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Administration simultanée d'inhibiteurs du CYP dans le cas d'une LAM

Administration simultanée d'inhibiteurs du CYP dans le cas d'une LAM


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About the Book

Étude rétrospective cas-témoins menée auprès de n = 108 patients préalablement sélectionnés, atteints d'une LAM et hospitalisés dans un établissement allemand. Une application simultanée d'inhibiteurs du CYP a été constatée chez 59 des 108 patients atteints de LAM (54,6 %). Les 59 patients atteints de LAM ont subi significativement plus (p = 0,036) d'effets indésirables (1489 sur 2483, soit 59,9 %) que les patients atteints de LAM sans administration simultanée d'inhibiteurs du CYP (994 sur 2483, soit 40,1 %). Au moins une interaction potentielle avec un inhibiteur du CYP a été constatée chez 59 des 59 patients atteints de LAM qui ont reçu simultanément un inhibiteur du CYP. Les femmes présentent significativement plus d'interactions potentielles avec un inhibiteur du CYP par jour (0,321) et par séjour hospitalier que les hommes (p = 0,038). 721 des 1489 événements indésirables (48,4 %) survenus chez les n = 59 patients atteints de LAM correspondaient aux effets indésirables des inhibiteurs du CYP administrés simultanément et ont été considérés comme une interaction potentielle avec un inhibiteur du CYP. Sur n = 108, environ un patient LAM sur deux a reçu simultanément un inhibiteur du CYP et a présenté au moins une interaction potentielle avec un inhibiteur du CYP, en particulier les femmes.


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Product Details
  • ISBN-13: 9786202371384
  • Publisher: Editions Notre Savoir
  • Publisher Imprint: Editions Notre Savoir
  • Height: 229 mm
  • No of Pages: 120
  • Returnable: N
  • Weight: 222 gr
  • ISBN-10: 6202371382
  • Publisher Date: 11 Aug 2025
  • Binding: Paperback
  • Language: French
  • Returnable: N
  • Spine Width: 7 mm
  • Width: 152 mm


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