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Polymorphisme dans le promoteur du gène mif et risque de cancer de la vessie

Polymorphisme dans le promoteur du gène mif et risque de cancer de la vessie


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About the Book

L'objectif de ce chapitre est de présenter les dernières recherches fondamentales sur le rôle du polymorphisme dans le promoteur du facteur inhibiteur de la migration des macrophages (MIF) et le risque de cancer de la vessie. Le gène MIF se trouve sur le chromosome 22q11.2 et sa régulation est contrôlée par deux sites polymorphes dans la région du promoteur. Le premier site consiste en une répétition CATT à -794 qui se répète 5 à 8 fois et le second site est un polymorphisme d'un seul nucléotide à -173(G/C) qui est associé à une activité accrue du promoteur dans certaines lignées cellulaires cancéreuses et l'activité est proportionnelle à l'augmentation des niveaux de MIF dans le sérum. Le MIF renforce la transcription, l'activation et la viabilité des macrophages, associé à ses effets inhibiteurs sur les lymphocytes cytotoxiques des cellules antitumorales, ce qui suggère que la surexpression du MIF dans les tumeurs malignes en développement peut agir de concert pour faciliter une croissance tumorale accrue, ce qui présente un lien important entre l'inflammation et le cancer en raison de son rôle pro-inflammatoire. Le MIF se lie au domaine extracellulaire du CD74 avec une grande affinité et initie une cascade de signalisation.


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Product Details
  • ISBN-13: 9786208520915
  • Publisher: Editions Notre Savoir
  • Publisher Imprint: Editions Notre Savoir
  • Height: 229 mm
  • No of Pages: 72
  • Returnable: N
  • Weight: 168 gr
  • ISBN-10: 6208520916
  • Publisher Date: 31 Dec 2024
  • Binding: Paperback
  • Language: French
  • Returnable: N
  • Spine Width: 4 mm
  • Width: 152 mm


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