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Home > Medicine & Health Science textbooks > Medicine: general issues > Factores de risco do carcinoma hepatocelular
Factores de risco do carcinoma hepatocelular

Factores de risco do carcinoma hepatocelular


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About the Book

O carcinoma hepatocelular é multifatorial em termos de etiologia e complexo em termos de patogénese. A combinação de factores de risco difere em diferentes partes do mundo, o que pode explicar em parte as diversas caraterísticas biológicas do CHC em diferentes populações. O CHC é único na medida em que ocorre em grande parte num contexto estabelecido de doença hepática crónica e cirrose (70-90% de todos os casos detectados de CHC). O sexo masculino, a idade e a duração da cirrose são os principais factores de risco para o carcinoma hepatocelular em doentes cirróticos. A tendência crescente do CHC tem sido associada ao aumento da prevalência da infeção pelo vírus da hepatite C (VHC). O VHC é considerado um dos principais factores de risco para a progressão para cirrose hepática e CHC. A integração do ADN viral no genoma do hospedeiro foi sugerida como sendo o evento inicial da carcinogénese induzida pelo VHB. Alguns dados sugerem que a proteína HBx pode inativar o p53 (gene supressor de tumores), levando ao desenvolvimento de CHC. As aflatoxinas são micotoxinas que ocorrem naturalmente e que se encontram em diferentes alimentos, tendo sido demonstrado que são carcinogénicas.


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Product Details
  • ISBN-13: 9786208318796
  • Publisher: Edicoes Nosso Conhecimento
  • Publisher Imprint: Edicoes Nosso Conhecimento
  • Height: 229 mm
  • No of Pages: 88
  • Returnable: N
  • Weight: 190 gr
  • ISBN-10: 6208318793
  • Publisher Date: 22 Nov 2024
  • Binding: Paperback
  • Language: Portuguese
  • Returnable: N
  • Spine Width: 5 mm
  • Width: 152 mm


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