cisplatino senza compromettere i suoi effetti antitumorali, che meritano ulteriori indagini cliniche.


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Product Details
  • ISBN-13: 9786208884925
  • Publisher: Edizioni Sapienza
  • Publisher Imprint: Edizioni Sapienza
  • Height: 229 mm
  • No of Pages: 68
  • Returnable: N
  • Weight: 154 gr
  • ISBN-10: 6208884926
  • Publisher Date: 17 Sep 2025
  • Binding: Paperback
  • Language: Italian
  • Returnable: N
  • Spine Width: 4 mm
  • Width: 152 mm


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