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Concepts récents en thérapie de modulation de l'hôte

Concepts récents en thérapie de modulation de l'hôte


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About the Book

Les maladies parodontales sont provoquées par des biofilms microbiens Gram-négatifs associés aux dents qui déclenchent une réponse de l'hôte, entraînant la destruction des tissus osseux et mous. En réponse aux endotoxines dérivées des agents pathogènes parodontaux, plusieurs médiateurs liés aux ostéoclastes ciblent la destruction de l'os alvéolaire et des tissus conjonctifs de soutien. Les principaux responsables de cette destruction agressive des tissus sont les métalloprotéinases matricielles (MMP), les cathepsines, les cytokines et d'autres enzymes dérivées des ostéoclastes. Cet ouvrage se concentre sur les facteurs en aval de l'ostéoclaste responsables de la dégradation de l'os et des tissus mous autour des dents. En outre, diverses approches thérapeutiques ciblant les MMP, les cytokines, les cathepsines et d'autres enzymes dérivées des ostéoclastes, telles que les inhibiteurs de MMP, les tétracyclines chimiquement modifiées, les formulations subantimicrobiennes d'analogues de la tétracycline et divers nouveaux agents tels que les vaccins parodontaux, les probiotiques, les proanthocyanidines de pépins de raisin, la fraction de canneberge, les acides gras oméga 3, les agents HMT administrés localement sont discutées. En outre, des études utilisant d'autres agents pour la préservation de la masse osseuse, tels que les bisphosphonates qui inhibent le recrutement des ostéoclastes, sont mises en évidence.


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Product Details
  • ISBN-13: 9786202736855
  • Publisher: Editions Notre Savoir
  • Publisher Imprint: Editions Notre Savoir
  • Height: 229 mm
  • No of Pages: 144
  • Returnable: N
  • Weight: 254 gr
  • ISBN-10: 6202736852
  • Publisher Date: 05 Mar 2025
  • Binding: Paperback
  • Language: French
  • Returnable: N
  • Spine Width: 9 mm
  • Width: 152 mm


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