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The Genetics of Complex Thyroid Diseases

The Genetics of Complex Thyroid Diseases


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About the Book

The autoimmune thyroid diseases and familial thyroid cancers are the current target of molecular thyroid genetics. Unlike the situation in monogenic thyroid diseases, for which the molecular genetics has largely been clarified over the past 20 years, a methodological approach to these more complex forms of thyroid disease has not yet been well established. The determination of susceptibility genes, for example, remains a major challenge. The contributors to this volume are attempting to meet that challenge in research on molecular genetics. Meeting at the first International Symposium on the Genetics of Complex Thyroid Diseases, held in Kyoto, Japan, 20 distinguished researchers from five countries in addition to Japan shared their latest results and engaged in intense discussion, focusing on the autoimmune thyroid diseases and familial thyroid cancers. Their papers collected here are a valuable contribution to the field of the genetics of complex thyroid diseases.

Table of Contents:
1 Autoimmune Thyroid Diseases.- Genetic dissection of familial autoimmune thyroid diseases using whole genome screening.- Genome screening for Graves’ disease susceptibility loci in U.K. families.- The involvement of the HLA region in genetic susceptibility to Grave s’ disease.- HLA and autoimmune thyroid diseases.- What can we learn from the genetics of diabetes?.- The genomic biology of the human chromosome 2q33 costimulatory receptor region.- CTLA-4 gene in the pathogenesis of Graves’ disease.- The evolving role of CTLA-4 in the genetic predisposition to AITD.- Association of AITD with microsatellite markers for TSHR and CTLA-4 in Japanese patients.- 2 Familial Thyroid Cancers.- Familial non medullary thyroid cancer.- Cowden disease and the PTEN/MMACI gene.- Molecular mechanisms of RET activation in human neoplasia.- Lessons from Chernobyl; need for molecular epidemiology of childhood thyroid cancer.- Genetic events in radiation-induced thyroid cancer.- Keyword Index.


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Product Details
  • ISBN-13: 9784431703259
  • Publisher: Springer Verlag, Japan
  • Publisher Imprint: Springer Verlag, Japan
  • Height: 235 mm
  • No of Pages: 222
  • Returnable: Y
  • ISBN-10: 443170325X
  • Publisher Date: 01 Jan 2002
  • Binding: Hardback
  • Language: English
  • Returnable: Y
  • Width: 155 mm


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