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Convolução, efeito das bebidas alcoólicas nas cápsulas de lansoprazol DR

Convolução, efeito das bebidas alcoólicas nas cápsulas de lansoprazol DR


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About the Book

O efeito potencial das bebidas alcoólicas na alteração da libertação de medicamentos de uma forma farmacêutica oral é uma preocupação geral. O lansoprazol, um inibidor da bomba de protões, é utilizado no tratamento de úlceras no estômago e no duodeno. A fim de proteger este medicamento instável ao ácido da degradação no meio gástrico, as formas farmacêuticas orais comercializadas são formuladas em cápsulas contendo pellets de libertação retardada e comprimidos orais de libertação retardada que se desintegram na boca. Os objetivos deste capítulo eram principalmente quatro. O primeiro era compreender como a forma farmacêutica foi formulada. O segundo era combinar os dados coletados em um estudo de dissolução in vitro com o perfil temporal da concentração plasmática de lansoprazol em bolus intravenoso relatado por Gerloff et al. para investigar o principal local de liberação do fármaco e a taxa de absorção. O terceiro era propor preparações laboratoriais de bebidas alcoólicas para simular a administração deste medicamento com um copo de cerveja ou vinho. O quarto era usar os dados de dissolução in vitro do objetivo n° 3 para determinar se o fator de similaridade da FDA para cápsulas de libertação retardada deveria ser plotado a partir (a) dos estágios ácido a tampão, ou (2) apenas do estágio tampão.


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Product Details
  • ISBN-13: 9786200826091
  • Publisher: Edicoes Nosso Conhecimento
  • Publisher Imprint: Edicoes Nosso Conhecimento
  • Height: 229 mm
  • No of Pages: 52
  • Returnable: N
  • Weight: 136 gr
  • ISBN-10: 6200826099
  • Publisher Date: 27 Jul 2025
  • Binding: Paperback
  • Language: Portuguese
  • Returnable: N
  • Spine Width: 3 mm
  • Width: 152 mm


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Convolução, efeito das bebidas alcoólicas nas cápsulas de lansoprazol DR
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