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Flap Structure-Specific Endonuclease 1

Flap Structure-Specific Endonuclease 1


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About the Book

Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. Flap endonuclease 1 is an enzyme that in humans is encoded by the FEN1 gene.The protein encoded by this gene removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate, thus passing the substrate from one enzyme to another. The protein is a member of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication. DNA secondary structure can inhibit flap processing at certain trinucleotide repeats in a length-dependent manner by concealing the 5' end of the flap that is necessary for both binding and cleavage by the protein encoded by this gene.


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Product Details
  • ISBN-13: 9786136432724
  • Publisher: Betascript Publishing
  • Publisher Imprint: Betascript Publishing
  • Height: 229 mm
  • Weight: 136 gr
  • ISBN-10: 6136432722
  • Publisher Date: 18 Jul 2011
  • Binding: Paperback
  • Spine Width: 5 mm
  • Width: 152 mm


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