About the Book
This special issue of Acta Cytologica focuses on new insights into thyroid fine needle aspiration (FNA). With the adoption of The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC), the terminology obstacle has been overcome, but challenges remain, not the least of which is the application of the new terminology in practice. This issue points the way forward. TBSRTC is reviewed, with salient observations on the distinctions between categories. Data are presented on the histologic outcomes associated with the categories used in the United Kingdom, which allow for concordance with TBSRTC. A European consortium discusses the merits of implementing TBSRTC in the European community. Several papers dig deeply into the AUS/FLUS category, examining the variables that influence its rate and associated histologic outcome. Another study examines the common approach of waiting a few months before repeating an aspirate in patients whose prior thyroid FNA was inconclusive. New data is presented on the management of the patient with a repeatedly nondiagnostic thyroid FNA. This issue also includes descriptions of the mucin-producing tumors of the thyroid and papillary thyroid carcinomas that arise within a follicular adenoma. Several studies delve into the unfolding interface between cytology and molecular diagnostics. Finally, investigators examine high-resolution magic angle spinning proton magnetic resonance spectroscopy as an adjunct to cytology. As a group, these papers provide a snapshot of the state of the art as well as a glimpse into the future of thyroid FNA.
Table of Contents:
Editorial; Thyroid FNA: Challenges and Opportunities: Cibas, E.S.; Bibbo, M.; Variability in the Atypia of Undetermined Significance/Follicular Lesion of Undetermined Significance Diagnosis in the Bethesda System for Reporting Thyroid Cytopathology: Sources and Recommendations: Ohori, N.P.; Schoedel, K.E.; The UK Royal College of Pathologists Thyroid Fine-Needle Aspiration Diagnostic Classification Is a Robust Tool for the Clinical Management of Abnormal Thyroid Nodules: Lobo, C.; McQueen, A.; Beale, T.; Kocjan, G.; The Bethesda Terminology for Reporting Thyroid Cytopathology: From Theory to Practice in Europe: Cochand-Priollet, B.; Schmitt, F.C.; Totsch, M.; Vielh, P.; European Federation of Cytology Societies' Scientific Committee; The Frequency of 'Atypia of Undetermined Significance' Interpretations for Thyroid Fine-Needle Aspirations Is Negatively Correlated with Histologically Proven Malignant Out-comes: VanderLaan, P.A.; Krane, J.F.; Cibas, E.S.; Spectrum of Risk of Malignancy in Subcategories of 'Atypia of Undetermined Significance': Olson, M.T.; Clark, D.P.; Erozan, Y.S.; Ali, S.Z.; Atypical Follicular Cells with Equivocal Features of Papillary Thyroid Carcinoma Is Not a Low-Risk Cytologic Diagnosis: Luu, M.H.; Fischer, A.H.; Stockl, T.J.; Pisharodi, L.; Owens, C.L.; Cytologic Features of Focal Papillary Thyroid Carcinoma Arising within Follicular Adenoma: A Masked Cytomorphologic Analysis of 17 Cases: Ono, J.C.; Wilbur, D.C.; Lee, H.; Yang, J.; Krane, J.F.; Bongiovanni, M.; Faquin, W.C.; Repeatedly Nondiagnostic Thyroid Fine-Needle Aspirations Do Not Modify Malignancy Risk: Jo, V.Y.; VanderLaan, P.A.; Marqusee, E.; Krane, J.F.; Timing of Repeat Thyroid Fine-Needle Aspiration in the Management of Thyroid Nodules: Singh, R.S.; Wang, H.H.; Fine-Needle Aspiration of Mucin-Producing Thyroid Tumors: Yang, G.C.H.; Scognamiglio, T.; Kuhel, W.I.; The Relationship of Cytomorphology of Medullary Thyroid Carcinomas between Family Members with the Same RET Proto-Oncogene Mutation: Chang, J.-S.; Chang, C.-F.; Yang, W.-S.; Chang, T.-C.; BRAF Mutation Analysis of Fine-Needle Aspiration Biopsies of Papillary Thyroid Carcinoma: Impact on Diagnosis and Prognosis: Colanta, A.; Lin, O.; Tafe, L.; Ghossein, R.; Nafa, K.; Mitchell, T.; Ladanyi, M.; Arcila, M.; BRAF Mutation Testing of Thyroid Fine-Needle Aspiration Specimens Enhances the Predictability of Malignancy in Thyroid Follicular Lesions of Undetermined Significance: Adeniran, A.J.; Hui, P.; Chhieng, D.C.; Prasad, M.L.; Schofield, K.; Theoharis, C.; Allele-Specific PCR with Competitive Probe Blocking for Sensitive and Specific Detection of BRAF V600E in Thyroid Fine-Needle Aspiration Specimens: Smith, G.D.; Zhou, L.; Rowe, L.R.; Jarboe, E.A.; Collins, B.T.; Bentz, J.S.; Wittwer, C.T.; Chadwick, B.E.; Application of Magnetic-Resonance-Spectroscopy-Based Metabolomics to the Fine-Needle Aspiration Diagnosis of Papillary Thyroid Carcinoma: Jordan, K.W.; Adkins, C.B.; Cheng, L.L.; Faquin, W.C.; Author Index Vol 55, No. 6, 2011; Subject Index Vol 55, No. 6, 2011; Acknowledgement to Reviewers; Author Index Vol 55, 2011; Subject Index Vol 55, 2011.
